Publications
- 2023
- Juni, R. P., Kocken, J. M. M., Abreu, R. C., Ottaviani, L., Davalan, T., Duygu, B., Poels, E. M., Vasilevich, A., Hegenbarth, J. C., Appari, M., Bitsch, N., Olieslagers, S., Schrijvers, D. M., Stoll, M., Heineke, J., de Boer, J., de Windt, L. J., & da Costa, P. A. (2023). MicroRNA-216a is essential for cardiac angiogenesis. Molecular Therapy, 31(6), 1807-1828. https://doi.org/10.1016/j.ymthe.2023.04.007
- ter Bekke, R. M. A., de Schouwer, K., Conti, S., Claes, G. R. F., Vanoevelen, J., Gommers, S., Helderman-van den Enden, A. T. J. M., & Brunner-LaRocca, H.-P. (2023). Juvenile-onset multifocal atrial arrhythmias, atrial standstill and compound heterozygosity of genetic variants in TAF1A: sentinel event for evolving dilated cardiomyopathy-a case report. European Heart Journal - Case Reports, 7(6), Article ytad255. https://doi.org/10.1093/ehjcr/ytad255
- Sikking, M. A., Stroeks, S. L. V. M., Henkens, M. T. H. M., Venner, M. F. G. H. M., Li, X., Heymans, S. R. B., Hazebroek, M. R., & Verdonschot, J. A. J. (2023). Cardiac Inflammation in Adult-Onset Genetic Dilated Cardiomyopathy. Journal of Clinical Medicine, 12(12), Article 3937. https://doi.org/10.3390/jcm12123937
- Steiner, B., Neumann, A., Pelz, Y., Ski, C. F., Hill, L., Thompson, D. R., Fitzsimons, D., Dixon, L. J., Brandts, J., Verket, M., Schuett, K., Eurlings, C. G. M. J., Boyne, J. J. J., Gingele, A. J., De Maesschalck, L., Murphy, M., da Luz, E. F., Barrett, M., Windle, K., ... PASSION-HF consortium (2023). Challenges in heart failure care in four European countries: a comparative study. European Journal of Public Health, 33(3), 448-454. https://doi.org/10.1093/eurpub/ckad059
- Linders, A. N., Dias, I. B., Ovchinnikova, E. S., Vermeer, M. C. S. C., Hoes, M. F., Mavrogenis, G. M., Deiman, F. E., Gomez, K. F. A., Bliley, J. M., Nehme, J., Vink, A., Gietema, J., de Boer, R. A., Westenbrink, D., Sillje, H. H. W., Hilfiker-Kleiner, D., van Laake, L. W., Feinberg, A. W., Demaria, M., ... van der Meer, P. (2023). Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues. JACC: CardioOncology, 5(3), 298-315. https://doi.org/10.1016/j.jaccao.2023.03.012
- Vroemen, W. H. M., van Beers, J. J. B. C., Frissen, J., & de Wit, N. C. J. (2023). Hypo-osmolality and its effect on erythrocyte parameters. International Journal of Laboratory Hematology, 45(3), e93-e94. https://doi.org/10.1111/ijlh.14022
- Vermeer, M. C. S. C., Arevalo Gomez, K. F., Hoes, M. F., Tromp, J., Verdonschot, J. A. J., Henkens, M. T. H. M., Silljé, H. H. W., Bolling, M. C., & van der Meer, P. (2023). Clinical Outcome in KLHL24 Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(4), 401-403. https://doi.org/10.1161/CIRCGEN.122.003998
- Kerstens, T. P., Weerts, J., van Dijk, A. P. J., Weijers, G., Knackstedt, C., Eijsvogels, T. M. H., Oxborough, D., van Empel, V. P. M., & Thijssen, D. H. J. (2023). Left ventricular strain-volume loops and diastolic dysfunction in suspected heart failure with preserved ejection fraction. International Journal of Cardiology, 378(1), 144-150. https://doi.org/10.1016/j.ijcard.2023.01.084
- Girerd, N., Levy, D., Duarte, K., Ferreira, J. P., Ballantyne, C., Collier, T., Pizard, A., Björkman, J., Butler, J., Clark, A., Cleland, J. G., Delles, C., Diez, J., González, A., Hazebroek, M., Ho, J., Huby, A. C., Hwang, S. J., Latini, R., ... Zannad, F. (2023). Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circulation-Heart Failure, 16(5), 426-441. Article e009694. https://doi.org/10.1161/CIRCHEARTFAILURE.122.009694
- Knackstedt, C., Schummers, G., Schroder, J., Marx, N., Lumens, J., Sanders-van Wijk, S., Ramaekers, B., Becker, M., van Empel, V., Brunner-La Rocca, H. P., & PsychEcho study group (2023). A graphical analysis of aspects contributing to the spreading of measurements of left ventricular function. International Journal of Cardiovascular Imaging, 39(5), 915-927. https://doi.org/10.1007/s10554-023-02796-z
