• 2016
    • Yoo, A. J., Berkhemer, O. A., Fransen, P. S. S., van den Berg, L. A., Beumer, D., Lingsma, H. F., Schonewille, W. J., Sprengers, M. E. S., van den Berg, R., van Walderveen, M. A. A., Beenen, L. F. M., Wermer, M. J. H., Nijeholt, G. J. L. A., Boiten, J., Jenniskens, S. F. M., Bot, J. C. J., Boers, A. M. M., Marquering, H. A., Roos, Y. B. W. E. M., ... Majoie, C. B. L. M. (2016). Effect of baseline Alberta Stroke Program Early CT Score on safety and efficacy of intra-arterial treatment: a subgroup analysis of a randomised phase 3 trial (MR CLEAN). Lancet Neurology, 15(7), 685-694. https://doi.org/10.1016/S1474-4422(16)00124-1
    • Nabben, M., & Neumann, D. (2016). GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?Cardiovascular Drugs and Therapy, 30(3), 233-235. https://doi.org/10.1007/s10557-016-6669-y
    • Kok, M., Mihl, C., Hendriks, B. M. F., Altintas, S., Kietselaer, B. L. J. H., Wildberger, J. E., & Das, M. (2016). Optimizing contrast media application in coronary CT angiography at lower tube voltage: Evaluation in a circulation phantom and sixty patients. European Journal of Radiology, 85(6), 1068-1074. https://doi.org/10.1016/j.ejrad.2016.03.022
    • Post, M. C., Van Dijk, A. P., Hoendermis, E. S., Bogaard, H. J., Van Empel, V., & Boomars, K. A. (2016). PulmoCor: national registry for pulmonary hypertension. Netherlands Heart Journal, 24(6), 425-426. https://doi.org/10.1007/s12471-016-0830-x
    • Klooster, D. C. W., de Louw, A. J. A., Aldenkamp, A. P., Besseling, R. M. H., Mestrom, R. M. C., Carrette, S., Zinger, S., Bergmans, J. W. M., Mess, W. H., Vonck, K., Carrette, E., Breuer, L. E. M., Bernas, A., Tijhuis, A. G., & Boon, P. (2016). Technical aspects of neurostimulation: Focus on equipment, electric field modeling, and stimulation protocols. Neuroscience and Biobehavioral Reviews, 65, 113-141. https://doi.org/10.1016/j.neubiorev.2016.02.016
    • Crijnen, Y. S., Nouwens, F., de Lau, L. M. L., Visch-Brink, E. G., van de Sandt-Koenderman, M. W. M. E., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Roos, Y. B. W. E. M., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., & Dippel, D. W. J. (2016). Early effect of intra-arterial treatment in ischemic stroke on aphasia recovery in MR CLEAN. Neurology, 86(22), 2049-2055. https://doi.org/10.1212/WNL.0000000000002724
    • Simsekyilmaz, S., Liehn, E. A., Weinandy, S., Schreiber, F., Megens, R. T. A., Theelen, W., Smeets, R., Jockenhoevel, S., Gries, T., Moeller, M., Klee, D., Weber, C., & Zernecke, A. (2016). Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice. PLOS ONE, 11(5), Article e0155829. https://doi.org/10.1371/journal.pone.0155829
    • Bouwmans, A. E. P., Weber, W. E. J., Leentjens, A. F. G., & Mess, W. H. (2016). Transcranial sonography findings related to depression in parkinsonian disorders: cross-sectional study in 126 patients. PEERJ, 4(5), Article e2037. https://doi.org/10.7717/peerj.2037
    • Beumer, D., Rozeman, A. D., Nijeholt, G. J. L. A., Brouwer, P. A., Jenniskens, S. F. M., Algra, A., Boiten, J., Schonewille, W., van Oostenbrugge, R. J., Dippel, D. W. J., & van Zwam, W. H. (2016). The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study. BMC Neurology, 16(1), Article 68. https://doi.org/10.1186/s12883-016-0592-5
    • Wichapong, K., Alard, J. .-E., Ortega-Gomez, A., Weber, C., Hackeng, T. M., Soehnlein, O., & Nicolaes, G. A. F. (2016). Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). Journal of Medicinal Chemistry, 59(9), 4289-4301. https://doi.org/10.1021/acs.jmedchem.5b01952
    • Douven, E., Schievink, S. H. J., Verhey, F. R. J., van Oostenbrugge, R. J., Aalten, P., Staals, J., & Köhler, S. (2016). The Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design. BMC Neurology, 16(1), Article 65. https://doi.org/10.1186/s12883-016-0588-1
    • Koppen, H., Palm-Meinders, I. H., Mess, W. H., Keunen, R. W., Terwindt, G. M., Launer, L. J., van Buchem, M. A., Kruit, M. C., & Ferrari, M. D. (2016). Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity. Neurology, 86(18), 1668-1675. https://doi.org/10.1212/WNL.0000000000002538
