Wim van Zwam

Professor

Education/Training
• Medical study, MD (Free University, Amsterdam) 1989
• Tropical Medicine (Dutch Tropical Institute, Amsterdam) 1992
• Radiology (Maastricht University Medical Centre) 2002
• International Diplome in Neurovascular Diseases, MSc (Université Paris XI) 2004
 
Positions and Employment
• Resident Tropical Medicine (Surgery – Gynaecology) 1989 – 1992
Slotervaart General Hospital, Amsterdam
• Tropical Doctor, Medecins Sans Frontieres 1992 – 1994
Somalië, Laos, Sri Lanka
• Resident Radiology, MUMC+, Maastricht 1995 – 2002
• Interventional Radiology, Leuven, Belgium 2002
• Neuro-interventional Radiology, Tilburg 2002
• Neuro-interventional Radiology, Essen, Germany 2003
• Interventional Radiology, MUMC+, Maastricht 2003
 
Thesis, PhD: 2013
Aneurysmal subarachnoid hemorrhage: Imaging strategies and cost-effectiveness aspects in diagnostic work-up and post-therapeutic follow-up.
 
• PI of MACCA study (Magnetic resonance Angiography with Contrast in patients with Cerebra Aneurysms). Funding: 300k Euro from Profileringsfonds azM. 2006-2010 
• Co-PI, member of executive committee and imaging committee of the MRCLEAN trial (Multicenter Randomized Clinical trial of Endovascular treatment of Acute ischemic stroke in the Netherlands). 2010 - 2015
Funding: 800k Euro from Dutch Heart Foundaton; 500k Euro from unrestricted grants. 
 
Professional memberships: NVvR, NGIR, NNG, NVF, ESR, CIRSE, ESMINT, WFITN
Chair of Stroke Task Force, CIRSE
Board member of ESMINT
Member executive committee European Board of NeuroInterventions (EBNI)

PI of MRCLEAN_Late (MRCLEAN - patients arriving between 6 – 24 hrs after symptom onset), study under CONTRAST umbrella.
Co-PI, member of executive committee and imaging committee of CONTRAST (COnsortium for New Treatments in Acute Stroke).
Funding: 4000k Euro from Dutch Heart Foundaton; 4000k Euro from unrestricted grants. 200k Euro from Dutch Brain Council. 272k Euro from ZonMW
Member of executive committee MRCLEAN NoIV.

Department of Radiology and Nuclear Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 387 69 09

  • 2019
    • Compagne, K. C. J., Boers, A. M. M., Marquering, H. A., Berkhemer, O. A., Yoo, A. J., Beenen, L. F. M., van Oostenbrugge, R. J., van Zwam, W. H., Roos, Y. B. W. E. M., Majoie, C. B., van Es, A. C. G. M., van der Lugt, A., Dippel, D. W. J., Lingsma, H., & MR CLEAN Investigators (2019). Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke. European Radiology, 29(2), 736-744. https://doi.org/10.1007/s00330-018-5578-9
    • Boers, A. M. M., Jansen, I. G. H., Brown, S., Lingsma, H. F., Beenen, L. F. M., Devlin, T. G., San Roman, L., Heo, J.-H., Ribo, M., Almekhlafi, M. A., Liebeskind, D. S., Teitelbaum, J., Cuadras, P., de Rochemont, R. D. M., Beaumont, M., Brown, M. M., Yoo, A. J., Donnan, G. A., Mas, J. L., ... Majoie, C. B. L. M. (2019). Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke. JAMA Neurology, 76(2), 194-202. https://doi.org/10.1001/jamaneurol.2018.3661
    • Sacks, D., van Overhagen, H., van Zwam, W. H., Radvany, M. G., Marx, M. V., Morgan, R. A., Vrazas, J. I., & Goh, G. S. (2019). The Role of Interventional Radiologists in Acute lschemic Stroke Interventions: A Joint Position Statement from the Society of Interventional Radiology, the Cardiovascular and Interventional Radiology Society of Europe, and the Interventional Radiology Society of Australasia. Journal of Vascular and Interventional Radiology, 30(2), 131-133. https://doi.org/10.1016/j.jvir.2018.09.035
