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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Chris Reutelingsperger

Professor

Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Chris-reutelingsperger

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2024
    • Sangani, N. B., Koetsier, J., Gomes, A. R., Diogo, M. M., Fernandes, T. G., Bouwman, F. G., Mariman, E. C. M., Ghazvini, M., Gribnau, J., Curfs, L. M. G., Reutelingsperger, C. P., & Eijssen, L. M. T. (2024). Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids. Cellular and Molecular Life Sciences, 81(1), Article 410. https://doi.org/10.1007/s00018-024-05409-7
    • Amiral, J., Ferol, R., Busch, M. H., Timmermans, S. A. M. E. G., Reutelingsperger, C., & van Paassen, P. (2024). Laboratory measurement of autoantibodies to Annexin A1: Review and measurements in health and COVID-19. Transfusion and Apheresis Science, 63(6), Article 104027. https://doi.org/10.1016/j.transci.2024.104027
    • Broering, M. F., Tocci, S., Sout, N. T., Reutelingsperger, C., Farsky, S. H. P., Das, S., & Sayed, I. M. (2024). Development of an Inflamed High Throughput Stem-cell-based Gut Epithelium Model to Assess the Impact of Annexin A1. Stem Cell Reviews and Reports, 20(5), 1299-1310. https://doi.org/10.1007/s12015-024-10708-4
    • Bahram Sangani, N., Koetsier, J., Mélius, J., Kutmon, M., Ehrhart, F., Evelo, C. T., Curfs, L. M. G., Reutelingsperger, C. P., & Eijssen, L. M. T. (2024). A novel insight into neurological disorders through HDAC6 protein-protein interactions. Scientific Reports, 14(1), Article 14666. https://doi.org/10.1038/s41598-024-65094-1
    • You, W., Knoops, K., Berendschot, T. T. J. M., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2024). PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration. Cell Death Discovery, 10(1), Article 180. https://doi.org/10.1038/s41420-024-01953-0
    • Busch, M. H., Ysermans, R., Aendekerk, J., Timmermans, S. A., Potjewijd, J., Damoiseaux, J., Spronk, H. M. H., Ten Cate, H., Reutelingsperger, C., Nagy, M., & van Paassen, P. (2024). The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-Associated Vasculitis. Blood advances, 8(5), 1295-1304. https://doi.org/10.1182/bloodadvances.2023011937
    • Li, F., Chen, L., Zhong, S., Chen, J., Cao, Y., Yu, H., Ran, H., Yin, Y., Reutelingsperger, C., Shu, S., & Ling, Z. (2024). Collagen-Targeting Self-Assembled Nanoprobes for Multimodal Molecular Imaging and Quantification of Myocardial Fibrosis in a Rat Model of Myocardial Infarction. ACS Nano, 18(6), 4886-4902. https://doi.org/10.1021/acsnano.3c09801
    • Reutelingsperger, C. P. M., Gijbels, M. J., Spronk, H., Van Oerle, R., Schrijver, R., Ekhart, P., de Kimpe, S., & Nicolaes, G. A. F. (2024). M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation. International Journal of Molecular Sciences, 25(3), Article 1376. https://doi.org/10.3390/ijms25031376
    • You, W., Knoops, K., Boesten, I., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2024). A time window for rescuing dying retinal ganglion cells. Cell Communication and Signaling, 22(1), Article 88. https://doi.org/10.1186/s12964-023-01427-3
  • 2023
    • Huckriede, J. B., Beurskens, D. M. H., Wildhagen, K. C. C. A., Reutelingsperger, C. P. M., Wichapong, K., & Nicolaes, G. A. F. (2023). Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. Journal of Thrombosis and Haemostasis, 21(12), 3557-3567. https://doi.org/10.1016/j.jtha.2023.08.023
    • Sun, S., Campello, E., Zou, J., Konings, J., Huskens, D., Wan, J., Fernández, D. I., Reutelingsperger, C., Ten Cate, H., Toffanin, S., Bulato, C., de Groot, P. G., de Laat, B., Simioni, P., Heemskerk, J. W. M., & Roest, M. (2023). Crucial roles of red blood cells and platelets in whole blood thrombin generation. Blood advances, 7(21), 6717-6731. https://doi.org/10.1182/bloodadvances.2023010027
    • You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2023). Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release. Scientific Reports, 13(1), Article 11045. https://doi.org/10.1038/s41598-023-38210-w