- Starmans, N. L., Wolters, F. J., Leeuwis, A. E., Bron, E. E., La Rocca, H. P. B., Staals, J., Biessels, G. J., & Kappelle, L. J. (2023). Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities. Journal of Cerebral Blood Flow and Metabolism, 43(5), 801-811. https://doi.org/10.1177/0271678X221149937
- Verdonschot, J. A. J., Wang, P., Derks, K. W. J., Adriaens, M. E., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Sikking, M., de Koning, B., van den Wijngaard, A., Krapels, I. P. C., Nabben, M., Brunner, H. G., & Heymans, S. R. B. (2023). Clustering of Cardiac Transcriptome Profiles Reveals Unique Subgroups of Dilated Cardiomyopathy Patients. JACC: Basic to Translational Science, 8(4), 406-418. https://doi.org/10.1016/j.jacbts.2022.10.010
- Haenen, G. R. M. M. (2023). Past, Present and Future of the Section "Molecular Toxicology". International Journal of Molecular Sciences, 24(7), Article 6667. https://doi.org/10.3390/ijms24076667
- Stroeks, S. L. V. M., Lunde, I. G. G., Hellebrekers, D. M. E. I., Claes, G. R. F., Wakimoto, H., Gorham, J., Krapels, I. P. C., Vanhoutte, E. K. K., van den Wijngaard, A., Henkens, M. T. H. M., Raafs, A. G. G., Sikking, M. A. A., Broers, J. L. V., Nabben, M., Jones, E. A. V., Heymans, S. R. B., Brunner, H. G. G., & Verdonschot, J. A. J. (2023). Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(2), Article e003788. https://doi.org/10.1161/CIRCGEN.122.003788
- Clephas, P. R. D., Radhoe, S. P., Linssen, G. C. M., Langerveld, J., Plomp, J., Smits, J. P. P., Nagelsmit, M. J., Rocca, H. P. B. L., & Brugts, J. J. (2023). Serum potassium level and mineralocorticoid receptor antagonist dose in a large cohort of chronic heart failure patients. Esc heart failure, 10(2), 1481-1487. https://doi.org/10.1002/ehf2.14285
- Donker, E. M., Pandit, R., Poleij, M. C. S., Brinkman, D. J., van Agtmael, M. A., van Rosse, F., Dumont, G., Kramers, C., Atiqi, R., Richir, M. C., van Smeden, J., Hessel, M. H. M., Janssen, B. J., Knol, W., Tichelaar, J., & Pharmacotherapy Education working group of the Dutch Society for Clinical Pharmacology & Biopharmacy and its affiliated Dutch Network of Clinical Pharmacology Teachers (2023). The Dutch list of essential drugs for undergraduate medical education: A modified Delphi study. British Journal of Clinical Pharmacology, 89(4), 1431-1451. https://doi.org/10.1111/bcp.15606
- Soragni, C., Vergroesen, T., Hettema, N., Rabussier, G., Lanz, H. L., Trietsch, S. J., de Windt, L. J., & Ng, C. P. (2023). Quantify permeability using on-a-chip models in high-throughput applications. STAR protocols, 4(1), Article 102051. https://doi.org/10.1016/j.xpro.2023.102051
- Ferreira, J. P., Cleland, J. G. F., Girerd, N., Pellicori, P., Hazebroek, M. R., Verdonschot, J., Collier, T. J., Petutschnigg, J., Clark, A. L., Staessen, J. A., Heymans, S., Rossignol, P., & Zannad, F. (2023). Effect of Spironolactone on QRS Duration in Patients at Risk for Heart Failure (from the HOMAGE Trial). American Journal of Cardiology, 191(1), 39-42. https://doi.org/10.1016/j.amjcard.2022.12.016
- Robinson, E. L., Ameri, P., Delrue, L., Vanderheyden, M., Bartunek, J., Altieri, P., Heymans, S., & Heggermont, W. A. (2023). Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity. Frontiers in Cardiovascular Medicine, 10(1), Article 884174. https://doi.org/10.3389/fcvm.2023.884174
- Radhoe, S. P., Clephas, P. R. D., Linssen, G. C. M., Oortman, R. M., Smeele, F. J., Van Drimmelen, A. A., Schaafsma, H. J., Westendorp, P. H., Rocca, H. P. B. L., & Brugts, J. J. (2023). Phenotypic patient profiling for improved implementation of guideline-directed medical therapy: An exploratory analysis in a large real-world chronic heart failure cohort. Frontiers in Pharmacology, 14(1), Article 1081579. https://doi.org/10.3389/fphar.2023.1081579