    • Campbell, B. C. V., Majoie, C. B. L. M., Albers, G. W., Menon, B. K., Yassi, N., Sharma, G., van Zwam, W. H., van Oostenbrugge, R. J., Demchuk, A. M., Guillemin, F., White, P., Davalos, A., van der Lugt, A., Butcher, K. S., Cherifi, A., Marquering, H. A., Cloud, G., Macho Fernandez, J. M., Madigan, J., ... HERMES Collaboration (2019). Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurology, 18(1), 46-55. https://doi.org/10.1016/S1474-4422(18)30314-4
    • Goyal, M., Almekhlafi, M. A., Cognard, C., McTaggart, R., Blackham, K., Biondi, A., van der Lugt, A., Majoie, C. B. L. M., van Zwam, W. H., van der Worp, H. B., & Hill, M. D. (2019). Which patients with acute stroke due to proximal occlusion should not be treated with endovascular thrombectomy?Neuroradiology, 61(1), 3-8. https://doi.org/10.1007/s00234-018-2117-y
    • Pirson, F. A. V., Hinsenveld, W. H., Staals, J., de Greef, B. T. A., van Zwam, W. H., Dippel, D. W. J., Vos, J. A., Schonewille, W. J., van Oostenbrugge, R. J., & MR CLEAN Investigators (2019). The Effect of Body Mass Index on Outcome after Endovascular Treatment in Acute Ischemic Stroke Patients: A Post Hoc Analysis of the MR CLEAN Trial. Cerebrovascular Diseases, 48(3-6), 200-206. https://doi.org/10.1159/000504744
  • 2018
    • Boers, A. M. M., Jansen, I. G. H., Beenen, L. F. M., Devlin, T. G., San Roman, L., Heo, J. H., Ribo, M., Brown, S., Almekhlafi, M. A., Liebeskind, D. S., Teitelbaum, J., Lingsma, H. F., van Zwam, W. H., Cuadras, P., de Rochemont, R. D. M., Beaumont, M., Brown, M. M., Yoo, A. J., van Oostenbrugge, R. J., ... Majoie, C. B. L. M. (2018). Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. Journal of Neurointerventional Surgery, 10(12), 1137-1142. https://doi.org/10.1136/neurintsurg-2017-013724
    • Compagne, K. C. J., Clephas, P. R. D., Majoie, C. B. L. M., Roos, Y. B. W. E. M., Berkhemer, O. A., van Oostenbrugge, R. J., van Zwam, W. H., van Es, A. C. G. M., Dippel, D. W. J., van der Lugt, A., Bos, D., Beumer, D., Staals, J., & MR CLEAN Investigators (2018). Intracranial Carotid Artery Calcification and Effect of Endovascular Stroke Treatment: MR CLEAN Subgroup Analysis. Stroke, 49(12), 2961-2968. https://doi.org/10.1161/STROKEAHA.118.022400
    • Ernst, M., Boers, A. M. M., Forkert, N. D., Berkhemer, O. A., Roos, Y. B., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Vettorazzi, E., Fiehler, J., Marquering, H. A., Majoie, C. B. L. M., Gellissen, S., & MR CLEAN Trial Investigators (2018). Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach. American Journal of Neuroradiology, 39(11), 1989-1994. https://doi.org/10.3174/ajnr.A5821
    • van Overhagen, H., van Zwam, W. H., Krajina, A., Fiehler, J., Reekers, J. A., Cekirge, S., Thornton, J., Binkert, C. A., Brountzos, E., Gangi, A., & Morgan, R. (2018). CIRSE Position Statement: Interventional Radiologists and Intra-arterial Stroke Therapy. Cardiovascular and Interventional Radiology, 41(10), 1460-1462. https://doi.org/10.1007/s00270-018-2051-8
    • Roman, L. S., Menon, B. K., Blasco, J., Hernandez-Perez, M., Davalos, A., Majoie, C. B. L. M., Campbell, B. C. V., Guillemin, F., Lingsma, H., Anxionnat, R., Epstein, J., Saver, J. L., Marquering, H., Wong, J. H., Lopes, D., Reimann, G., Desal, H., Dippel, D. W. J., Coutts, S., ... HERMES Collaboration (2018). Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data. Lancet Neurology, 17(10), 895-904. https://doi.org/10.1016/S1474-4422(18)30242-4