    • Haasdijk, R. A., Den Dekker, W. K., Cheng, C., Tempel, D., Szulcek, R., Bos, F. L., Hermkens, D. M. A., Chrifi, I., Brandt, M. M., Van Dijk, C., Xu, Y. J., Van De Kamp, E. H. M., Blonden, L. A. J., Van Bezu, J., Sluimer, J. C., Biessen, E. A. L., Amerongen, G. P. V. N., & Duckers, H. J. (2016). THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE(-/-) mice. Cardiovascular Research, 110(1), 129-139. https://doi.org/10.1093/cvr/cvw015
    • Yan, I., Schwarz, J., Luecke, K., Schumacher, N., Schumacher, V., Schmidt, S., Rabe, B., Saftig, P., Donners, M., Rose-John, S., Mittruecker, H.-W., & Chalaris, A. (2016). ADAM17 controls IL-6 signaling by cleavage of the murine IL-6R alpha from the cell surface of leukocytes during inflammatory responses. Journal of Leukocyte Biology, 99(5), 749-760. https://doi.org/10.1189/jlb.3A0515-207R
    • Vainer, J., Habets, J. H. M., Schalla, S., Lousberg, A. H. P., de Pont, C. D. J. M., Vöö, S., Brans, B. T., Hoorntje, J. C. A., & Waltenberger, J. (2016). Cardiac shockwave therapy in patients with chronic refractory angina pectoris. Netherlands Heart Journal, 24(5), 343-349. https://doi.org/10.1007/s12471-016-0821-y
    • Breuer, L. E. M., Boon, P., Bergmans, J. W. M., Mess, W. H., Besseling, R. M. H., de Louw, A., Tijhuis, A. G., Zinger, S., Bernas, A., Klooster, D. C. W., & Aldenkamp, A. P. (2016). Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?Neuroscience and Biobehavioral Reviews, 64, 1-11. https://doi.org/10.1016/j.neubiorev.2016.02.004
    • Gemmink, A., Bosma, M., Kuijpers, H. J. H., Hoeks, J., Schaart, G., van Zandvoort, M., Schrauwen, P., & Hesselink, M. K. C. (2016). Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia, 59(5), 1040–1048. https://doi.org/10.1007/s00125-016-3865-z
    • Vöö, S., Kwee, R. M., Sluimer, J. C., Schreuder, F. H. B. M., Wierts, R., Bauwens, M., Heeneman, S., Cleutjens, J. P. M., van Oostenbrugge, R. J., Daemen, J.-W. H., Daemen, M. J. A. P., Mottaghy, F. M., & Kooi, E. (2016). Imaging Intraplaque Inflammation in Carotid Atherosclerosis With F-18-Fluorocholine Positron Emission Tomography-Computed Tomography Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation. Circulation-Cardiovascular Imaging, 9(5), Article e004467. https://doi.org/10.1161/CIRCIMAGING.115.004467
    • Weber, C., Doering, Y., & Noels, H. (2016). Potential cell-specific functions of CXCR4 in atherosclerosis. Hämostaseologie, 36(2), 97-102. https://doi.org/10.5482/HAMO-14-10-0054
    • Goyal, M., Menon, B. K., van Zwam, W. H., Dippel, D. W. J., Mitchell, P. J., Demchuk, A. M., Davalos, A., Majoie, C. B. L. M., van der Lugt, A., de Miquel, M. A., Donnan, G. R. A., Roos, Y. B. W. E. M., Bonafe, A., Jahan, R., Diener, H.-C., van den Berg, L. A., Levy, E. I., Berkhemer, O. A., Pereira, V. M., ... Jovin, T. G. (2016). Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet, 387(10029), 1723-1731. https://doi.org/10.1016/S0140-6736(16)00163-X
    • Cardinaels, E. P. M., Altintas, S., Versteylen, M. O., Joosen, I. A., Jellema, L.-J. C., Wildberger, J. E., Das, M., Crijns, H. J., Bekers, O., van Dieijen-Visser, M. P., Kietselaer, B. L., & Mingels, A. M. A. (2016). High-Sensitivity Cardiac Troponin Concentrations in Patients with Chest Discomfort: Is It the Heart or the Kidneys As Well?PLOS ONE, 11(4), Article e0153300. https://doi.org/10.1371/journal.pone.0153300
    • Miglianico, M., Nicolaes, G. A. F., & Neumann, D. (2016). Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design. Journal of Medicinal Chemistry, 59(7), 2879-2893. https://doi.org/10.1021/acs.jmedchem.5b01201
    • Oligschläger, Y., Miglianico, M., Dahlmans, V. E., Rubio-Villena, C., Chanda, D., Adelaida Garcia-Gimeno, M., Coumans, W. A., Liu, Y., Voncken, J. W., Luiken, J. J. F. P., Glatz, J. F. C., Sanz, P., & Neumann, D. (2016). The interaction between AMPK beta 2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content. Biochemical Journal, 473(7), 937-947. https://doi.org/10.1042/BJ20151035