- de Boer, M., Hekkert, M. T., Chang, J., van Thiel, B. S., Martens, L., Bos, M. M., de Kleijnen, M. G. J., Ridwan, Y., Octavia, Y., van Deel, E. D., Blonden, L. A., Brandt, R. M. C., Barnhoorn, S., Bautista-Nino, P. K., Krabbendam-Peters, I., Wolswinkel, R., Arshi, B., Ghanbari, M., Kupatt, C., ... Duncker, D. J. (2023). DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice. Aging Cell, 22(3), Article e13768. https://doi.org/10.1111/acel.13768
- Sanchez-Aguilera, P., Lopez-Crisosto, C., Norambuena-Soto, I., Penannen, C., Zhu, J. M., Bomer, N., Hoes, M. F., van der Meer, P., Chiong, M., Westenbrink, B. D., & Lavandero, S. (2023). IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes. Frontiers in physiology, 14(1), Article 1106662. https://doi.org/10.3389/fphys.2023.1106662
- Gyöngyösi, M., Alcaide, P., Asselbergs, F. W., Brundel, B. J. J. M., Camici, G. G., da Costa Martins, P., Ferdinandy, P., Fontana, M., Girao, H., Gnecchi, M., Gollmann-Tepeköylü, C., Kleinbongard, P., Krieg, T., Madonna, R., Paillard, M., Pantazis, A., Perrino, C., Pesce, M., Schiattarella, G. G., ... Davidson, S. M. (2023). Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases. Cardiovascular Research, 119(2), 336-356. Article cvac115. https://doi.org/10.1093/cvr/cvac115
- Ferreira, J. P., Cleland, J. G. F., Girerd, N., Pellicori, P., Hazebroek, M. R., Verdonschot, J., Collier, T. J., Petutschnigg, J., Clark, A. L., Staessen, J. A., Heymans, S., Zannad, F., & Rossignol, P. (2023). Early and late renal function changes with spironolactone in patients at risk of developing heart failure: findings from the HOMAGE trial. Clinical research in cardiology, 112(2), 330-332. https://doi.org/10.1007/s00392-022-02116-w
- Nuzzi, V., Raafs, A., Manca, P., Henkens, M. T. H. M., Gregorio, C., Boscutti, A., Verdonschot, J., Hazebroek, M., Knackstedt, C., Merlo, M., Stolfo, D., Sinagra, G., & Heymans, S. R. B. (2023). Left Atrial Reverse Remodeling in Dilated Cardiomyopathy. Journal of the American Society of Echocardiography, 36(2), 154-162. https://doi.org/10.1016/j.echo.2022.10.017
- van Beek, D., Verdonschot, J., Derks, K., Brunner, H., de Kok, T., Arts, I., Heymans, S., Kutmon, M., & Adriaens, M. (2023). Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort. Scientific Reports, 13(1), Article 564. https://doi.org/10.1038/s41598-023-27591-7
- Rohr, M., Brandenburg, V., & Rocca, H. P. B. (2023). How to diagnose iron deficiency in chronic disease: A review of current methods and potential marker for the outcome. European Journal of Medical Research, 28(1), Article 15. https://doi.org/10.1186/s40001-022-00922-6
- Scherrenberg, M., Leenen, J. P. L., van der Velde, A. E., Boyne, J., Bruins, W., Vranken, J., Brunner-La Rocca, H. P., De Kluiver, E. P., & Dendale, P. (2023). Bringing the hospital to home: Patient-reported outcome measures of a digital health-supported home hospitalisation platform to support hospital care at home for heart failure patients. Digital health, 9(1), 1-10. Article 20552076231152178. https://doi.org/10.1177/20552076231152178
- Gürgöze, M. T., van Vark, L. C., Baart, S. J., Kardys, I., Akkerhuis, K. M., Manintveld, O. C., Postmus, D., Hillege, H. L., Lesman-Leegte, I., Asselbergs, F. W., Brunner-la-Rocca, H.-P., van den Bos, E. J., Orsel, J. G., de Ridder, S. P. J., Pinto, Y. M., & Boersma, E. (2023). Multimarker Analysis of Serially Measured GDF-15, NT-proBNP, ST2, GAL-3, cTnI, Creatinine, and Prognosis in Acute Heart Failure. Circulation-Heart Failure, 16(1), Article e009526. https://doi.org/10.1161/CIRCHEARTFAILURE.122.009526
