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ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

20 August 2024

The project 'Impact of COVID-19 protective measures and shielding in vulnerable patients with kidney failure', coordinated by Prof. Marc Hemmelder and Drs Pim Bouwmans (Dept of Internal Medicine), has been granted by ZonMw. 

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Professorship Henri Spronk

Professorship Henri Spronk

12 August 2024

Dr Henri Spronk (Dept of Biochemistry) has been appointed as professor of ‘Biochemistry of Atherothrombosis’ as of 1 May 2024.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2021
    • Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J. L., Boveda, S., & Duncker, D. (2021). Use and misuse of instant messaging in clinical data sharing: the EHRA-SMS survey. EP Europace, 23(8), 1326-1330. https://doi.org/10.1093/europace/euab063
    • Linz, D., Linz, B., Dobrev, D., Baumert, M., Hendriks, J. M., Pepin, J.-L., & Jespersen, T. (2021). Personalized management of sleep apnea in patients with atrial fibrillation: An interdisciplinary and translational challenge. IJC Heart & Vasculature, 35, Article 100843. https://doi.org/10.1016/j.ijcha.2021.100843
    • Gawalko, M., Duncker, D., Manninger, M., van der Velden, R. M. J., Hermans, A. N. L., Verhaert, D. V. M., Pison, L., Pisters, R., Hemels, M., Sultan, A., Steven, D., Gupta, D., Heidbuchel, H., Sohaib, A., Wijtvliet, P., Tieleman, R., Gruwez, H., Chun, J. L., Schmidt, B., ... TeleCheck-AF investigators (2021). The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences. EP Europace, 23(7), 1003-1015. https://doi.org/10.1093/europace/euab050
    • Fisser, C., Bureck, J., Gall, L., Vaas, V., Priefert, J., Fredersdorf, S., Zeman, F., Linz, D., Wohrle, H., Tamisier, R., Teschler, H., Cowie, M. R., & Arzt, M. (2021). Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea. ERJ Open Research, 7(3), Article 00147-2021. https://doi.org/10.1183/23120541.00147-2021
    • Scott, L., Fender, A. C., Saljic, A., Li, L., Chen, X., Wang, X., Linz, D., Lang, J., Hohl, M., Twomey, D., Pham, T. T., Diaz-Lankenau, R., Chelu, M. G., Kamler, M., Entman, M. L., Taffet, G. E., Sanders, P., Dobrev, D., & Li, N. (2021). NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovascular Research, 117(7), 1746-1759. https://doi.org/10.1093/cvr/cvab024
    • Shahrbabaki, S. S., Linz, D., Hartmann, S., Redline, S., & Baumert, M. (2021). Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. European Heart Journal, 42(21), 2088-2099. https://doi.org/10.1093/eurheartj/ehab151
    • Gawalko, M., Linz, D., & Dobrev, D. (2021). Gut-microbiota derived TMAO: A risk factor, a mediator or a bystander in the pathogenesis of atrial fibrillation?IJC Heart & Vasculature, 34, Article 100818. https://doi.org/10.1016/j.ijcha.2021.100818
    • Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erkuner, O., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2021). Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Netherlands Heart Journal, 29(5), 255-261. https://doi.org/10.1007/s12471-020-01528-5
    • Pluymaekers, N. A. H. A., van der Velden, R. M. J., Hermans, A. N. L., Gawalko, M., Buskes, S., Keijenberg, J. J. H. M. W., Vorstermans, B., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). On-Demand Mobile Health Infrastructure for Remote Rhythm Monitoring within a Wait-and-See Strategy for Recent-Onset Atrial Fibrillation: TeleWAS-AF. Cardiology, 146(3), 392-396. https://doi.org/10.1159/000514156
