Robert van Oostenbrugge

Professor

Robert van Oostenbrugge is Professor of Neurology, with a chair on Vascular Neurology, head of the Department of Neurology (UM); principal Investigator of CARIM and programme leader of Vascular Neurology / Stroke. Robert (R.J.) van Oostenbrugge; (born Havelte, 1965) obtained a MD at the Maastricht University in Maastricht (1990). He was registered as neurologist in 2000 and obtained a PhD in 1999 (University Maastricht, Maastricht). In 2013, he was appointed Professor of Neurology chair of the Department of Neurology at Maastricht University. He is member of the Centers of Excellence in Neurodegeneration initiative and of the JPND funded initiative HARNESS aiming to harmonise imaging standards in vascular dementia, member of the board of the Dutch Section of Vascular Neurology.

Department of Neurology
P. Debyelaan 25, 6229 HX Maastricht
PO Box 5800, 6202 AZ Maastricht
T: +31 (0)43 387 70 58

2022
- Amini, M., van Leeuwen, N., Eijkenaar, F., van de Graaf, R., Samuels, N., van Oostenbrugge, R., van den Wijngaard, I. R., van Doormaal, P. J., Roos, Y. B. W. E. M., Majoie, C., Roozenbeek, B., Dippel, D., Burke, J., Lingsma, H. F., & MR CLEAN Registry Investigators (2022). Estimation of treatment effects in observational stroke care data: comparison of statistical approaches. BMC Medical Research Methodology, 22(1), Article 103. https://doi.org/10.1186/s12874-022-01590-0
- van der Steen, W., van de Graaf, R. A., Chalos, V., Lingsma, H. F., van Doormaal, P. J., Coutinho, J. M., Emmer, B. J., de Ridder, I., van Zwam, W., van der Worp, H. B., van der Schaaf, I., Gons, R. A. R., Yo, L. S. F., Boiten, J., van den Wijngaard, I., Hofmeijer, J., Martens, J., Schonewille, W., Vos, J. A., ... MR CLEAN-MED investigators (2022). Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial. Lancet, 399(10329), 1059-1069. https://doi.org/10.1016/S0140-6736(22)00014-9
- Peeters, M. T. J., Vroman, F., Schreuder, TAHCML., van Oostenbrugge, R. J., & Staals, J. (2022). Decrease in incidence of oral anticoagulant-related intracerebral hemorrhage over the past decade in the Netherlands. European Stroke Journal, 7(1), 20-27. Article 23969873211062011. https://doi.org/10.1177/23969873211062011
- Bernsen, M. L. E., Bruggeman, A. A. E., Brouwer, J., Emmer, B. J., Majoie, C. B. L. M., Coutinho, J. M., Goldhoorn, R.-J. B., van Oostenbrugge, R. J., van Zwam, W. H., van der Leij, C., Schonewille, W. J., Martens, J. M., Hofmeijer, J., & MR CLEAN Registry Investigators (2022). Aspiration Versus Stent Retriever Thrombectomy for Posterior Circulation Stroke. Stroke, 53(3), 749-757. https://doi.org/10.1161/strokeaha.121.034926
- van den Berg, L. A., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., Lingsma, H., Majoie, C. B. M., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Roos, Y. B., Dijkgraaf, M. G. W., & MR CLEAN Investigators (2022). Economic Evaluation of Endovascular Treatment for Acute Ischemic Stroke. Stroke, 53(3), 968-975. Article STROKEAHA121034599. https://doi.org/10.1161/strokeaha.121.034599
- Pirson, F. A. V., Boodt, N., Brouwer, J., Bruggeman, A. A. E., den Hartog, S. J., Goldhoorn, R.-J. B., Langezaal, L. C. M., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Coutinho, J. M., Emmer, B. J., Dippel, D. W. J., van der Lugt, A., Vos, J.-A., van Oostenbrugge, R. J., Schonewille, W. J., & MR CLEAN Registry Investigators (2022). Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry. Stroke, 53(3), 758-768. Article STROKEAHA121034786. https://doi.org/10.1161/strokeaha.121.034786
- Kremers, F., Venema, E., Duvekot, M., Yo, L., Bokkers, R., Nijeholt, G. L. A., van Es, A., van der Lugt, A., Majoie, C., Burke, J., Roozenbeek, B., Lingsma, H., Dippel, D., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., van Zwam, W., Goldhoorn, R.-J., Hinsenveld, W., & Staals, J. (2022). Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation. Stroke, 53(3), 825-836. https://doi.org/10.1161/STROKEAHA.120.033445