    • Zhang, G., Treurniet, K. M., Jansen, I. G. H., Emmer, B. J., van den Berg, R., Marquering, H. A., Uyttenboogaart, M., Jenniskens, S. F. M., Roos, Y. B. W. E. M., van Doormaal, P. J., van Es, A. C. G. M., van der Lugt, A., Vos, J.-A., Nijeholt, G. J. L. A., van Zwam, W. H., Shi, H., Yoo, A. J., Dippel, D. W. J., Majoie, C. B. L. M., & MR CLEAN Registry Investigators (2018). Operator Versus Core Lab Adjudication of Reperfusion After Endovascular Treatment of Acute Ischemic Stroke. Stroke, 49(10), 2376-2382. https://doi.org/10.1161/STROKEAHA.118.022031
    • Goldhoorn, R.-J. B., Verhagen, M., Dippel, D. W. J., van der Lugt, A., Lingsma, H. F., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Vos, J. A., Boiten, J., van Zwam, W. H., van Oostenbrugge, R. J., van den Wijngaard, I., & MR CLEAN Registry Investigators (2018). Safety and Outcome of Endovascular Treatment in Prestroke-Dependent Patients Results From MR CLEAN Registry. Stroke, 49(10), 2406-2414. https://doi.org/10.1161/STROKEAHA.118.022352
    • Hoving, J. W., Marquering, H. A., Majoie, C. B. L. M., Yassi, N., Sharma, G., Liebeskind, D. S., van der Lugt, A., Roos, Y. B., van Zwam, W., van Oostenbrugge, R. J., Goyal, M., Saver, J. L., Jovin, T. G., Albers, G. W., Davalos, A., Hill, M. D., Demchuk, A. M., Bracard, S., Guillemin, F., ... Campbell, B. C. V. (2018). Volumetric and Spatial Accuracy of Computed Tomography Perfusion Estimated Ischemic Core Volume in Patients With Acute Ischemic Stroke. Stroke, 49(10), 2368-2375. https://doi.org/10.1161/STROKEAHA.118.020846
    • van Os, H. J. A., Ramos, L. A., Hilbert, A., van Leeuwen, M., van Walderveen, M. A. A., Kruyt, N. D., Dippel, D. W. J., Steyerberg, E. W., van der Schaaf, I. C., Lingsma, H. F., Schonewille, W. J., Majoie, C. B. L. M., Olabarriaga, S. D., Zwinderman, K. H., Venema, E., Marquering, H. A., Wermer, M. J. H., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., & van Zwam, W. (2018). Predicting Outcome of Endovascular Treatment for Acute Ischemic Stroke: Potential Value of Machine Learning Algorithms. Frontiers in Neurology, 9(SEP), Article 784. https://doi.org/10.3389/fneur.2018.00784
    • Mulder, M. J. H. L., Jansen, I. G. H., Goldhoorn, R.-J. B., Venema, E., Chalos, V., Compagne, K. C. J., Roozenbeek, B., Lingsma, H. F., Schonewille, W. J., van den Wijngaard, I. R., Boiten, J., Vos, J. A., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., & MR CLEAN Registry Investigators (2018). Time to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results. Circulation, 138(3), 232-240. https://doi.org/10.1161/CIRCULATIONAHA.117.032600
    • Autar, A. S. A., Hund, H. M., Ramlal, S. A., Hansen, D., Nijeholt, G. J. L. A., Emmer, B. J., de Maat, M. P. M., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M., van Beusekom, H. M. M., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Staals, J., Postma - Jacobi, L., van Oostenbrugge, R. J., & van Zwam, W. (2018). High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. Journal of the American Heart Association, 7(13), Article 008563. https://doi.org/10.1161/JAHA.118.008563
    • Boers, A. M. M., Sales Barros, R., Jansen, I. G. H., Berkhemer, O. A., Beenen, L. F. M., Menon, B. K., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Slump, C. H., Majoie, C. B. L. M., & Marquering, H. A. (2018). Value of Quantitative Collateral Scoring on CT Angiography in Patients with Acute Ischemic Stroke. American Journal of Neuroradiology, 39(6), 1074-1082. https://doi.org/10.3174/ajnr.A5623
    • Kappelhof, M., Marquering, H. A., Berkhemer, O. A., Borst, J., van der Lugt, A., van Zwam, W. H., Vos, J. A., Nijeholt, G. L. A., Majoie, C. B. L. M., & Emmer, B. J. (2018). Accuracy of CT Angiography for Differentiating Pseudo-Occlusion from True Occlusion or High-Grade Stenosis of the Extracranial ICA in Acute Ischemic Stroke: A Retrospective MR CLEAN Substudy. American Journal of Neuroradiology, 39(5), 892-898. https://doi.org/10.3174/ajnr.A5601