    • Hermans, A. N. L., Gawalko, M., Pluymaekers, N. A. H. A., Dinh, T., Weijs, B., van Mourik, M. J. W., Vorstermans, B., den Uijl, D. W., Opsteyn, L., Snippe, H., Vernooy, K., Crijns, H. J. G. M., Linz, D., & Luermans, J. G. L. M. (2021). Long-term intermittent versus short continuous heart rhythm monitoring for the detection of atrial fibrillation recurrences after catheter ablation. International Journal of Cardiology, 329, 105-112. https://doi.org/10.1016/j.ijcard.2020.12.077
    • Linz, D., & Dobrev, D. (2021). A disproportional rise in the growing submission rate to International Journal of Cardiology Heart & Vasculature during the COVID‑19 pandemic. IJC Heart and Vasculature, 33, Article 100749. https://doi.org/10.1016/j.ijcha.2021.100749
    • Linz, D., Hermans, A., & Tieleman, R. G. (2021). Early atrial fibrillation detection and the transition to comprehensive management. EP Europace, 23, II46-II51. https://doi.org/10.1093/europace/euaa424
    • Linz, D., Linz, B., Homberg, M., Bouman, E., Dobrev, D., Hendriks, J. M., & Simons, S. O. (2021). Obstructive respiratory events during procedural sedation and analgesia: Another WHY to routinely screen for sleep apnea before catheter ablation of atrial fibrillation. IJC Heart and Vasculature, 33, Article 100783. https://doi.org/10.1016/j.ijcha.2021.100783
    • Betz, K., Knuf, F., Duncker, D., Giordano, M., Dobrev, D., & Linz, D. (2021). The impact of Twitter promotion on future citation rates: The #TweetTheJournal study. IJC Heart and Vasculature, 33, Article 100776. https://doi.org/10.1016/j.ijcha.2021.100776
    • Heijman, J., Ghossein, M. A., Vernooy, K., & Linz, D. (2021). The walk of life: Remote monitoring provides insights into physical activity during a pandemic. IJC Heart and Vasculature, 33, Article 100772. https://doi.org/10.1016/j.ijcha.2021.100772
    • Linz, D., Homberg, M., van der Velden, R. M. J., Bouman, E., Buhre, W., & Simons, S. O. (2021). Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. International Journal of Cardiology, 327, 102-104. https://doi.org/10.1016/j.ijcard.2020.10.080
    • Linz, D., Malfertheiner, M. V., Werner, N., Lerzer, C., Gfullner, F., Linz, B., Zeman, F., McEvoy, R. D., Arzt, M., & Baumert, M. (2021). Nocturnal hypoxemic burden during positive airway pressure treatment across different central sleep apnea etiologies. Sleep Medicine, 79, 62-70. https://doi.org/10.1016/j.sleep.2021.01.007
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., den Uijl, D. W., Buskes, S., Vernooy, K., Crijns, H. J. G. M., Hendriks, J. M., & Linz, D. (2021). Implementation of an on-demand app-based heart rate and rhythm monitoring infrastructure for the management of atrial fibrillation through teleconsultation: TeleCheck-AF. EP Europace, 23(3), 345-352. https://doi.org/10.1093/europace/euaa201
    • Vaas, V., Fisser, C., Tafelmeier, M., Linz, D., & Arzt, M. (2021). Interaktionen schlafbezogener Atmungsstörungen mit Vorhofflimmern. Somnologie, 25(1), 38-44. https://doi.org/10.1007/s11818-020-00271-8
    • Linz, B., Hohl, M., Lang, L., Wong, D. W. L., Nickel, A. G., De La Torre, C., Sticht, C., Wirth, K., Boor, P., Maack, C., Speer, T., Jespersen, T., Schotten, U., Sanders, P., Bohm, M., & Linz, D. (2021). Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm, 18(3), 455-464. https://doi.org/10.1016/j.hrthm.2020.10.011
    • Heijman, J., Luermans, J. G. L. M., Linz, D., van Gelder, I. C., & Crijns, H. J. G. M. (2021). Risk Factors for Atrial Fibrillation Progression. Cardiac Electrophysiology Clinics, 13(1), 201-209. https://doi.org/10.1016/j.ccep.2020.10.011