    • Aendekerk, J. P., Ysermans, R., Busch, M. H., Theunissen, R. O. M. F. I. H., Bijnens, N., Potjewijd, J., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., & van Paassen, P. (2023). Assessment of longitudinal serum neutrophil extracellular trap-inducing activity in anti-neutrophil cytoplasmic antibody-associated vasculitis and glomerulonephritis in a prospective cohort using a novel bio-impedance technique. Kidney International, 104(1), 151-162. https://doi.org/10.1016/j.kint.2023.03.029
    • Busch, M. H., Timmermans, S. A. M. E. G., Van Kuijk, S. M. J., Aendekerk, J. P., Ysermans, R., Van Doorn, D. P. C., Potjewijd, J., Van de Poll, M. C. G., Van der Horst, I. C. C., Damoiseaux, J. G. M. C., Spronk, H. M. H., Cate, H. T., Reutelingsperger, C. P., Nagy, M., & Van Paassen, P. (2023). Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19. Haematologica-the Hematology Journal, 108(5), 1417-1422. https://doi.org/10.3324/haematol.2022.281693
    • Park, H. Y., van Bruggen, V. L. E., Peutz-Kootstra, C. J., Ophelders, D. R. M. G., Jellema, R. K., Reutelingsperger, C. P. M., Rutten, B. P. F., & Wolfs, T. G. A. M. (2023). Time Dependent Changes in the Ovine Neurovascular Unit; A Potential Neuroprotective Role of Annexin A1 in Neonatal Hypoxic-Ischemic Encephalopathy. International Journal of Molecular Sciences, 24(6), Article 5929. https://doi.org/10.3390/ijms24065929
    • de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C., & Nicolaes, G. A. F. (2023). The role of extracellular histones in COVID-19. Journal of Internal Medicine, 293(3), 275-292. https://doi.org/10.1111/joim.13585
    • Pavlic, A., Poelman, H., Wasilewski, G., Wichapong, K., Lux, P., Maassen, C., Lutgens, E., Schurgers, L. J., Reutelingsperger, C. P., & Nicolaes, G. A. F. (2023). Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. International Journal of Molecular Sciences, 24(3), Article 2027. https://doi.org/10.3390/ijms24032027
    • Sandri, S., Hebeda, C. B., Broering, M. F., Silva, M. D., Moredo, L. F., Silva, M. J. D. E., Molina, A. S., Pinto, C. A. L., Neto, J. P. D., Reutelingsperger, C. P., Gil, C. D., & Farsky, S. H. P. (2023). Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis. Cells, 12(3), Article 425. https://doi.org/10.3390/cells12030425
    • Fontaine, M. A. C., Jin, H., Gagliardi, M., Rousch, M., Wijnands, E., Stoll, M., Li, X., Schurgers, L., Reutelingsperger, C., Schalkwijk, C., van den Akker, N. M. S., Molin, D. G. M., Gullestad, L., Eritsland, J., Hoffman, P., Skjelland, M., Andersen, G. Ø., Aukrust, P., Karel, J., ... Biessen, E. A. L. (2023). Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Advanced Science, 10(5), Article 2203053. https://doi.org/10.1002/advs.202203053
    • van Smaalen, T. C., Beurskens, D. M. H., Kox, J. J. H. F. M., Polonia, R., Vos, R., Duimel, H., van de Wetering, W. J., Lopez-Iglesias, C., Reutelingsperger, C. P., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Nicolaes, G. A. F. (2023). Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model. PLOS ONE, 18(1), Article e0279944. https://doi.org/10.1371/journal.pone.0279944
  • 2022
    • Busch, M. H., Timmermans, S. A. M. E. G., Aendekerk, J. P., Ysermans, R., Amiral, J., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., & Paassen, P. V. (2022). Annexin A1 Is Associated with Adverse Clinical Outcomes in Patients with COVID-19. Journal of Clinical Medicine, 11(24), Article 7486. https://doi.org/10.3390/jcm11247486
    • Fronza Broering, M., Leão, M. C., da Rocha, G. H. O., Scharf, P. R. S., Fillipi Xavier, L., de Cristo Soares Alves, A., Castro, I., Reutelingsperger, C., Klimuk Uchiyama, M., Araki, K., Guterres, S. S., Pohlmann, A. R., & Farsky, S. H. P. (2022). Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis. European Journal of Pharmaceutics and Biopharmaceutics, 181, 49-59. https://doi.org/10.1016/j.ejpb.2022.10.022
    • Pavlic, A., Bahram Sangani, N., Kerins, J., Nicolaes, G., Schurgers, L., & Reutelingsperger, C. (2022). Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. International journal of molecular sciences, 23(16), Article 9178. https://doi.org/10.3390/ijms23169178
    • Oggero, S., Godec, T., van Gorp, R., Pinto, L. A., Schurgers, J. L., Reutelingsperger, C., Sever, P., Norling, L. V., Perretti, M., & Gupta, A. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Journal of Hypertension, 40(8), 1522-1529. https://doi.org/10.1097/HJH.0000000000003178