- Timmermans, E. J., Leeuwis, A. E., Bots, M. L., van Alphen, J. L., Biessels, G. J., Brunner-La Rocca, H.-P., Kappelle, L. J., van Rossum, A. C., van Osch, M. J. P., Vaartjes, I., & Heart-Brain Connection Consortium (2023). Neighbourhood walkability in relation to cognitive functioning in patients with disorders along the heart-brain axis. Health & Place, 79(1), Article 102956. https://doi.org/10.1016/j.healthplace.2022.102956
- Vilaça, A., de Windt, L. J., Fernandes, H., & Ferreira, L. (2023). Strategies and challenges for non-viral delivery of non-coding RNAs to the heart. Trends in Molecular Medicine, 29(1), 70-91. https://doi.org/10.1016/j.molmed.2022.10.002
- Baldewijns, K., Boyne, J., Rohde, C., de Maesschalck, L., Devillé, A., Brandenburg, V., De Bleser, L., Derickx, M., Bektas, S., & Brunner-La Rocca, H.-P. (2023). What kind of patient education and self-care support do patients with heart failure receive, and by whom? Implementation of the ESC guidelines for heart failure in three European regions. Heart & Lung, 57(1), 25-30. https://doi.org/10.1016/j.hrtlng.2022.07.013
- 2022
- Hegenbarth, J. C., De Majo, F., Spano, G., Olieslagers, S., Esfandyari, D., Tiburcy, M., Zimmermann, W. H., Stoll, M., & de Windt, L. (2022). Machine learning-assisted integration of single cell transcriptomic data identifies potential cardiomyocyte maturation genes. Journal of Molecular and Cellular Cardiology, 173, S47-S47. https://doi.org/10.1016/j.yjmcc.2022.08.094
- Spano, G., Hegenbarth, J. C., De Majo, F., Tiburcy, M., Zimmermann, W. H., & de Windt, L. (2022). RNA m6A modification governs early human cardiomyocyte commitment. Journal of Molecular and Cellular Cardiology, 173, S108-S109. https://doi.org/10.1016/j.yjmcc.2022.08.215
- Rypdal, K. B., Olav Melleby, A., Robinson, E. L., Li, J., Palmero, S., Seifert, D. E., Martin, D., Clark, C., López, B., Andreassen, K., Dahl, C. P., Sjaastad, I., Tønnessen, T., Stokke, M. K., Louch, W. E., González, A., Heymans, S., Christensen, G., Apte, S. S., & Lunde, I. G. (2022). ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Communications Biology, 5(1), Article 1392. https://doi.org/10.1038/s42003-022-04361-1
- Fanti, S., Stephenson, E., Rocha-Vieira, E., Protonotarios, A., Kanoni, S., Shahaj, E., Paula Longhi, M., Vyas, V. S., Dyer, C., Pontarini, E., Asimaki, A., Bueno-Beti, C., De Gaspari, M., Rizzo, S., Basso, C., Bombardieri, M., Coe, D., Wang, G., Harding, D., ... Marelli-Berg, F. M. (2022). Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity. Circulation, 146(25), 1930-1945. https://doi.org/10.1161/CIRCULATIONAHA.121.055610
- van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., ... Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016-3051. https://doi.org/10.1093/cvr/cvab370
- Anker, S. D., Butler, J., Usman, M. S., Filippatos, G., Ferreira, J. P., Bocchi, E., Böhm, M., Rocca, H. P. B.-L., Choi, D.-J., Chopra, V., Chuquiure, E., Giannetti, N., Gomez-Mesa, J. E., Janssens, S., Januzzi, J. L., González-Juanatey, J. R., Merkely, B., Nicholls, S. J., Perrone, S. V., ... Zannad, F. (2022). Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved. Nature Medicine, 28(12), 2512–2520. https://doi.org/10.1038/s41591-022-02041-5
- Donker, E. M., Brinkman, D. J., van Rosse, F., Janssen, B., Knol, W., Dumont, G., Jorens, P. G., Dupont, A., Christiaens, T., van Smeden, J., de Waard-Siebinga, I., Peeters, L. E. J., Goorden, R., Hessel, M., Lissenberg-Witte, B., Richir, M., van Agtmael, M., Kramers, C., Tichelaar, J., & Education committee of the Dutch Society for Clinical Pharmacology and Biopharmacy (2022). Do we become better prescribers after graduation: A 1-year international follow-up study among junior doctors. British Journal of Clinical Pharmacology, 88(12), 5218-5226. https://doi.org/10.1111/bcp.15443
