• 2016
    • Luiken, J. J. F. P., Chanda, D., Nabben, M., Neumann, D., & Glatz, J. F. C. (2016). Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1862(12), 2253-2258. https://doi.org/10.1016/j.bbadis.2016.09.004
    • Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Gijbels, M. J. J., Li, J., Hendrikx, T., Oligschläger, Y., van Gorp, P. J., Binder, C. J., Donners, M. M. P. C., & Shiri-Sverdlov, R. (2016). Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice. Atherosclerosis, 255, 59-65. https://doi.org/10.1016/j.atherosclerosis.2016.10.038
    • van den Berg, L. A., Dijkgraaf, M. G. W., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., Lingsma, H., Majoie, C. B. M., Dippel, D. W. J., van der Lugt, A. J., van Oostenbrugge, R. J., van Zwam, W. H., & Roos, Y. B. W. E. M. (2016). Two-year clinical follow-up of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN): design and statistical analysis plan of the extended follow-up study. Trials, 17(1), Article 555. https://doi.org/10.1186/s13063-016-1669-6
    • Agten, S. M., Koenen, R. R., Ippel, H., Eckardt, V., von Hundelshausen, P., Mayo, K. H., Weber, C., & Hackeng, T. M. (2016). Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation. Angewandte Chemie-International Edition, 55(48), 14963-14966. https://doi.org/10.1002/anie.201607036
    • Al-bataineh, M. M., Li, H., Ohmi, K., Gong, F., Marciszyn, A. L., Naveed, S., Zhu, X., Neumann, D., Wu, Q., Cheng, L., Fenton, R. A., Pastor-Soler, N. M., & Hallows, K. R. (2016). Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. American Journal of Physiology-Renal Physiology, 311(5), F890-F900. https://doi.org/10.1152/ajprenal.00308.2016
    • Daemen, M. J. A. P., Ferguson, M. S., Gijsen, F. J. H., Hippe, D. S., Kooi, M. E., Demarco, K., van der Wal, A. C., Yuan, C., & Hatsukami, T. S. (2016). Carotid plaque fissure: An underestimated source of intraplaque hemorrhage. Atherosclerosis, 254, 102-108. https://doi.org/10.1016/j.atherosclerosis.2016.09.069
    • Poort, L. J., Kiewiet, C. C., Cleutjens, J. P. M., Houben, R., Hoebers, F. J. P., & Kessler, P. A. W. H. (2016). Osseointegration and implant stability of extraoral implants in Gottingen minipigs after irradiation. Journal of Cranio-Maxillofacial Surgery, 44(11), 1842-1848. https://doi.org/10.1016/j.jcms.2016.08.019
    • Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Mueller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., Fischer, K., Lutter, D., Sanchez-Garrido, M. A., Liu, P., Tuckermann, J., Malehmir, M., Healy, M. E., Weber, A., Heikenwalder, M., ... Mueller, T. D. (2016). Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell, 167(3), 843-857. https://doi.org/10.1016/j.cell.2016.09.014
    • Ortega-Gomez, A., Salvermoser, M., Rossaint, J., Pick, R., Brauner, J., Lemnitzer, P., Tilgner, J., de Jong, R. J., Megens, R. T. A., Jamasbi, J., Doering, Y., Pham, C. T., Scheiermann, C., Siess, W., Drechsler, M., Weber, C., Grommes, J., Zarbock, A., Walzog, B., & Soehnlein, O. (2016). Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. Circulation, 134(16), 1176-1188. https://doi.org/10.1161/CIRCULATIONAHA.116.024790
    • Marsch, E., Demandt, J. A. F., Theelen, T. L., Tullemans, B. M. E., Wouters, K., Boon, M. R., van Dijk, T. H., Gijbels, M. J., Dubois, L. J., Meex, S. J. R., Mazzone, M., Hung, G., Fisher, E. A., Biessen, E. A. L., Daemen, M. J. A. P., Rensen, P. C. N., Carmeliet, P., Groen, A. K., & Sluimer, J. C. (2016). Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. European Heart Journal, 37(39), 2993-2997. https://doi.org/10.1093/eurheartj/ehw156