    • Spronck, B., Megens, R. T. A., Reesink, K. D., & Delhaas, T. (2016). A method for three-dimensional quantification of vascular smooth muscle orientation: application in viable murine carotid arteries. Biomechanics and modeling in mechanobiology, 15(2), 419-432. https://doi.org/10.1007/s10237-015-0699-4
    • Frusch, K. J. M., Houben, R., Schreuder, F. H. B. M., Postma - Jacobi, L., & Staals, J. (2016). Association between eye position on brain scan and hospital mortality in acute intracerebral hemorrhage. European Journal of Neurology, 23(4), 831-835. https://doi.org/10.1111/ene.12951
    • Maessen, D. E., Brouwers, O., Gaens, K. H., Wouters, K., Cleutjens, J. P., Janssen, B. J., Miyata, T., Stehouwer, C. D., & Schalkwijk, C. G. (2016). Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice. Diabetes, 65(4), 956-966. https://doi.org/10.2337/db15-1390
    • Kemerink, G. J., van Engelshoven, J., Simon, K. J., Kutterer, G., & Wildberger, J. E. (2016). Early X-ray workers: an effort to assess their numbers, risk, and most common (skin) affliction. Insights into Imaging, 7(2), 275-282. https://doi.org/10.1007/s13244-015-0457-2
    • Uiterwijk, R., Huijts, M., Staals, J., Rouhl, R. P. W., De Leeuw, P. W., Kroon, A. A., & Van Oostenbrugge, R. J. (2016). Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension. American Journal of Hypertension, 29(4), 464-469. https://doi.org/10.1093/ajh/hpv122
    • Mihl, C., Kok, M., Altintas, S., Kietselaer, B. L. J. H., Turek, J., Wildberger, J. E., & Das, M. (2016). Evaluation of individually body weight adapted contrast media injection in coronary CT-angiography. European Journal of Radiology, 85(4), 830-836. https://doi.org/10.1016/j.ejrad.2015.12.031
    • Kok, M., de Haan, M., Mihl, C., Eijsvoogel, N. G., Hendriks, B. M. F., Sailer, A. M., Derks, K., Schnerr, R. S., Schurink, G., Wildberger, J. E., & Das, M. (2016). Individualized CT Angiography Protocols for the Evaluation of the Aorta: A Feasibility Study. Journal of Vascular and Interventional Radiology, 27(4), 531-538. https://doi.org/10.1016/j.jvir.2016.01.009
    • Mahl, C., Egea, V., Megens, R. T. A., Pitsch, T., Santovito, D., Weber, C., & Ries, C. (2016). RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/beta-catenin signaling in human mesenchymal stem cells. Cellular and Molecular Life Sciences, 73(7), 1489-1501. https://doi.org/10.1007/s00018-015-2054-4
    • Broen, M. P. G., Marsman, V. A. M., Kuijf, M. L., Van Oostenbrugge, R. J., van Os, J., & Leentjens, A. F. G. (2016). Unraveling the Relationship between Motor Symptoms, Affective States and Contextual Factors in Parkinson's Disease: A Feasibility Study of the Experience Sampling Method. PLOS ONE, 11(3), Article e0151195. https://doi.org/10.1371/journal.pone.0151195
    • van Overbeek, E. C., Staals, J., Knottnerus, I. L. H., ten Cate, H., & van Oostenbrugge, R. J. (2016). Plasma tPA-Activity and Progression of Cerebral White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 11(3), Article e0150740. https://doi.org/10.1371/journal.pone.0150740
    • van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., Wildberger, J. E., & Jansen, J. F. A. (2016). Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements. Journal of Neuroendocrinology, 28(3), Article 12366. https://doi.org/10.1111/jne.12366
    • Berkhemer, O. A., Jansen, I. G. H., Beumer, D., Fransen, P. S. S., van den Berg, L. A., Yoo, A. J., Lingsma, H. F., Sprengers, M. E. S., Jenniskens, S. F. M., Lycklama a Nijeholt, G. J., van Walderveen, M. A. A., van den Berg, R., Bot, J. C. J., Beenen, L. F. M., Boers, A. M. M., Slump, C. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Dippel, D. W. J., ... Majoie, C. B. L. M. (2016). Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke. Stroke, 47(3), 768-776. https://doi.org/10.1161/STROKEAHA.115.011788
    • Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163. https://doi.org/10.1016/j.molmet.2015.12.005
    • Gerdes, N., Seijkens, T., Lievens, D., Kuijpers, M. J. E., Winkels, H., Projahn, D., Hartwig, H., Beckers, L., Megens, R. T. A., Boon, L., Noelle, R. J., Soehnlein, O., Heemskerk, J. W. M., Weber, C., & Lutgens, E. (2016). Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes. Arteriosclerosis Thrombosis and Vascular Biology, 36(3), 482-490. https://doi.org/10.1161/ATVBAHA.115.307074