    • Kimberly, W. T., Dutra, B. G., Boers, A. M. M., Alves, H. C. B. R., Berkhemer, O. A., van den Berg, L., Sheth, K. N., Roos, Y. B. W. E. M., van der Lugt, A., Beenen, L. F. M., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., Lingsma, H. F., Marquering, H., Majoie, C. B. L. M., & MR CLEAN Investigators (2018). Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke A Secondary Analysis of the MR CLEAN Trial. JAMA Neurology, 75(4), 453-461. https://doi.org/10.1001/jamaneurol.2017.5162
    • Dijkland, S. A., Voormolen, D. C., Venema, E., Roozenbeek, B., Polinder, S., Haagsma, J. A., Nieboer, D., Chalos, V., Yoo, A. J., Schreuders, J., van der Lugt, A., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Zwam, W. H., van Oostenbrugge, R. J., Steyerberg, E. W., Dippel, D. W. J., Lingsma, H. F., & MR CLEAN Investigators (2018). Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials A Simulation Study. Stroke, 49(4), 965-971. https://doi.org/10.1161/STROKEAHA.117.020194
    • Jansen, I. G. H., Mulder, M. J. H. L., Goldhoorn, R.-J. B., Emmer, B. J., van Es, A. C. G. M., Roozenbeek, B., Schonewille, W. J., van den Berg, R., Coutinho, J. M., Staals, J., Postma, A. A., Lycklama, G. J., Hofmeijer, J., Martens, J. M., den Hertog, H. M., Sturm, F. J. C., van der Worp, H. B., Lo, R. H., Heijboer, R. J. J., ... MR CLEAN Registry Investigators (2018). Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry). BMJ, 360, Article 949. https://doi.org/10.1136/bmj.k949
    • Jansen, I. G. H., van Vuuren, A. B., van Zwam, W. H., van den Wijngaard, I. R., Berkhemer, O. A., Lingsma, H. F., Slump, C. H., van Oostenbrugge, R. J., Treurniet, K. M., Dippel, D. W. J., van Walderveen, M. A. A., van der Lugt, A., Roos, Y. B. W. E. M., Marquering, H. A., Majoie, C. B. L. M., van den Berg, R., & MR CLEAN Trial Investigators (2018). Absence of Cortical Vein Opacification Is Associated with Lack of Intra-arterial Therapy Benefit in Stroke. Radiology, 286(2), 643-650. https://doi.org/10.1148/radiol.2017162445
    • Treurniet, K. M., Berkhemer, O. A., Immink, R. V., Lingsma, H. F., Ward-van der Stam, V. M. C., Hollmann, M. W., Vuyk, J., van Zwam, W. H., van der Lugt, A., van Oostenbrugge, R. J., Dippel, D. W. J., Coutinho, J. M., Roos, Y. B. W. E. M., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Investigators (2018). A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia. Journal of Neurointerventional Surgery, 10(2), 107-111. https://doi.org/10.1136/neurintsurg-2017-012988
    • Alves, H. C., Treurniet, K. M., Dutra, B. G., Jansen, I. G. H., Boers, A. M. M., Santos, E. M. M., Berkhemer, O. A., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., van Oostenbrugge, R. J., Lingsma, H. F., Roos, Y. B. W. E. M., Yoo, A. J., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Trial Investigators (2018). Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke. Stroke, 49(2), 391-396. https://doi.org/10.1161/STROKEAHA.117.019509
    • Campbell, B. C. V., van Zwam, W. H., Goyal, M., Menon, B. K., Dippel, D. W. J., Demchuk, A. M., Bracard, S., White, P., Davalos, A., Majoie, C. B. L. M., van der Lugt, A., Ford, G. A., de la Ossa, N., Kelly, M., Bourcier, R., Donnan, G. A., Roos, Y. B. W. E. M., Bang, O. Y., Nogueira, R. G., ... HERMES Collaboration (2018). Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data. Lancet Neurology, 17(1), 47-53. https://doi.org/10.1016/S1474-4422(17)30407-6
  • 2017