    • Linz, D., Nattel, S., Kalman, J. M., & Sanders, P. (2021). Sleep Apnea and Atrial Fibrillation. Cardiac Electrophysiology Clinics, 13(1), 87-94. https://doi.org/10.1016/j.ccep.2020.10.003
    • Heijman, J., Linz, D., & Schotten, U. (2021). Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annual Review of Physiology, 83, 83-106. https://doi.org/10.1146/annurev-physiol-031720-085307
    • Hermans, B. J. M., & Linz, D. (2021). Abnormal electrograms during sinus rhythm for VT ablation: Beware of Fata Morganas. Journal of Cardiovascular Electrophysiology, 32(2), 389-390. https://doi.org/10.1111/jce.14855
    • Simons, S. O., Elliott, A., Sastry, M., Hendriks, J. M., Arzt, M., Rienstra, M., Kalman, J. M., Heidbuchel, H., Nattel, S., Wesseling, G., Schotten, U., van Gelder, I. C., Franssen, F. M. E., Sanders, P., Crijns, H. J. G. M., & Linz, D. (2021). Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective. European Heart Journal, 42(5), 532-540. https://doi.org/10.1093/eurheartj/ehaa822
  • 2020
    • Hendriks, J. M., & Linz, D. (2020). Screening for obstructive sleep apnoea in patients with atrial fibrillation: Much more than a screening tool alone. IJC Heart and Vasculature, 31, Article 100655. https://doi.org/10.1016/j.ijcha.2020.100655
    • Linz, D., & Dobrev, D. (2020). Sleep apnea and atrial fibrillation: Update 2020. IJC Heart and Vasculature, 31, Article 100681. https://doi.org/10.1016/j.ijcha.2020.100681
    • Hermans, A. N. L., Andrade, J. G., & Linz, D. (2020). Arterial Stiffness Association With Symptom Burden in Patients With Atrial Fibrillation: Direct Cause or Marker of Concomitant Risk Factors?Canadian Journal of Cardiology, 36(12), 1843-1846. https://doi.org/10.1016/j.cjca.2020.08.003
    • Linz, D., Loffler, K. A., Sanders, P., Catcheside, P., Anderson, C. S., Zheng, D., Quan, W., Barnes, M., Redline, S., McEvoy, R. D., Baumert, M., & SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators (2020). Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk Post Hoc Analyses of the SAVE Study. Chest, 158(6), 2621-2631. https://doi.org/10.1016/j.chest.2020.06.072
    • Linz, D., & Duncker, D. (2020). Twitter in der Kardiologie: Praktische Anleitung für den professionellen Gebrauch. Herzschrittmachertherapie und Elektrophysiologie, 31(4), 388-393. https://doi.org/10.1007/s00399-020-00699-3
    • Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., Verhaert, D. V. M., Desteghe, L., Duncker, D., Manninger, M., Heidbuchel, H., Pisters, R., Hemels, M., Pison, L., Sohaib, A., Sultan, A., Steven, D., Wijtvliet, P., Tieleman, R., Gupta, D., Dobrev, D., Svennberg, E., ... TeleCheck-AF investigators (2020). On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation. Clinical Cardiology, 43(11), 1232-1239. https://doi.org/10.1002/clc.23469
    • Bejinariu, A. G., Makimoto, H., Wakili, R., Mathew, S., Kosiuk, J., Linz, D., Steinfurt, J., Dechering, D. G., Meyer, C., Veltmann, C., Kelm, M., Frommeyer, G., Eckardt, L., Deneke, T., Duncker, D., & Muller, P. (2020). One-Year Course of Periprocedural Anticoagulation in Atrial Fibrillation Ablation: Results of a German Nationwide Survey. Cardiology, 145(10), 676-681. https://doi.org/10.1159/000509399
    • Linz, D., van der Velden, R. M. J., Gawalko, M., Hermans, A. N. L., Pluymaekers, N. A. H. A., & Hendriks, J. M. (2020). Remote management and education in patients with cardiovascular conditions during COVID-19 and beyond. IJC Heart and Vasculature, 30, Article 100646. https://doi.org/10.1016/j.ijcha.2020.100646