    • Dippel, D. W., Majoie, C. B., Roos, Y. B., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Lingsma, H. F., Koudstaal, P. J., Treurniet, K. M., van den Berg, L. A., Beumer, D., Fransen, P. S., & Berkhemer, O. A. (2016). Influence of Device Choice on the Effect of Intra-Arterial Treatment for Acute Ischemic Stroke in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Stroke, 47(10), 2574-2581. https://doi.org/10.1161/STROKEAHA.116.013929
    • van der Vleuten, C., & Heeneman, S. (2016). On the issue of costs in programmatic assessment. Perspectives on Medical Education, 5(5), 303–307. Article 303. https://doi.org/10.1007/s40037-016-0295-z
    • Li, J., Chanda, D., van Gorp, P., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Debets, J., Oligschläger, Y., Gijbels, M. J. J., Neumann, D., & Shiri-Sverdlov, R. (2016). Macrophage Stimulating Protein Enhances Hepatic Inflammation in alpha NASH Model. PLOS ONE, 11(9), Article e0163843. https://doi.org/10.1371/journal.pone.0163843
    • Saver, J. L., Goyal, M., van der Lugt, A., Menon, B. K., Majoie, C. B. L. M., Dippel, D. W., Campbell, B. C., Nogueira, R. G., Demchuk, A. M., Tomasello, A., Cardona, P., Devlin, T. G., Frei, D. F., de Rochemont, R. D. M., Berkhemer, O. A., Jovin, T. G., Siddiqui, A. H., van Zwam, W. H., Davis, S. M., ... Hill, M. D. (2016). Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA-Journal of the American Medical Association, 316(12), 1279-1288. https://doi.org/10.1001/jama.2016.13647
    • Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C.-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G.-P., Biessen, E. A. L., & Heeneman, S. (2016). Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice. PLOS ONE, 11(9), Article e0162595. https://doi.org/10.1371/journal.pone.0162595
    • Stöger, L., Boshuizen, M. C. S., Brufau, G., Gijbels, M. J. J., Wolfe, I. M. J., van der Velden, S., Pottgens, C. C. H., Vergouwe, M. N., Wijnands, E., Beckers, L., Goossens, P., Kerksiek, A., Havinga, R., Muller, W., Luetjohann, D., Groen, A. K., & de Winther, M. P. J. (2016). Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes. Thrombosis and Haemostasis, 116(3), 565-577. https://doi.org/10.1160/TH16-01-0043
    • Field, T. S., Doubal, F. N., Johnson, W., Backhouse, E., McHutchison, C., Cox, S., Corley, J., Pattie, A., Gow, A. J., Shenkin, S., Cvoro, V., Morris, Z., Staals, J., Bastin, M., Deary, I. J., & Wardlaw, J. M. (2016). Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936. Aging, 8(9), 2039-2061. https://doi.org/10.18632/aging.101043
    • van Bussel, F. C. G., Backes, W. H., Hofman, P. A. M., Puts, N. A. J., Edden, R. A. E., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., Wildberger, J. E., & Jansen, J. (2016). Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning. Medicine, 95(36), Article e4803. https://doi.org/10.1097/MD.0000000000004803
    • Chanda, D., Li, J., Oligschläger, Y., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Shiri-Sverdlov, R., & Neumann, D. (2016). MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Experimental and Molecular Medicine, 48(9), Article e258. https://doi.org/10.1038/emm.2016.79
    • Daeichin, V., Kooiman, K., Skachkov, I., Bosch, J. G., Theelen, T. L., Steiger, K., Needles, A., Janssen, B. J., Daemen, M. J. A. P., van der Steen, A. F. W., de Jong, N., & Sluimer, J. C. (2016). QUANTIFICATION OF ENDOTHELIAL alpha(V)beta(3) EXPRESSION WITH HIGH-FREQUENCY ULTRASOUND AND TARGETED MICROBUBBLES: IN VITRO AND IN VIVO STUDIES. Ultrasound in Medicine and Biology, 42(9), 2283-2293. https://doi.org/10.1016/j.ultrasmedbio.2016.05.005