    • Boers, A. M. M., Jansen, I. G. H., Berkhemer, O. A., Yoo, A. J., Lingsma, H. F., Slump, C. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Trial Investigators (2017). Collateral status and tissue outcome after intra-arterial therapy for patients with acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 37(11), 3589-3598. https://doi.org/10.1177/0271678X16678874
    • Compagne, K. C. J., van Es, A. C. G. M., Berkhemer, O. A., Borst, J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., Marquering, H. A., Dippel, D. W. J., van der Lugt, A., Emmer, B. J., & MR CLEAN Trial Investigators (2017). Prevalence of Carotid Web in Patients with Acute Intracranial Stroke Due to Intracranial Large Vessel Occlusion. Radiology, 286(3), 1000-1007. https://doi.org/10.1148/radiol.2017170094
    • Heshmatollah, A., Fransen, P. S. S., Berkhemer, O. A., Beumer, D., van der Lugt, A., Majoie, C. B. L. M., Oostenbrugge, R. J., van Zwam, W. H., Koudstaal, P. J., Roos, Y. B. W. E. M., Dippel, D. W. J., & MR CLEAN Investigators (2017). Endovascular thrombectomy in patients with acute ischaemic stroke and atrial fibrillation: a MR CLEAN subgroup analysis. Eurointervention, 13(8), 996-1002. https://doi.org/10.4244/EIJ-D-16-00905
    • Schreuders, J., van den Berg, L. A., Fransen, P. S. S., Berkhemer, O. A., Beumer, D., Lingsma, H. F., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., de Kort, P. L. M., Roos, Y. B. W. E. M., Dippel, D. W. J., & MR CLEAN Investigators (2017). Quality of life after intra-arterial treatment for acute ischemic stroke in the MR CLEAN trialUpdate. International journal of stroke, 12(7), 708-712. https://doi.org/10.1177/1747493017706244
    • Ernst, M., Boers, A. M. M., Aigner, A., Berkhemer, O. A., Yoo, A. J., Roos, Y. B., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Fiehler, J., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Trial Investigators (2017). Association of Computed Tomography Ischemic Lesion Location With Functional Outcome in Acute Large Vessel Occlusion Ischemic Stroke. Stroke, 48(9), 2426-2433. https://doi.org/10.1161/STROKEAHA.117.017513
    • Borst, J., Berkhemer, O. A., Santos, E. M. M., Yoo, A. J., den Blanken, M., Roos, Y. B. W. E. M., van Bavel, E., van Zwam, W. H., van Oostenbrugge, R. J., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Investigators (2017). Value of Thrombus CT Characteristics in Patients with Acute Ischemic Stroke. American Journal of Neuroradiology, 38(9), 1758-1764. https://doi.org/10.3174/ajnr.A5331
    • Venema, E., Boodt, N., Berkhemer, O. A., Rood, P. P. M., van Zwam, W. H., van Oostenbrugge, R. J., van der Lugt, A., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Lingsma, H. F., Dippel, D. W. J., & MR CLEAN Investigators (2017). Workflow and factors associated with delay in the delivery of intra-arterial treatment for acute ischemic stroke in the MR CLEAN trial. Journal of Neurointerventional Surgery, 10(5), 424-U19. https://doi.org/10.1136/neurintsurg-2017-013198
    • Mulder, M. J. H. L., Ergezen, S., Lingsma, H. F., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Nijeholt, G. L. A., Emmer, B. J., van der Worp, H. B., Nederkoorn, P. J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., & Multicenter Randomized Clinical Tr (2017). Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands). Stroke, 48(7), 1869-1876. https://doi.org/10.1161/STROKEAHA.116.016225
    • Yoo, A. J., Khatri, P., Mocco, J., Zaidat, O. O., Gupta, R., Frei, D., Lopes, D., Shownkeen, H., Berkhemer, O. A., Meyer, D., Hak, S. S., Kuo, S. S., Buell, H., Bose, A., Sit, S. P., THERAPY Trial Investigators, van Zwam, W., & von Kummer, R. (2017). Impact of Thrombus Length on Outcomes After Intra-Arterial Aspiration Thrombectomy in the THERAPY Trial. Stroke, 48(7), 1895-1900. https://doi.org/10.1161/STROKEAHA.116.016253