- Monzo, L., Ferreira, J. P., Cleland, J. G. F., Pellicori, P., Mariottoni, B., Hazebroek, M. R., Collier, T. J., Cuthbert, J. J., Pieske, B., Petutschnigg, J., Ahmed, F. Z., Girerd, N., Clark, A. L., Cosmi, F., Staessen, J. A., Heymans, S., Rossignol, P., & Zannad, F. (2022). Dyskalemia in people at increased risk for heart failure: findings from the heart 'OMics' in AGEing (HOMAGE) trial. Esc heart failure, 9(6), 4352-4357. https://doi.org/10.1002/ehf2.14086
- Carai, P., Florit González, L., Van Bruggen, S., Spalart, V., De Giorgio, D., Geuens, N., Martinod, K., Jones, E. A. V., & Heymans, S. (2022). NEUTROPHIL INHIBITION IMPROVES ACUTE INFLAMMATION IN A MURINE MODEL OF VIRAL MYOCARDITIS. Cardiovascular Research, 118(17), 3331-3345. https://doi.org/10.1093/cvr/cvac052
- Kuipers, S., Greving, J. P., Brunner-La Rocca, H.-P., Gottesman, R. F., van Oostenbrugge, R. J., Williams, N. L., Jan Biessels, G., Jaap Kappelle, L., & Heart-Brain Connection Consortium (2022). Risk evaluation of cognitive impairment in patients with heart failure: A call for action. IJC Heart and Vasculature, 43, Article 101133. https://doi.org/10.1016/j.ijcha.2022.101133
- Gingele, A. J., Boyne, J., Knackstedt, C., & Brunner-La Rocca, H. P. (2022). The MIS-HF in clinical practice. Netherlands Heart Journal, 30(12), 582-583. https://doi.org/10.1007/s12471-022-01731-6
- De Windt, L. J. (2022). Grand challenges in molecular cardiology. Frontiers in Molecular Medicine, 2, Article 920039. https://doi.org/10.3389/fmmed.2022.920039
- Suresh Babu, V., Kizhakeyil, A., Dudeja, G., Chaurasia, S. S., Barathi, V. A., Heymans, S., Verma, N. K., Lakshminarayanan, R., & Ghosh, A. (2022). Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial Dodecapeptides. Pharmaceutics, 14(11), Article 2507. https://doi.org/10.3390/pharmaceutics14112507
- Xu, L., Balzarolo, M., Robinson, E. L., Lorenz, V., Verde, G. D., Joray, L., Mochizuki, M., Kaufmann, B. A., Valstar, G., de Jager, S. C. A., den Ruijter, H. M., Heymans, S., Pfister, O., & Kuster, G. M. (2022). NOX1 mediates metabolic heart disease in mice and is upregulated in monocytes of humans with diastolic dysfunction. Cardiovascular Research, 118(14), 2973-2984. https://doi.org/10.1093/cvr/cvab349
- Soragni, C., Rabussier, G., Lanz, H. L., Bircsak, K. M., de Windt, L. J., Trietsch, S. J., Murdoch, C. E., & Ng, C. P. (2022). A versatile multiplexed assay to quantify intracellular ROS and cell viability in 3D on-a-chip models. Redox Biology, 57, Article 102488. https://doi.org/10.1016/j.redox.2022.102488
- Remmelzwaal, S., van Oort, S., Handoko, M. L., van Empel, V., Heymans, S. R. B., & Beulens, J. W. J. (2022). Inflammation and heart failure: a two-sample Mendelian randomization study. Journal of Cardiovascular Medicine, 23(11), 728-735. https://doi.org/10.2459/JCM.0000000000001373
- Lim, Y. M. F., Molnar, M., Vaartjes, I., Savarese, G., Eijkemans, M. J. C., Uijl, A., Vradi, E., Suzart-Woischnik, K., Brugts, J. J., Brunner-La Rocca, H.-P., Blanc-Guillemaud, V., Couvelard, F., Baudier, C., Dyszynski, T., Waechter, S., Lund, L. H., Hoes, A. W., Tyl, B., Asselbergs, F. W., ... Koudstaal, S. (2022). Generalizability of randomized controlled trials in heart failure with reduced ejection fraction. European heart journal - Quality of care & clinical outcomes, 8(7), 761–769. https://doi.org/10.1093/ehjqcco/qcab070
- Wang, S., Neumann, D., Westenbrink, B. D., Schianchi, F., Wong, L.-Y., Sun, A., Strzelecka, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2022). Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly-Rescue by Specific Amino Acid Supplementation. International journal of molecular sciences, 23(21), Article 12909. https://doi.org/10.3390/ijms232112909