- Tolhuisen, M. L., Ernst, M., Boers, A. M. M., Brown, S., Beenen, L. F. M., Guillemin, F., Roos, Y. B. W. E. M., Saver, J. L., van Oostenbrugge, R., Demchuck, A. M., van Zwam, W., Jovin, T. G., Berkhemer, O. A., Muir, K. W., Bracard, S., Campbell, B. C. V., Van der Lugt, A., White, P., Hill, M. D., ... HERMES Collaboration (2022). Value of infarct location in the prediction of functional outcome in patients with an anterior large vessel occlusion: results from the HERMES study. Neuroradiology, 64(3), 521-530. https://doi.org/10.1007/s00234-021-02784-x
- Schievink, S. H. J., van Boxtel, M. P. J., Deckers, K., van Oostenbrugge, R. J., Verhey, F. R. J., & Kohler, S. (2022). Cognitive changes in prevalent and incident cardiovascular disease: a 12-year follow-up in the Maastricht Aging Study (MAAS). European Heart Journal, 43(7), E2-E9. https://doi.org/10.1093/eurheartj/ehx365
- Wouters, A., Robben, D., Christensen, S., Marquering, H. A., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Dippel, D. W. J., Majoie, C. B. L. M., Schonewille, W. J., van Der Lugt, A., Lansberg, M., Albers, G. W., Suetens, P., & Lemmens, R. (2022). Prediction of Stroke Infarct Growth Rates by Baseline Perfusion Imaging. Stroke, 53(2), 569-577. https://doi.org/10.1161/strokeaha.121.034444
- Crombag, G. A. J. C., Aizaz, M., Schreuder, F. H. B. M., Benali, F., Van Dam-Nolen, D. H. K., Liem, M. I. L., Lucci, C., van der Steen, A. F., Daemen, M. J. A. P., Mess, W. H., van der Lugt, A., Nederkoorn, P. J., Hendrikse, J., Hofman, P. A. M., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2022). Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage: The Plaque at Risk Study. American Journal of Neuroradiology, 43(2), 265-271. https://doi.org/10.3174/ajnr.A7384
- van Dinther, M., Schram, M. T., Jansen, J. F. A., Backes, W. H., Houben, A. J. H. M., Berendschot, T. T. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., van Oostenbrugge, R. J., & Staals, J. (2022). Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience, 44(1), 147-157. https://doi.org/10.1007/s11357-021-00493-0
- Benali, F., Stolze, L. J., Rozeman, A. D., Dinkelaar, W., Coutinho, J. M., Emmer, B. J., Gons, R. A. R., Yo, L. F. S., van Tuijl, J. H., Boukrab, I., van Dam-Nolen, D. H. K., van den Wijngaard, I. R., Nijeholt, G. J. L. A., de Laat, K. F., van Dijk, L. C., den Hertog, H. M., Flach, H. Z., Wermer, M. J. H., van Walderveen, M. A. A., ... van Oostenbrugge, R. J. (2022). Impact of the lockdown on acute stroke treatments during the first surge of the COVID-19 outbreak in the Netherlands. BMC Neurology, 22(1), Article 22. https://doi.org/10.1186/s12883-021-02539-4
- van der Ende, N. A. M., Roozenbeek, B., Berkhemer, O. A., Koudstaal, P. J., Boiten, J., van Dijk, E. J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Majoie, C. B. L. M., van Zwam, W., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., & MR CLEAN Investigators (2022). Added Value of a Blinded Outcome Adjudication Committee in an Open-Label Randomized Stroke Trial. Stroke, 53(1), 61-69. https://doi.org/10.1161/STROKEAHA.121.035301
- Brouwer, J., Smaal, J. A., Emmer, B. J., de Ridder, I. R., van den Wijngaard, I. R., de Leeuw, F. E., Hofmeijer, J., van Zwam, W. H., Martens, J. M., Roos, Y. B. W. E. M., Majoie, C. B., van Oostenbrugge, R. J., Coutinho, J. M., & MR CLEAN Registry Investigators (2022). Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study. Stroke, 53(1), 34-42. https://doi.org/10.1161/strokeaha.120.034033
- Biesbroek, J. M., Weaver, N. A., Aben, H. P., Kuijf, H. J., Abrigo, J., Bae, H.-J., Barbay, M., Best, J. G., Bordet, R., Chappell, F. M., Chen, C. P. L. H., Dondaine, T., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kang, Y., ... Biessels, G. J. (2022). Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke. NeuroImage: Clinical, 34, Article 103018. https://doi.org/10.1016/j.nicl.2022.103018