    • Berkhemer, O. A., Borst, J., Kappelhof, M., Yoo, A. J., van den Berg, L. A., Fransen, P. S. S., Beumer, D., Schonewille, W. J., Nederkoorn, P. J., Wermer, M. J. H., Marquering, H. A., Lingsma, H. F., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Dippel, D. W. J., van Zwam, W. H., Majoie, C. B. L. M., Emmer, B. J., van der Lugt, A., & MR CLEAN Investigators (2017). Extracranial Carotid Disease and Effect of Intra-arterial Treatment in Patients With Proximal Anterior Circulation Stroke in MR CLEAN. Annals of Internal Medicine, 166(12), 867-875. https://doi.org/10.7326/M16-1536
    • Beumer, D., van Boxtel, T. H., Schipperen, S., van Zwam, W. H., Nijeholt, G. J. L. A., Brouwer, P. A., Jenniskens, S. F. M., Schonewille, W. J., Vos, J. A., van der Lugt, A., Roos, Y. B., Majoie, C. B., van Oostenbrugge, R. J., Dippel, D. W. J., & MR CLEAN Pretrial Investigators (2017). The relationship between interventionists' experience and clinical and radiological outcome in intra-arterial treatment for acute ischemic stroke. A MR CLEAN pretrial survey. Journal of the Neurological Sciences, 377, 97-101. https://doi.org/10.1016/j.jns.2017.04.002
    • Mulder, M. J. H. L., Berkhemer, O. A., Fransen, P. S. S., van den Berg, L. A., Lingsma, H. F., den Hertog, H. M., Staals, J., Jenniskens, S. F. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., & MR CLEAN Investigators (2017). Does prior antiplatelet treatment improve functional outcome after intra-arterial treatment for acute ischemic stroke?International journal of stroke, 12(4), 368-376. https://doi.org/10.1177/1747493016677842
    • Venema, E., Mulder, M. J. H. L., Roozenbeek, B., Broderick, J. P., Yeatts, S. D., Khatri, P., Berkhemer, O. A., Emmer, B. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., van Oostenbrugge, R. J., van Zwam, W. H., van der Lugt, A., Steyerberg, E. W., Dippel, D. W. J., & Lingsma, H. F. (2017). Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials. BMJ, 357, Article j1710. https://doi.org/10.1136/bmj.j1710
    • Osei, E., den Hertog, H. M., Berkhemer, O. A., Fransen, P. S. S., Roos, Y. B. W. E. M., Beumer, D., van Oostenbrugge, R. J., Schonewille, W. J., Boiten, J., Zandbergen, A. A. M., Koudstaal, P. J., MR CLEAN Investigators, van Zwam, W., & Dippel, D. W. J. (2017). Admission Glucose and Effect of Intra-Arterial Treatment in Patients With Acute Ischemic Stroke. Stroke, 48(5), 1299-1305. https://doi.org/10.1161/STROKEAHA.116.016071
    • Bucker, A., Boers, A. M., Bot, J. C. J., Berkhemer, O. A., Lingsma, H. F., Yoo, A. J., Van Zwam, W. H., Van Oostenbrugge, R. J., Van der Lugt, A., Dippel, D. W. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Marquering, H. A., MR CLEAN Trial Investigators, & Multictr Randomized Clinical Trial (2017). Associations of Ischemic Lesion Volume With Functional Outcome in Patients With Acute Ischemic Stroke 24-Hour Versus 1-Week Imaging. Stroke, 48(5), 1233-1240. https://doi.org/10.1161/STROKEAHA.116.015156
    • Boers, A. M. M., Berkhemer, O. A., Slump, C. H., van Zwam, W. H., Roos, Y. B. W. E. M., van der Lugt, A., van Oostenbrugge, R. J., Yoo, A. J., Dippel, D. W. J., Marquering, H. A., Majoie, C. B. L. M., & MR CLEAN Trial Investigators (2017). Topographic distribution of cerebral infarct probability in patients with acute ischemic stroke: mapping of intra-arterial treatment effect. Journal of Neurointerventional Surgery, 9(5), 431-436. https://doi.org/10.1136/neurintsurg-2016-012387
