Robert van Oostenbrugge

Professor

Robert van Oostenbrugge is Professor of Neurology, with a chair on Vascular Neurology, head of the Department of Neurology (UM); principal Investigator of CARIM and programme leader of Vascular Neurology / Stroke. Robert (R.J.) van Oostenbrugge; (born Havelte, 1965) obtained a MD at the Maastricht University in Maastricht (1990). He was registered as neurologist in 2000 and obtained a PhD in 1999 (University Maastricht, Maastricht). In 2013, he was appointed Professor of Neurology chair of the Department of Neurology at Maastricht University. He is member of the Centers of Excellence in Neurodegeneration initiative and of the JPND funded initiative HARNESS aiming to harmonise imaging standards in vascular dementia, member of the board of the Dutch Section of Vascular Neurology.

Department of Neurology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31 (0)43 387 70 58

 

  • 2012
    • Postma, A. A., Hofman, P. A. M., Stadler, A. A. R., van Oostenbrugge, R. J., Tijssen, M. P. M., & Wildberger, J. E. (2012). Dual-Energy CT of the Brain and Intracranial Vessels. American Journal of Roentgenology, 199(5), S26-S33. https://doi.org/10.2214/AJR.12.9115
    • Loos, C. M. J., Staals, J., Wardlaw, J. M., & van Oostenbrugge, R. J. (2012). Cavitation of Deep Lacunar Infarcts in Patients With First-Ever Lacunar Stroke A 2-Year Follow-Up Study With MR. Stroke, 43(8), 2245-U450. https://doi.org/10.1161/STROKEAHA.112.660076
    • Rouhl, R. P. W., Damoiseaux, J. G. M. C., Lodder, J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Tervaert, J. W. C., & van Oostenbrugge, R. J. (2012). Vascular inflammation in cerebral small vessel disease. Neurobiology of Aging, 33(8), 1800-1806. https://doi.org/10.1016/j.neurobiolaging.2011.04.008
    • Mees, S. M. D., Algra, A., Vandertop, W. P., van Kooten, F., Kuijsten, H. A. J. M., Boiten, J., van Oostenbrugge, R. J., Salman, R. A.-S., Lavados, P. M., Rinkel, G. J. E., & van den Bergh, W. M. (2012). Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet, 380(9836), 44-49. https://doi.org/10.1016/S0140-6736(12)60724-7
    • Dirks, M., Niessen, L. W., van Wijngaarden, J., Koudstaal, P. J., Franke, C. L., van Oostenbrugge, R. J., & Dippel, D. W. J. (2012). The effectiveness of thrombolysis with intravenous alteplase for acute ischemic stroke in daily practice. International journal of stroke, 7(4), 289-292. https://doi.org/10.1111/j.1747-4949.2011.00709.x
    • Knottnerus, I. L. H., Winckers, K., ten Cate, H., Hackeng, T. M., Lodder, J., Rouhl, R. P. W., Staals, J., Govers-Riemslag, J. W. P., Bekers, O., & van Oostenbrugge, R. J. (2012). Levels of heparin-releasable TFPI are increased in first-ever lacunar stroke patients. Neurology, 78(7), 493-498. https://doi.org/10.1212/WNL.0b013e318246d6b7
    • Huijts, M., Duits, A., Staals, J., & van Oostenbrugge, R. J. (2012). Association of Vitamin B12 Deficiency with Fatigue and Depression after Lacunar Stroke. PLOS ONE, 7(1), Article e30519. https://doi.org/10.1371/journal.pone.0030519
    • Rouhl, R. P. W., Mertens, A. E. C. S., van Oostenbrugge, R. J., Damoiseaux, J. G. M. C., Debrus-Palmans, L. L., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Lodder, J., & Tervaert, J. W. C. (2012). Angiogenic T-Cells and Putative Endothelial Progenitor Cells in Hypertension-Related Cerebral Small Vessel Disease. Stroke, 43(1), 256-U509. https://doi.org/10.1161/STROKEAHA.111.632208