2021
- Amini, M., den Hartog, S. J., van Leeuwen, N., Eijkenaar, F., Kuhrij, L. S., Stolze, L. J., Nederkoorn, P. J., Lingsma, H. F., van Es, A. C. G. M., van den Wijngaard, I. R., van der Lugt, A., Dippel, D. W. J., Roozenbeek, B., PERFEQTOS Investigators, van Zwam, W., & van Oostenbrugge, R. J. (2021). Performance feedback on the quality of care in hospitals performing thrombectomy for ischemic stroke (PERFEQTOS): protocol of a stepped wedge cluster randomized trial. Trials, 22(1), Article 870. https://doi.org/10.1186/s13063-021-05819-z
- van Meenen, L. C. C., den Hartog, S. J., Groot, A. E., Emmer, B. J., Smeekes, M. D., Siegers, A., Kommer, G. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Es, A. C. G. M., Dippel, D. W., van der Worp, H. B., Lingsma, H. F., Roozenbeek, B., Coutinho, J. M., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., van Zwam, W., Hinsenveld, W., ... Postma - Jacobi, L. (2021). Relationship between primary stroke center volume and time to endovascular thrombectomy in acute ischemic stroke. European Journal of Neurology, 28(12), 4031-4038. https://doi.org/10.1111/ene.15107
- LeCouffe, N. E., Kappelhof, M., Treurniet, K. M., Rinkel, L. A., Bruggeman, A. E., Berkhemer, O. A., Wolff, L., van Voorst, H., Tolhuisen, M. L., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M., Boiten, J., Nijeholt, G. J. L. A., Keizer, K., Gons, R. A. R., Yo, L. S. F., van Oostenbrugge, R. J., van Zwam, W. H., ... MR CLEAN-NO IV Investigators (2021). A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke. New England Journal of Medicine, 385(20), 1833-1844. https://doi.org/10.1056/nejmoa2107727
- van der Bruggen, M. M., Kremers, B., van Oerle, R., van Oostenbrugge, R. J., & ten Cate, H. (2021). Potential value of the calibrated automated thrombogram in patients after a cerebral venous sinus thrombosis; an exploratory study. Thrombosis Journal, 19(1), Article 81. https://doi.org/10.1186/s12959-021-00335-1
- Luijten, S. P. R., van der Donk, S. C., Compagne, K. C. J., Yo, L. S. F., Sprengers, M. E. S., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Zwam, W. H., van Oostenbrugge, R., Dippel, D. W. J., van der Lugt, A., Roozenbeek, B., Bos, D., & MR CLEAN Registry Investigators (2021). Intracranial carotid artery calcification subtype and collaterals in patients undergoing endovascular thrombectomy. Atherosclerosis, 337, 1-6. https://doi.org/10.1016/j.atherosclerosis.2021.10.005
- Konduri, P., van Voorst, H., Bucker, A., van Kranendonk, K., Boers, A., Treurniet, K., Berkhemer, O., Yoo, A. J., van Zwam, W., van Oostenbrugge, R., van der Lugt, A., Dippel, D., Roos, Y., Bot, J., Majoie, C., Marquering, H., & MR CLEAN Trial Investigators (2021). Posttreatment Ischemic Lesion Evolution Is Associated With Reduced Favorable Functional Outcome in Patients With Stroke. Stroke, 52(11), 3523-3531. https://doi.org/10.1161/strokeaha.120.032331
- Samuels, N., van de Graaf, R. A., van den Berg, C. A. L., Venema, S. M. U., Bala, K., van Doormaal, P. J., van der Steen, W., Witvoet, E., Boiten, J., den Hertog, H., Schonewille, W. J., Hofmeijer, J., Schreuder, F., Schreuder, T. A. H. C. M. L., van der Worp, H. B., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Burke, J. F., van Es, A. C. G. M., ... Postma - Jacobi, L. (2021). Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome. Stroke, 52(11), 3514-3522. https://doi.org/10.1161/STROKEAHA.120.033657
- Canjels, L. P. W., Jansen, J. F. A., van den Kerkhof, M., Alers, R.-J., Poser, B. A., Wiggins, C. J., Schiffer, V. M. M. M., van de Ven, V., Rouhl, R. P. W., Palm, W. M., van Oostenbrugge, R. J., Aldenkamp, A. P., Ghossein-Doha, C., Spaanderman, M. E. A., & Backes, W. H. (2021). 7T dynamic contrast-enhanced MRI for the detection of subtle blood-brain barrier leakage. Journal of Neuroimaging, 31(5), 902-911. https://doi.org/10.1111/jon.12894