    • van den Berg, L. A., Dijkgraaf, M. G. W., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., Lingsma, H. F., Majoie, C. B. L. M., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Roos, Y. B. W. E. M., & MR CLEAN Investigators (2017). Two-Year Outcome after Endovascular Treatment for Acute Ischemic Stroke. New England Journal of Medicine, 376(14), 1341-1349. https://doi.org/10.1056/NEJMoa1612136
    • Mulder, M. J. H. L., Venema, E., Roozenbeek, B., Broderick, J. P., Yeatts, S. D., Khatri, P., Berkhemer, O. A., Roos, Y. B. W. E. M., Majoie, C. B. L. M., van Oostenbrugge, R. J., van Zwam, W. H., van der Lugt, A., Steyerberg, E. W., Dippel, D. W. J., & Lingsma, H. F. (2017). Towards personalised intra- arterial treatment of patients with acute ischaemic stroke: a study protocol for development and validation of a clinical decision aid. BMJ Open, 7(3), Article 013699. https://doi.org/10.1136/bmjopen-2016-013699
    • Wagemans, B. A. J. M., van Zwam, W. H., Nelemans, P. J., van Oostenbrugge, R. J., & Postma, A. A. (2017). 4D-CTA improves diagnostic certainty and accuracy in the detection of proximal intracranial anterior circulation occlusion in acute ischemic stroke. PLOS ONE, 12(2), Article 0172356. https://doi.org/10.1371/journal.pone.0172356
  • 2016
    • Treurniet, K. M., Yoo, A. J., Berkhemer, O. A., Lingsma, H. F., Boers, A. M. M., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Sprengers, M. E. S., Jenniskens, S. F. M., Nijeholt, G. J. L. A., van Walderveen, M. A. A., Bot, J. C. J., Beenen, L. F. M., van den Berg, R., van Zwam, W. H., van der Lugt, A., van Oostenbrugge, R. J., Dippel, D. W. J., ... Majoie, C. B. L. M. (2016). Clot Burden Score on Baseline Computerized Tomographic Angiography and Intra-Arterial Treatment Effect in Acute Ischemic Stroke. Stroke, 47(12), 2972-2978. https://doi.org/10.1161/STROKEAHA.116.014565
    • van den Berg, L. A., Dijkgraaf, M. G. W., Berkhemer, O. A., Fransen, P. S. S., Beumer, D., Lingsma, H., Majoie, C. B. M., Dippel, D. W. J., van der Lugt, A. J., van Oostenbrugge, R. J., van Zwam, W. H., & Roos, Y. B. W. E. M. (2016). Two-year clinical follow-up of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN): design and statistical analysis plan of the extended follow-up study. Trials, 17(1), Article 555. https://doi.org/10.1186/s13063-016-1669-6
    • Dippel, D. W., Majoie, C. B., Roos, Y. B., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Lingsma, H. F., Koudstaal, P. J., Treurniet, K. M., van den Berg, L. A., Beumer, D., Fransen, P. S., & Berkhemer, O. A. (2016). Influence of Device Choice on the Effect of Intra-Arterial Treatment for Acute Ischemic Stroke in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Stroke, 47(10), 2574-2581. https://doi.org/10.1161/STROKEAHA.116.013929
    • Saver, J. L., Goyal, M., van der Lugt, A., Menon, B. K., Majoie, C. B. L. M., Dippel, D. W., Campbell, B. C., Nogueira, R. G., Demchuk, A. M., Tomasello, A., Cardona, P., Devlin, T. G., Frei, D. F., de Rochemont, R. D. M., Berkhemer, O. A., Jovin, T. G., Siddiqui, A. H., van Zwam, W. H., Davis, S. M., ... Hill, M. D. (2016). Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA-Journal of the American Medical Association, 316(12), 1279-1288. https://doi.org/10.1001/jama.2016.13647
    • Al-Ali, F., Berkhemer, O. A., Yousman, W. P., Elias, J. J., Bender, E. N., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Dillon, W. P., & Majoie, C. B. L. M. (2016). The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial. Stroke, 47(9), 2286-2291. https://doi.org/10.1161/STROKEAHA.116.013513