    • Klein, L., Ophelders, D. R. M. G., van den Hove, D., Damoiseaux, M., Rutten, B. P. F., Reutelingsperger, C. P. M., Schurgers, L. J., & Wolfs, T. G. A. M. (2022). Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis. Brain, Behavior, & Immunity - Health, 23, Article 100458. https://doi.org/10.1016/j.bbih.2022.100458
    • Petsophonsakul, P., Burgmaier, M., Willems, B., Heeneman, S., Stadler, N., Gremse, F., Reith, S., Burgmaier, K., Kahles, F., Marx, N., Natour, E., Bidar, E., Jacobs, M., Mees, B., Reutelingsperger, C., Furmanik, M., & Schurgers, L. (2022). Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells. Cardiovascular Research, 118(9), 2196-2210. https://doi.org/10.1093/cvr/cvab244
    • Jaminon, A. M. G., Rapp, N., Akbulut, A. C., Dzhanaev, R., Reutelingsperger, C. P., Jahnen-Dechent, W., & Schurgers, L. J. (2022). A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro. Journal of visualized experiment, 2022(184), Article e64029. https://doi.org/10.3791/64029
    • Gadipudi, L. L., Ramavath, N. N., Provera, A., Reutelingsperger, C., Albano, E., Perretti, M., & Sutti, S. (2022). Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis. Clinical Science, 136(9), 643-656. https://doi.org/10.1042/CS20211122
    • van Kuijk, K., Demandt, J. A. F., Perales-Patón, J., Theelen, T. L., Kuppe, C., Marsch, E., de Bruijn, J., Jin, H., Gijbels, M. J., Matic, L., Mees, B. M. E., Reutelingsperger, C. P. M., Hedin, U., Biessen, E. A. L., Carmeliet, P., Baker, A. H., Kramann, R. K., Schurgers, L. J., Saez-Rodriguez, J., & Sluimer, J. C. (2022). Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling. Cardiovascular Research, 118(5), 1232-1246. https://doi.org/10.1093/cvr/cvab152
    • You, W., Berendschot, T. T. J. M., Knoops, K., van Zandvoort, M. A. M. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2022). Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells. International journal of molecular sciences, 23(5), Article 2650. https://doi.org/10.3390/ijms23052650
    • Hrdinova, J., Fernández, D. I., Ercig, B., Tullemans, B. M. E., Suylen, D. P. L., Agten, S. M., Jurk, K., Hackeng, T. M., Vanhoorelbeke, K., Voorberg, J., Reutelingsperger, C. P. M., Wichapong, K., Heemskerk, J. W. M., & Nicolaes, G. A. F. (2022). Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. International journal of molecular sciences, 23(4), Article 2046. https://doi.org/10.3390/ijms23042046
    • Amiral, J., Busch, M. H., Timmermans, S. A. M. E. G., Reutelingsperger, C. P., & van Paassen, P. (2022). Development of IgG, IgM, and IgA Autoantibodies Against Angiotensin Converting Enzyme 2 in Patients with COVID-19. Journal of Applied Laboratory Medicine, 7(1), 382-386. https://doi.org/10.1093/jalm/jfab065
    • Sheikh, M. H., Errede, M., D'Amati, A., Khan, N. Q., Fanti, S., Loiola, R. A., McArthur, S., Purvis, G. S. D., O'Riordan, C. E., Ferorelli, D., Dell'Erba, A., Kieswich, J., Reutelingsperger, C., Maiorano, E., Yaqoob, M., Thiemermann, C., Baragetti, A., Catapano, A. L., Norata, G. D., ... Solito, E. (2022). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues. Faseb Journal, 36(1), Article e22107. https://doi.org/10.1096/fj.202101297R
  • 2021
    • Tobal, R., Potjewijd, J., van Empel, V. P. M., Ysermans, R., Schurgers, L. J., Reutelingsperger, C. P., Damoiseaux, J. G. M. C., & van Paassen, P. (2021). Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity. Frontiers in medicine, 8, Article 806899. https://doi.org/10.3389/fmed.2021.806899
    • Ercig, B., Arfman, T., Hrdinova, J., Wichapong, K., Reutelingsperger, C. P. M., Vanhoorelbeke, K., Nicolaes, G. A. F., & Voorberg, J. (2021). Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity. Journal of Biological Chemistry, 297(4), Article 101132. https://doi.org/10.1016/j.jbc.2021.101132
    • Sangani, N. B., Gomes, A. R., Curfs, L. M. G., & Reutelingsperger, C. P. (2021). The role of Extracellular Vesicles during CNS development. Progress in Neurobiology, 205, Article 102124. https://doi.org/10.1016/j.pneurobio.2021.102124
    • Chen, J. M., Norling, L. V., Mesa, J. G., Silva, M. D., Burton, S. E., Reutelingsperger, C., Perretti, M., & Cooper, D. (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America, 118(38), Article e2020385118. https://doi.org/10.1073/pnas.2020385118