- Venema, E., Roozenbeek, B., Mulder, M. J. H. L., Brown, S., Majoie, C. B. L. M., Steyerberg, E. W., Demchuk, A. M., Muir, K. W., Davalos, A., Mitchell, P. J., Bracard, S., Berkhemer, O. A., Nijeholt, G. J. L. A., van Oostenbrugge, R. J., Roos, Y. B. W. E. M., van Zwam, W. H., van Der Lugt, A., Hill, M. D., White, P., ... MR CLEAN Registry Investigators (2021). Prediction of Outcome and Endovascular Treatment Benefit Validation and Update of the MR PREDICTS Decision Tool. Stroke, 52(9), 2764-2772. https://doi.org/10.1161/STROKEAHA.120.032935
- Nies, K. P. H., Smits, L. J. M., Kassem, M., Nederkoorn, P. J., van Oostenbrugge, R. J., & Kooi, M. E. (2021). Emerging Role of Carotid MRI for Personalized Ischemic Stroke Risk Prediction in Patients With Carotid Artery Stenosis. Frontiers in Neurology, 12, Article 718438. https://doi.org/10.3389/fneur.2021.718438
- Kerkhofs, D., Wong, S. M., Zhang, E., Uiterwijk, R., Hoff, E. I., Jansen, J. F. A., Staals, J., Backes, W. H., & van Oostenbrugge, R. J. (2021). Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study. Geroscience, 43(4), 1643-1652. https://doi.org/10.1007/s11357-021-00399-x
- Konduri, P., van Kranendonk, K., Boers, A., Treurniet, K., Berkhemer, O., Yoo, A. J., van Zwam, W., van Oostenbrugge, R., van der Lugt, A., Dippel, D., Roos, Y., Bot, J., Majoie, C., Marquering, H., & MR CLEAN Trial Investigators (2021). The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke. Frontiers in Neurology, 12, Article 705221. https://doi.org/10.3389/fneur.2021.705221
- Guglielmi, V., Compagne, K. C. J., Sarrami, A. H., Sluis, W. M., van den Berg, L. A., van der Sluijs, P. M., Mandell, D. M., van der Lugt, A., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Dippel, D. W. J., Emmer, B. J., van Es, A. C. G. M., Coutinho, J. M., MR CLEAN Trial MR CLEAN Registry, van Oostenbrugge, R. J., van Zwam, W., Staals, J., Goldhoorn, R.-J., & Hinsenveld, W. (2021). Assessment of Recurrent Stroke Risk in Patients With a Carotid Web. JAMA Neurology, 78(7), 826-833. https://doi.org/10.1001/jamaneurol.2021.1101
- Collette, S. L., Uyttenboogaart, M., Samuels, N., van der Schaaf, I. C., van der Worp, H. B., Luijckx, G. J. R., Venema, A. M., Sahinovic, M. M., Dierckx, R. A. J. O., Lingsma, H. F., Kappen, T. H., Bokkers, R. P. H., MR CLEAN Registry Investigators, Dippel, D. W. J., van der Lugt, A., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., ... Lo, R. H. (2021). Hypotension during endovascular treatment under general anesthesia for acute ischemic stroke. PLOS ONE, 16(6), Article e0249093. https://doi.org/10.1371/journal.pone.0249093
- Tolhuisen, M. L., Kappelhof, M., Dutra, B. G., Jansen, I. G. H., Guglielmi, V., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., van der Lugt, A., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Caan, M. W. A., Marquering, H. A., & MR CLEAN Registry Investigators (2021). Influence of Onset to Imaging Time on Radiological Thrombus Characteristics in Acute Ischemic Stroke. Frontiers in Neurology, 12, Article 693427. https://doi.org/10.3389/fneur.2021.693427
- Weaver, N. A., Kuijf, H. J., Aben, H. P., Abrigo, J., Bae, H. J., Barbay, M., Best, J. G., Bordet, R., Chappell, F. M., Chen, C. P. L. H., Dondaine, T., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Wajer, I. M. C. H., Kang, Y., Kappelle, L. J., ... Biessels, G. J. (2021). Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurology, 20(6), 448-459. https://doi.org/10.1016/S1474-4422(21)00060-0
- Kappelhof, N., Ramos, L. A., Kappelhof, M., van Os, H. J. A., Chalos, V., van Kranendonk, K. R., Kruyt, N. D., Roos, Y. B. W. E. M., van Zwam, W. H., van der Schaaf, I. C., van Walderveen, M. A. A., Wermer, M. J. H., van Oostenbrugge, R. J., Lingsma, H., Dippel, D., Majoie, C. B. L. M., & Marquering, H. A. (2021). Evolutionary algorithms and decision trees for predicting poor outcome after endovascular treatment for acute ischemic stroke. Computers in Biology and Medicine, 133, Article 104414. https://doi.org/10.1016/j.compbiomed.2021.104414