    • Loos, C. M. J., van Oostenbrugge, R. J., & Staals, J. (2012). The Appearance of a New White Matter Lesion Adjacent to the Old Infarct in First-Ever Lacunar Stroke Patients: A Two-Year Follow-Up Study with MRI. Cerebrovascular Diseases, 34(5-6), 443-445. https://doi.org/10.1159/000344003
  • 2011
    • Hoff, E. I., Steinbusch, H. W. M., van Oostenbrugge, R. J., Garrett, L., Otte, W. M., van der Marel, K., & Dijkhuizen, R. M. (2011). Alterations in the cholinergic system after frontal cortical infarction in rat brain: Pharmacological magnetic resonance imaging of muscarinic receptor responsiveness and stereological analysis of cholinergic forebrain neurons. Neurobiology of Disease, 43(3), 625-634. https://doi.org/10.1016/j.nbd.2011.05.011
    • Kwee, R. M., Truijman, M. T. B., Mess, W. H., Teule, G. J. J., Ter Berg, J. W., Franke, CL., Korten, A. G., Meems, B. J., Prins, M. H., van Engelshoven, J. M. A., Wildberger, J. E., van Oostenbrugge, R. J., & Kooi, M. E. (2011). Potential of integrated (18F) fluordeoxyglucose positron-emission tomography/CT in identifying vulnerable carotid plaques. American Journal of Neuroradiology, 32(5), 950-954. https://doi.org/10.3174/ajnr.A2381
    • Dirks, M., Niessen, L. W., van Wijngaarden, J. D. H., Koudstaal, P. J., Franke, C. L., van Oostenbrugge, R. J., Huijsman, R., Lingsma, H. F., Minkman, M. M. N., & Dippel, D. W. J. (2011). Promoting Thrombolysis in Acute Ischemic Stroke. Stroke, 42(5), 1325-1330. https://doi.org/10.1161/STROKEAHA.110.596940
    • Klompenhouwer, E. G., Dings, J. T. A., van Oostenbrugge, R. J., Oei, S., Wilmink, J. T., & van Zwam, W. H. (2011). Single-Center Experience of Surgical and Endovascular Treatment of Ruptured Intracranial Aneurysms. American Journal of Neuroradiology, 32(3), 570-575. https://doi.org/10.3174/ajnr.A2326
    • Kwee, R. M., Hofman, P. A., Gronenschild, E. H., van Oostenbrugge, R. J., Mess, W. H., Ter Berg, J. W., Franke, CL., Korten, A. G., Meems, B. J., van Engelshoven, J. M., Wildberger, J. E., & Kooi, M. E. (2011). Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLOS ONE, 6(2), Article e17070. https://doi.org/10.1371/journal.pone.0017070
    • Henskens, L. H. G., van Boxtel, M. P. J., Kroon, A. A., van Oostenbrugge, R. J., Lodder, J., & de Leeuw, P. W. (2011). Sleep disturbance increases the nocturnal blood pressure level and attenuates the correlation with target organ damage. Journal of Hypertension, 29(2), 242-250. https://doi.org/10.1097/HJH.0b013e32834192d5
  • 2010
    • Rouhl, R. P. W., van Oostenbrugge, R. J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Lodder, J., Tervaert, J. W. C., & Damoiseaux, J. G. M. C. (2010). Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease. Stroke, 41(11), 2687-2689. https://doi.org/10.1161/STROKEAHA.110.592725
    • Knottnerus, I. L. H., Govers-Riemslag, J. W. P., Hamulyak, K., Rouhl, R. P. W., Staals, J., Spronk, H. M. H., van Oerle, R., van Raak, E. P. M., Lodder, J., ten Cate, H., & van Oostenbrugge, R. J. (2010). Endothelial Activation in Lacunar Stroke Subtypes. Stroke, 41(8), 1617-1622. https://doi.org/10.1161/STROKEAHA.109.576223
    • Hoff, E. I., van Oostenbrugge, R. J., Otte, W. M., van der Marel, K., Steinbusch, H. W. M., & Dijkhuizen, R. M. (2010). Pharmacological magnetic resonance imaging of muscarinic acetylcholine receptor activation in rat brain. Neuropharmacology, 58(8), 1252-1257. https://doi.org/10.1016/j.neuropharm.2010.03.007