    • Al-Ali, F., Berkhemer, O. A., Yousman, W. P., Elias, J. J., Bender, E. N., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Dillon, W. P., & Majoie, C. B. L. M. (2016). The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial. Stroke, 47(9), 2286-2291. https://doi.org/10.1161/STROKEAHA.116.013513
    • Gamrekelashvili, J., Giagnorio, R., Jussofie, J., Soehnlein, O., Duchene, J., Briseno, C. G., Ramasamy, S. K., Krishnasamy, K., Limbourg, A., Kapanadze, T., Ishifune, C., Hinkel, R., Radtke, F., Strobl, L. J., Zimber-Strobl, U., Napp, L. C., Bauersachs, J., Haller, H., Yasutomo, K., ... Limbourg, F. P. (2016). Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nature Communications, 7, Article 12597. https://doi.org/10.1038/ncomms12597
    • Lindeboom, L., de Graaf, R. A., Nabuurs, C. I., van Ewijk, E., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016). Quantum coherence spectroscopy to measure dietary fat retention in the liver. JCI INSIGHT, 1(13), Article e84671. https://doi.org/10.1172/jci.insight.84671
    • Berkhemer, O. A., van den Berg, L. A., Fransen, P. S. S., Beumer, D., Yoo, A. J., Lingsma, H. F., Schonewille, W. J., van den Berg, R., Wermer, M. J. H., Boiten, J., Nijeholt, G. J. L., Nederkoorn, P. J., Hollmann, M. W., van Zwam, W. H., van der Lugt, A., van Oostenbrugge, R. J., Majoie, C. B. L. M., Dippel, D. W. J., & Roos, Y. B. W. E. M. (2016). The effect of anesthetic management during intra-arterial therapy for acute stroke in MR CLEAN. Neurology, 87(7), 656-664. https://doi.org/10.1212/WNL.0000000000002976
    • Zhu, X., Dahlmans, V., Thali, R., Preisinger, C., Viollet, B., Voncken, J. W., & Neumann, D. (2016). AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E. Journal of Biological Chemistry, 291(33), 17020-17027. https://doi.org/10.1074/jbc.C116.740498
    • van Overbeek, E. C., Staals, J., & van Oostenbrugge, R. J. (2016). Decreased kidney function relates to progression of cerebral microbleeds in lacunar stroke patients. International journal of stroke, 11(6), 695-700. https://doi.org/10.1177/1747493016641966
    • van Bussel, F. C. G., Backes, W. H., van Veenendaal, T. M., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Sep, S. J. S., Dagnelie, P. C., Schaper, N., Stehouwer, C. D. A., Wildberger, J. E., & Jansen, J. (2016). Functional brain networks are altered in type 2 diabetes and pre-diabetes signs for compensation of cognitive decrements? - The Maastricht Study: signs for compensation of cognitive decrements? - The Maastricht Study. Diabetes, 65(8), 2404-2413. https://doi.org/10.2337/db16-0128
    • Holtackers, R. J., Spronck, B., Heusinkveld, M. H. G., Crombag, G., op het Roodt, J., Delhaas, T., Kooi, E., Reesink, K. D., & Hermeling, E. (2016). Head orientation should be considered in ultrasound studies on carotid artery distensibility. Journal of Hypertension, 34(8), 1551-1555. https://doi.org/10.1097/HJH.0000000000000985
    • Kok, M., Turek, J., Mihl, C., Reinartz, S. D., Gohmann, R. F., Nijssen, E. C., Kats, S., van Ommen, V. G. V. A., Kietselaer, B. L. J. H., Wildberger, J. E., & Das, M. (2016). Low contrast media volume in pre-TAVI CT examinations. European Radiology, 26(8), 2426-2435. https://doi.org/10.1007/s00330-015-4080-x
