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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Chris Reutelingsperger

Professor

Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Chris-reutelingsperger

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2003
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2003). Low concentrations of ethanol induce apoptosis in human intestinal cells. Scandinavian Journal of Gastroenterology, 38(11), 1154-1161. https://doi.org/10.1080/00365520310006252
    • Notenboom, R. G., van den Bergh, M. A., Dingemans, K. P., Vermeulen, J. L., van den Eijnde, S. M., Reutelingsperger, C. P. M., Hut, H., Willemsen, R., Offerhaus, G. J., & Lamers, W. H. (2003). Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. Hepatology, 38(3), 683-691. https://doi.org/10.1053/jhep.2003.50365
  • 2002
    • Franssen, E. J., Rombout-Sestrienkova, E., van Pampus, E. C. M., Buurman, W. A., Reutelingsperger, C. P. M., & Maessen, J. G. (2002). Prestorage leucocyte reduction of red cell components prevents release of bactericidal permeability increasing protein and defensins. Vox Sanguinis, 83(2), 119-124. https://doi.org/10.1046/j.1423-0410.2002.00193.x
  • 2001
    • van den Eijnde, S. M., van den Hoff, M. J. B., Reutelingsperger, C. P. M., van Heerde, W. L., Henfling, M. E. R., Vermeij-Keers, C., Schutte, B., Borgers, M., & Ramaekers, F. C. S. (2001). Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. Journal of Cell Science, 114(20), 3631-3642. https://doi.org/10.1242/jcs.114.20.3631
  • 2000
    • Terwel, D., Nieland, L. J. W., Schutte, B., Reutelingsperger, C. P. M., Ramaekers, F. C. S., & Steinbusch, H. W. M. (2000). S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.European Journal of Pharmacology, 400, 400-400. https://doi.org/10.1016/S0014-2999(00)00379-4
  • 1999
    • Heemskerk, J. W. M., Siljander, P. R. M., Vuist, M. W. J., Breikers, G., Reutelingsperger, C. P. M., Barnes, M. J., Knight, C. G., Lassila, R., & Farndale, R. W. (1999). Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets.Thrombosis and Haemostasis, 81(5), 782-792. https://doi.org/10.1055/s-0037-1614571
    • van Gorp Beisser, R. M. A., Broers, J. L. V., Reutelingsperger, C. P. M., Bronnenberg, N. M. H. J., Hornstra, G., Mieras-van Dam, M. C. E., & Heemskerk, J. W. M. (1999). Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis.American Journal of Physiology (Consolidated), 277(1 Pt 1), C20-C28. https://doi.org/10.1152/ajpcell.1999.277.1.C20
  • 1997
    • Heemskerk, J. W. M., Vuist, M. W. J., Feijge, M. A. H., Reutelingsperger, C. P. M., & Lindhout, T. (1997). Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses.Blood, 90(7), 2615-2625. https://doi.org/10.1182/BLOOD.V90.7.2615
  • 1996
    • IJzendoorn, S. C. D., van Gool, R. G. J., Reutelingsperger, C. P. M., & Heemskerk, J. W. M. (1996). Unstimulated platelets evoke calcium responses in human umbilical vein endothelial cells.Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides, 1311, 64-70. https://doi.org/10.1016/0167-4889(95)00191-3
  • 1994
    • van Heerde, W. L., Sakariassen, K. S., Hemker, H. C., Sixma, J. J., Reutelingsperger, C. P. M., & de Groot, P. G. (1994). Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions. Arteriosclerosis and thrombosis, 14(5), 824-830. https://doi.org/10.1161/01.ATV.14.5.824
  • 1992
    • Lindhout, T., Blezer, R., Schoen, P., Nordfang, O., Reutelingsperger, C., & Hemker, H. C. (1992). Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells. Blood, 79(11), 2909-2916. https://doi.org/10.1182/BLOOD.V79.11.2909.2909
    • Andree, H. A. M., Stuart, M. C. A., Hermens, W. T., Reutelingsperger, C. P. M., Hemker, H. C., Frederik, P. M., & Willems, G. M. (1992). Clustering of lipid-bound Annexin V may explain its anticoagulant effect. Journal of Biological Chemistry, 267(25), 17907-17912. https://doi.org/10.1016/S0021-9258(19)37128-5
  • 1990
    • Andree, H. A. M., Reutelingsperger, C. P. M., Hauptmann, R., Hemker, H. C., Hermens, W. T., & Willems, G. (1990). Binding of vascular anticoagulant α(VACα) to Planar Phospholipid Bilayers. Journal of Biological Chemistry, 265(9), 4923-4928. https://doi.org/10.1016/S0021-9258(19)34062-1
  • 1988
    • Reutelingsperger, C. P. M., Kop, J. M. M., Hornstra, G., & Hemker, H. C. (1988). Purification and characterization of a novel protein from bovine aorta that inhibits coagulation. European Journal of Biochemistry, 173(1), 171-178. https://doi.org/10.1111/j.1432-1033.1988.tb13981.x
  • 1985
    • Reutelingsperger, C. P. M., Hornstra, G., & Hemker, H. C. (1985). Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. European Journal of Biochemistry, 151(3), 625-629. https://doi.org/10.1111/j.1432-1033.1985.tb09150.x
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