    • Pisters, R., van Oostenbrugge, R. J., Knottnerus, I. L. H., De Vos, C. B., Boreas, A., Lodder, J., Prins, M. H., Crijns, H. J. G. M., & Tieleman, R. G. (2010). The likelihood of decreasing strokes in atrial fibrillation patients by strict application of guidelines. EP Europace, 12(6), 779-784. https://doi.org/10.1093/europace/euq080
    • Staals, J., Henskens, L. H. G., Delanghe, J. R., van Oostenbrugge, R. J., Kessels, A. G., Kroon, A. A., de Leeuw, P. W., & Lodder, J. (2010). Haptoglobin Phenotype Correlates with the Extent of Cerebral Deep White Matter Lesions in Hypertensive Patients. Current Neurovascular Research, 7(1), 1-5. https://doi.org/10.2174/156720210790820163
    • Kwee, R. M., van Oostenbrugge, R. J., Mess, W. H., Prins, M. H., van der Geest, R. J., Ter Berg, J. W., Franke, CL., Korten, A. G., Meems, B. J., van Engelshoven, J. M., Wildberger, J. E., & Kooi, M. E. (2010). Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.Investigative Radiology, 45(12), 803-809. https://doi.org/10.1097/RLI.0b013e3181ed15ff
    • Duits, A. A., Oirschot, N., van Oostenbrugge, R. J., & van Lankveld, J. J. D. M. (2010). Seksueel functioneren na een beroerte: de schaamte voorbij!Tijdschrift voor neuropsychologie, 5, 2-10.
    • van Overbeek, E. C., Knottnerus, I. L. H., & van Oostenbrugge, R. J. (2010). Disappearing Hyperdense Middle Cerebral Artery Sign Is Associated with Striatocapsular Infarcts on Follow-Up CT in Ischemic Stroke Patients Treated with Intravenous Thrombolysis. Cerebrovascular Diseases, 30(3), 285-289. https://doi.org/10.1159/000319071
    • Zhang, C. E., van Raak, E. P. M., Rouhl, R. P. W., Lodder, J., Staals, J., Knottnerus, I. L. H., & van Oostenbrugge, R. J. (2010). Metabolic Syndrome Relates to Lacunar Stroke without White Matter Lesions: A Study in First-Ever Lacunar Stroke Patients. Cerebrovascular Diseases, 29(5), 503-507. https://doi.org/10.1159/000297967
  • 2009
    • Duits, A., van Lankveld, J. J. D. M., van Oostenbrugge, R. J., & Oirschot, N. (2009). The relevance of sexual responsiveness to sexual function in male stroke patients. Journal of sexual medicine, 6, 3320-3326. https://doi.org/10.1111/j.1743-6109.2009.01419.x
  • 2008
    • Staals, J., Bons, J., van Oostenbrugge, R. J., Knottnerus, I. L., van Dieijen-Visser, M. P., Bouwman, F. G., Mariman, E. C., Delanghe, J. R., Lodder, J., & Wodzig, W. K. (2008). A SELDI-TOF-MS Study in Lacunar Stroke with Subsequent Haptoglobin Phenotyping. Current Neurovascular Research, 5(2), 93-98. https://doi.org/10.2174/156720208784310187
  • 2007
    • Hoff, E. I., van Oostenbrugge, R. J., Liedenbaum, M., Steinbusch, H. P. J., & Blokland, A. (2007). Effects of right-hemisphere cortical infarction and muscarinic acetylcholine receptor blockade on spatial visual attention performance in rats. Behavioural Brain Research, 178(1), 62-69. https://doi.org/10.1016/j.bbr.2006.12.001
  • 2006
    • Hoff, E. I., Blokland, A., Rutten, K., Steinbusch, H. W., & van Oostenbrugge, R. J. (2006). Dissociable effects in reaction time performance after unilateral cerebral infarction: a comparison between the left and right frontal cortices in rats. Brain Research, 1069(1), 182-189. https://doi.org/10.1016/j.brainres.2005.11.070
  • 2000
    • van Oostenbrugge, R. J., Hopman, A. H. N., Arends, J. W., Ramaekers, F. C. S., & Twijnstra, A. (2000). Treatment of leptomeningeal metastases evaluated by interphase cytogenetics.Journal of Clinical Oncology, 18, 2053-8. https://doi.org/10.1200/JCO.2000.18.10.2053