    • De Guio, F., Jouvent, E., Biessels, G. J., Black, S. E., Brayne, C., Chen, C., Cordonnier, C., De Leeuw, F.-E., Dichgans, M., Doubal, F., Duering, M., Dufouil, C., Duzel, E., Fazekas, F., Hachinski, V., Ikram, M. A., Linn, J., Matthews, P. M., Mazoyer, B., ... Chabriat, H. (2016). Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 36(8), 1319-1337. https://doi.org/10.1177/0271678X16647396
    • Schloss, M. J., Horckmans, M., Nitz, K., Duchene, J., Drechsler, M., Bidzhekov, K., Scheiermann, C., Weber, C., Soehnlein, O., & Steffens, S. (2016). The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Molecular Medicine, 8(8), 937-948. https://doi.org/10.15252/emmm.201506083
    • Mulder, M. J. H. L., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., & Dippel, D. W. J. (2016). Treatment in patients who are not eligible for intravenous alteplase: MR CLEAN subgroup analysis. International journal of stroke, 11(6), 637-645. https://doi.org/10.1177/1747493016641969
    • Klinkenberg, L. J. J., Luyten, P., van der Linden, N., Urgel, K., Snijders, D. P. C., Knackstedt, C., Dennert, R., Kietselaer, B. L. J. H., Mingels, A., Cardinaels, E. P. M., Peeters, F. E. C. M., van Suijlen, J. D. E., ten Kate, J., Marsch, E., Theelen, T. L., Sluimer, J. C., Wouters, K., Bekers, O., Bekkers, B., ... Meex, S. J. R. (2016). Cardiac Troponin T and I Release After a 30-km Run. American Journal of Cardiology, 118(2), 281-287. https://doi.org/10.1016/j.amjcard.2016.04.030
    • Smulders, M. W., Kietselaer, B. L. J. H., Schalla, S., Bucerius, J., Jaarsma, C., van Dieijen-Visser, M. P., Mingels, A. M. A., Brunner-La Rocca, H., Post, M., Das, M., Crijns, H. J. G. M., Wildberger, J. E., & Bekkers, B. (2016). Acute chest pain in the high-sensitivity cardiac troponin era: A changing role for noninvasive imaging?American Heart Journal, 177, 102-111. https://doi.org/10.1016/j.ahj.2016.03.025
    • Wilde, B., Mertens, A., Arends, S. J., Rouhl, R. P., Bijleveld, R., Huitema, J., Timmermans, S. A., Damoiseaux, J., Witzke, O., Duijvestijn, A. M., van Paassen, P., van Oostenbrugge, R. J., & Tervaert, J. W. C. (2016). Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls. Arthritis Research & Therapy, 18(1), Article 147. https://doi.org/10.1186/s13075-016-1044-8
    • Skarpengland, T., Holm, S., Scheffler, K., Gregersen, I., Dahl, T. B., Suganthan, R., Segers, F. M., Ostlie, I., Otten, J. J. T., Luna, L., Ketelhuth, D. F. J., Lundberg, A. M., Neurauter, C. G., Hildrestrand, G., Skjelland, M., Bjorndal, B., Svardal, A. M., Iversen, P. O., Hedin, U., ... Aukrust, P. (2016). Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports, 6, Article 28337. https://doi.org/10.1038/srep28337
    • Das, M., & Wildberger, J. E. (2016). Diagnostik der akuten Lungenembolie. Der Radiologe, 56(6), 543-554. https://doi.org/10.1007/s00117-016-0100-3
    • van Hoof, R. H. M., Heeneman, S., Wildberger, J. E., & Kooi, E. (2016). Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature. Current Atherosclerosis Reports, 18(6), Article 33. https://doi.org/10.1007/s11883-016-0583-4
    • Yoo, A. J., Berkhemer, O. A., Fransen, P. S. S., van den Berg, L. A., Beumer, D., Lingsma, H. F., Schonewille, W. J., Sprengers, M. E. S., van den Berg, R., van Walderveen, M. A. A., Beenen, L. F. M., Wermer, M. J. H., Nijeholt, G. J. L. A., Boiten, J., Jenniskens, S. F. M., Bot, J. C. J., Boers, A. M. M., Marquering, H. A., Roos, Y. B. W. E. M., ... Majoie, C. B. L. M. (2016). Effect of baseline Alberta Stroke Program Early CT Score on safety and efficacy of intra-arterial treatment: a subgroup analysis of a randomised phase 3 trial (MR CLEAN). Lancet Neurology, 15(7), 685-694. https://doi.org/10.1016/S1474-4422(16)00124-1