    • de Bruin, R. G., Shiue, L., Prins, J., de Boer, H. C., Singh, A., Fagg, W. S., van Gils, J. M., Duijs, J. M. G. J., Katzman, S., Kraaijeveld, A. O., Bohringer, S., Leung, W. Y., Kielbasa, S. M., Donahue, J. P., van der Zande, P. H. J., Sijbom, R., van Alem, C. M. A., Bot, I., van Kooten, C., ... van der Veer, E. P. (2016). Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. Nature Communications, 7, Article 10846. https://doi.org/10.1038/ncomms10846
    • Santos, E. M. M., Marquering, H. A., den Blanken, M. D., Berkhemer, O. A., Boers, A. M. M., Yoo, A. J., Beenen, L. F., Treurniet, K. M., Wismans, C., van Noort, K., Lingsma, H. F., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Niessen, W. J., & Majoie, C. B. (2016). Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke. Stroke, 47(3), 732-741. https://doi.org/10.1161/STROKEAHA.115.011187
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2016). Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis. Age, 38(1), Article 17. https://doi.org/10.1007/s11357-016-9878-1
    • Hartmann, P., Zhou, Z., Natarelli, L., Wei, Y., Nazari-Jahantigh, M., Zhu, M., Grommes, J., Steffens, S., Weber, C., & Schober, A. (2016). Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nature Communications, 7, Article 10521. https://doi.org/10.1038/ncomms10521
    • van Elmpt, W., Zegers, K., Reymen, B., Even, A. J. G., Dingemans, A.-M. C., Öllers, M., Wildberger, J. E., Mottaghy, F. M., Das, M., Troost, E. G. C., & Lambin, P. (2016). Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion. European Journal of Nuclear Medicine and Molecular Imaging, 43(2), 240-248. https://doi.org/10.1007/s00259-015-3169-4
    • MR CLEAN Investigators, van Zwam, W., & van Oostenbrugge, R. J. (2016). Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke. Neuroradiology, 58(2), 133-139. https://doi.org/10.1007/s00234-015-1607-4
    • Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012
    • Steinbuch, J., Hoeks, A. P. G., Hermeling, E., Truijman, M. T. B., Schreuder, F. H. B. M., & Mess, W. (2016). Standard B-Mode Ultrasound Measures Local Carotid Artery Characteristics as Reliably as Radiofrequency Phase Tracking in Symptomatic Carotid Artery Patients. Ultrasound in Medicine and Biology, 42(2), 586-595. https://doi.org/10.1016/j.ultrasmedbio.2015.07.030
    • Marsch, E., Theelen, T., Janssen, B. J., Briedé, J. J., Haenen, G. R., Senden, J., van Loon, L. J., Poeze - van Bokhoven, M., Bierau, J., Gijbels, M. J., Daemen, M. J., & Sluimer, J. (2016). The effect of prolonged dietary nitrate supplementation on atherosclerosis development. Atherosclerosis, 245, 212-221. https://doi.org/10.1016/j.atherosclerosis.2015.11.031
    • Fransen, P. S. S., Berkhemer, O. A., Lingsma, H. F., Beumer, D., van den Berg, L. A., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2016). Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke A Randomized Clinical Trial. JAMA Neurology, 73(2), 190-196. https://doi.org/10.1001/jamaneurol.2015.3886
    • MR CLEAN Investigators, van Oostenbrugge, R. J., & van Zwam, W. (2016). Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke. PLOS ONE, 11(1), Article e0145641. https://doi.org/10.1371/journal.pone.0145641
    • Schrauwen-Hinderling, V. B., Kooi, E., & Schrauwen, P. (2016). Mitochondrial Function and Diabetes: Consequences for Skeletal and Cardiac Muscle Metabolism. Antioxidants & Redox Signaling, 24(1), 39-51. https://doi.org/10.1089/ars.2015.6291
    • Rost, N. S., Bottle, A., Lee, J. M., Randall, M., Middleton, S., Shaw, L., Thijs, V., Rinkel, G. J. E., Hemmen, T. M., Global Comparators Stroke GOAL collaborators, Eleopra, R., van Oostenbrugge, R. J., Fenwick, C., Pelly, M., Vaux, E., van Wyk, A., Spencer, M., Peggy, G., Matzkiw, H., & Newman, J. (2016). Stroke severity is a crucial predictor of outcome: An international prospective validation study. Journal of the American Heart Association, 5(1), 1-7. https://doi.org/10.1161/JAHA.115.002433