- Almekhlafi, M. A., Goyal, M., Dippel, D. W. J., Majoie, C. B. L. M., Campbell, B. C. V., Muir, K. W., Demchuk, A. M., Bracard, S., Guillemin, F., Jovin, T. G., Mitchell, P., White, P., Hill, M. D., Brown, S., Saver, J. L., HERMES Trialists Collaboration, van Zwam, W., & van Oostenbrugge, R. J. (2021). Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials. JAMA Neurology, 78(6), 709-717. https://doi.org/10.1001/jamaneurol.2021.1055
- van de Graaf, R. A., Zinkstok, S. M., Chalos, V., Goldhoorn, R.-J. B., Majoie, C. B. L. M., van Oostenbrugge, R. J., van der Lugt, A., Dippel, D. W. J., Roos, Y. B., Lingsma, H. F., van Es, A. C. G. M., Roozenbeek, B., MR CLEAN Registry Investigators, & van Zwam, W. (2021). Prior antiplatelet therapy in patients undergoing endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry. International journal of stroke, 16(4), 476-485. https://doi.org/10.1177/1747493020946975
- Duvekot, M. H. C., Venema, E., Lingsma, H. F., Coutinho, J. M., van der Worp, H. B., Hofmeijer, J., Bokkers, R. P. H., van Es, A. C. G. M., van der Lugt, A., Kerkhoff, H., Dippel, D. W. J., Roozenbeek, B., MR CLEAN Registry Investigators, Postma - Jacobi, L., van Oostenbrugge, R. J., van Zwam, W., & Goldhoorn, R.-J. (2021). Sensitivity of prehospital stroke scales for different intracranial large vessel occlusion locations. European Stroke Journal, 6(2), 194-204. https://doi.org/10.1177/23969873211015861
- van den Kerkhof, M., Voorter, P. H. M., Canjels, L. P. W., de Jong, J. J. A., van Oostenbrugge, R. J., Kroon, A. A., Jansen, J. F. A., & Backes, W. H. (2021). Time-efficient measurement of subtle blood-brain barrier leakage using a T-1 mapping MRI protocol at 7 T. Magnetic Resonance in Medicine, 85(5), 2761-2770. https://doi.org/10.1002/mrm.28629
- Kerkhofs, D., Wong, S. M., Zhang, E. L. A. N., Staals, J., Jansen, J. F. A., van Oostenbrugge, R. J., & Backes, W. H. (2021). Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities. Neurology, 96(17), E2192-E2200. https://doi.org/10.1212/WNL.0000000000011783
- Best, J. G., Ambler, G., Wilson, D., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L. X., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martinez-Domeno, A., Inamura, S., Yoshifuji, K., Arsava, E. M., Horstmann, S., ... Werring, D. J. (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurology, 20(4), 294-303. https://doi.org/10.1016/S1474-4422(21)00024-7
- van Tuijl, J. H., van Raak, E. P. M., van Oostenbrugge, R. J., Aldenkamp, A. P., & Rouhl, R. P. W. (2021). Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial. Cerebrovascular Diseases, 50(2), 216-221. https://doi.org/10.1159/000512799
- Pirson, F. A. V., Hinsenveld, W. H., Goldhoorn, R. J. B., Staals, J., de Ridder, I. R., van Zwam, W. H., van Walderveen, M. A. A., Nijeholt, G. J. L. A., Uyttenboogaart, M., Schonewille, W. J., van der Lugt, A., Dippel, D. W. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., van Oostenbrugge, R. J., & MR CLEAN-LATE Investigators (2021). MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial. Trials, 22(1), Article 160. https://doi.org/10.1186/s13063-021-05092-0
- Treurniet, K. M., LeCouffe, N. E., Kappelhof, M., Emmer, B. J., van Es, A. C. G. M., Boiten, J., Lycklama, G. J., Keizer, K., Yo, L. S. F., Lingsma, H. F., van Zwam, W. H., de Ridder, I., van Oostenbrugge, R. J., van der Lugt, A., Dippel, D. W. J., Coutinho, J. M., Roos, Y. B. W. E. M., Majoie, C. B. L. M., & MR CLEAN-NO IV Investigators (2021). MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion-study protocol for a randomized clinical trial. Trials, 22(1), Article 141. https://doi.org/10.1186/s13063-021-05063-5
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