    • Huckriede, J., de Vries, F., Hultstroem, M., Wichapong, K., Reutelingsperger, C., Lipcsey, M., de Frutos, P. G., Frithiof, R., & Nicolaes, G. A. F. (2021). Histone H3 Cleavage in Severe COVID-19 ICU Patients. Frontiers in Cellular and Infection Microbiology, 11, Article 694186. https://doi.org/10.3389/fcimb.2021.694186
    • van Gorp, R. H., Baaten, C. C. F. M. J., Habibi, A., Jaminon, A. M. G., Peeters, F. E. C. M., Leenders, P., Crijns, H. J. G. M. C., Heemskerk, J. W. M., Reutelingsperger, C. P., Spronk, H. M., & Schurgers, L. J. (2021). Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability. European heart journal open, 1(2), Article oeab017. https://doi.org/10.1093/ehjopen/oeab017
    • Huckriede, J., Anderberg, S. B., Morales, A., de Vries, F., Hultstrom, M., Bergqvist, A., Ortiz-Perez, J. T., Sels, J. W., Wichapong, K., Lipcsey, M., van de Poll, M., Larsson, A., Luther, T., Reutelingsperger, C., Garcia de Frutos, P., Frithiof, R., & Nicolaes, G. A. F. (2021). Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Scientific Reports, 11(1), Article 15701. https://doi.org/10.1038/s41598-021-95209-x
    • Jaminon, A. M. G., Akbulut, A. C., Rapp, N., Kramann, R., Biessen, E. A. L., Temmerman, L., Mees, B., Brandenburg, V., Dzhanaev, R., Jahnen-Dechent, W., Floege, J., Uitto, J., Reutelingsperger, C. P., & Schurgers, L. J. (2021). Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity. Cells, 10(8), Article 2097. https://doi.org/10.3390/cells10082097
    • Liu, X., Arfman, T., Wichapong, K., Reutelingsperger, C. P. M., Voorberg, J., & Nicolaes, G. A. F. (2021). PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune-mediated disease. Journal of Thrombosis and Haemostasis, 19(7), 1607-1617. https://doi.org/10.1111/jth.15313
    • Ercig, B., Gomes Graca, N. A., Kangro, K., Arfman, T., Wichapong, K., Hrdinova, J., Kaijen, P., van Alphen, F., van den Biggelaar, M., Vanhoorelbeke, K., Veyradier, A., Coppo, P., Reutelingsperger, C., Nicolaes, G. A. F., Männik, A., & Voorberg, J. (2021). N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP. Blood, 137(19), 2694-2698. https://doi.org/10.1182/blood.2020007972
    • Ries, M., Watts, H., Mota, B. C., Lopez, M. Y., Donat, C. K., Baxan, N., Pickering, J. A., Chau, T. W., Semmler, A., Gurung, B., Aleksynas, R., Abelleira-Hervas, L., Iqbal, S. J., Romero-Molina, C., Hernandez-Mir, G., D'Amati, A., Reutelingsperger, C., Goldfinger, M. H., Gentleman, S. M., ... Sastre, M. (2021). Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. Brain, 144(5), 1526-1541. https://doi.org/10.1093/brain/awab050
    • Liu, X., Wichapong, K., Lamers, S., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2021). Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies. International Journal of Biochemistry & Cell Biology, 134, Article 105938. https://doi.org/10.1016/j.biocel.2021.105938
    • van Gorp, R. H., Dijkgraaf, I., Bröker, V., Bauwens, M., Leenders, P., Jennen, D., Dweck, M. R., Bucerius, J., Briedé, J. J., van Ryn, J., Brandenburg, V., Mottaghy, F., Spronk, H. M. H., Reutelingsperger, C. P., & Schurgers, L. J. (2021). Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate. Journal of Thrombosis and Haemostasis, 19(5), 1348-1363. https://doi.org/10.1111/jth.15289
    • Timmermans, S. A. M. E. G., Damoiseaux, J. G. M. C., Werion, A., Reutelingsperger, C. P., Morelle, J., & van Paassen, P. (2021). Functional and Genetic Landscape of Complement Dysregulation Along the Spectrum of Thrombotic Microangiopathy and its Potential Implications on Clinical Outcomes. Kidney International Reports, 6(4), 1099-1109. https://doi.org/10.1016/j.ekir.2021.01.034
    • Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zat'ovicova, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., Cleutjens, K. B. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., van Greevenbroek, M. M. J., Biessen, E. A. L., Pasterkamp, G., Pastorekova, S., Stehouwer, C. D. A., & Sluimer, J. C. (2021). The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease. Scientific Reports, 11(1), Article 425. https://doi.org/10.1038/s41598-020-79978-5
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