    • Nabben, M., & Neumann, D. (2016). GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?Cardiovascular Drugs and Therapy, 30(3), 233-235. https://doi.org/10.1007/s10557-016-6669-y
    • Kok, M., Mihl, C., Hendriks, B. M. F., Altintas, S., Kietselaer, B. L. J. H., Wildberger, J. E., & Das, M. (2016). Optimizing contrast media application in coronary CT angiography at lower tube voltage: Evaluation in a circulation phantom and sixty patients. European Journal of Radiology, 85(6), 1068-1074. https://doi.org/10.1016/j.ejrad.2016.03.022
    • Post, M. C., Van Dijk, A. P., Hoendermis, E. S., Bogaard, H. J., Van Empel, V., & Boomars, K. A. (2016). PulmoCor: national registry for pulmonary hypertension. Netherlands Heart Journal, 24(6), 425-426. https://doi.org/10.1007/s12471-016-0830-x
    • Klooster, D. C. W., de Louw, A. J. A., Aldenkamp, A. P., Besseling, R. M. H., Mestrom, R. M. C., Carrette, S., Zinger, S., Bergmans, J. W. M., Mess, W. H., Vonck, K., Carrette, E., Breuer, L. E. M., Bernas, A., Tijhuis, A. G., & Boon, P. (2016). Technical aspects of neurostimulation: Focus on equipment, electric field modeling, and stimulation protocols. Neuroscience and Biobehavioral Reviews, 65, 113-141. https://doi.org/10.1016/j.neubiorev.2016.02.016
    • Crijnen, Y. S., Nouwens, F., de Lau, L. M. L., Visch-Brink, E. G., van de Sandt-Koenderman, M. W. M. E., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Roos, Y. B. W. E. M., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., & Dippel, D. W. J. (2016). Early effect of intra-arterial treatment in ischemic stroke on aphasia recovery in MR CLEAN. Neurology, 86(22), 2049-2055. https://doi.org/10.1212/WNL.0000000000002724
    • Simsekyilmaz, S., Liehn, E. A., Weinandy, S., Schreiber, F., Megens, R. T. A., Theelen, W., Smeets, R., Jockenhoevel, S., Gries, T., Moeller, M., Klee, D., Weber, C., & Zernecke, A. (2016). Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice. PLOS ONE, 11(5), Article e0155829. https://doi.org/10.1371/journal.pone.0155829
    • Bouwmans, A. E. P., Weber, W. E. J., Leentjens, A. F. G., & Mess, W. H. (2016). Transcranial sonography findings related to depression in parkinsonian disorders: cross-sectional study in 126 patients. PEERJ, 4(5), Article e2037. https://doi.org/10.7717/peerj.2037
    • Beumer, D., Rozeman, A. D., Nijeholt, G. J. L. A., Brouwer, P. A., Jenniskens, S. F. M., Algra, A., Boiten, J., Schonewille, W., van Oostenbrugge, R. J., Dippel, D. W. J., & van Zwam, W. H. (2016). The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study. BMC Neurology, 16(1), Article 68. https://doi.org/10.1186/s12883-016-0592-5
    • Wichapong, K., Alard, J. .-E., Ortega-Gomez, A., Weber, C., Hackeng, T. M., Soehnlein, O., & Nicolaes, G. A. F. (2016). Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). Journal of Medicinal Chemistry, 59(9), 4289-4301. https://doi.org/10.1021/acs.jmedchem.5b01952
    • Douven, E., Schievink, S. H. J., Verhey, F. R. J., van Oostenbrugge, R. J., Aalten, P., Staals, J., & Köhler, S. (2016). The Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design. BMC Neurology, 16(1), Article 65. https://doi.org/10.1186/s12883-016-0588-1
    • Koppen, H., Palm-Meinders, I. H., Mess, W. H., Keunen, R. W., Terwindt, G. M., Launer, L. J., van Buchem, M. A., Kruit, M. C., & Ferrari, M. D. (2016). Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity. Neurology, 86(18), 1668-1675. https://doi.org/10.1212/WNL.0000000000002538