    • Linz, D., & Hendriks, J. (2020). Central sleep apnea in atrial fibrillation: Risk factor or marker of untreated underlying disease?IJC Heart & Vasculature, 30, Article 100650. https://doi.org/10.1016/j.ijcha.2020.100650
    • Gawalko, M., Kaplon-Cieslicka, A., Hohl, M., Dobrev, D., & Linz, D. (2020). COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications. IJC Heart & Vasculature, 30, Article 100631. https://doi.org/10.1016/j.ijcha.2020.100631
    • Bogossian, H., Linz, D., Heijman, J., Bimpong-Buta, N.-Y., Bandorski, D., Frommeyer, G., Erkapic, D., Seyfarth, M., Zarse, M., & Crijns, H. J. (2020). QTc evaluation in patients with bundle branch block. IJC Heart & Vasculature, 30, Article 100636. https://doi.org/10.1016/j.ijcha.2020.100636
    • Pluymaekers, N. A. H. A., Linz, D. K., Rienstra, M., van Gelder, I. C., & Crijns, H. J. G. M. (2020). Emergency department cardioversion of acute atrial fibrillation. Lancet, 396(10255), 884-885. https://doi.org/10.1016/S0140-6736(20)31311-8
    • Hohl, M., Mayr, M., Lang, L., Nickel, A. G., Barallobre-Barreiro, J., Yin, X., Speer, T., Selejan, S.-R., Goettsch, C., Erb, K., Fecher-Trost, C., Reil, J.-C., Linz, B., Ruf, S., Huebschle, T., Maack, C., Boehm, M., Sadowski, T., & Linz, D. (2020). Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry, 295(36), 12605-12617. https://doi.org/10.1074/jbc.RA120.013488
    • van der Velden, R. M. J., Hermans, A. N. L., Pluymaekers, N. A. H. A., Gawalko, M., Vorstermans, B., Martens, H., Buskes, S., Crijns, H. J. G. M., Linz, D., & Hendriks, J. M. (2020). Coordination of a remote mHealth infrastructure for atrial fibrillation management during COVID-19 and beyond: TeleCheck-AF. International Journal of Care Coordination, 23(2-3), 65-70. Article 2053434520954619. https://doi.org/10.1177/2053434520954619
    • Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart & Vasculature, 29, Article 100591. https://doi.org/10.1016/j.ijcha.2020.100591
    • De With, R. R., Erkuner, O., Rienstra, M., Nguyen, B.-O., Korver, F. W. J., Linz, D., Ten, H. C., Spronk, H., Kroon, A. A., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., de Groot, J. R., Elvan, A., de Melis, M., Scheerder, C. O. S., Al-Jazairi, M. I. H., Schotten, U., ... RACE V Investigators (2020). Temporal patterns and short-term progression of paroxysmal atrial fibrillation data from RACE V. EP Europace, 22(8), 1162-1172. https://doi.org/10.1093/europace/euaa123
    • Gawalko, M., Jespersen, T., Dobrev, D., & Linz, D. (2020). The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?IJC Heart & Vasculature, 29, Article 100581. https://doi.org/10.1016/j.ijcha.2020.100581
    • Khan, A., Hasan, F., Bandorski, D., Lemke, B., Linz, D., Zarse, M., Bimpong-Buta, N.-Y., & Bogossian, H. (2020). Transaortic pulmonary vein isolation in the presence of situs inversus and total venous anomaly; technical capabilities for 3D reconstruction and considerations of adequate choice of ablation catheters. IJC Heart & Vasculature, 29, Article 100577. https://doi.org/10.1016/j.ijcha.2020.100577
    • Desteghe, L., Linz, D., & Hendriks, J. M. (2020). Sleep Apnea Testing and Management in Patients With Atrial Fibrillation Why is it So Difficult?Journal of Cardiovascular Nursing, 35(4), 324-326. https://doi.org/10.1097/JCN.0000000000000668
    • Linz, D., Pluymaekers, N. A. H. A., Hendriks, J. M., & TeleCheck-AF investigators (2020). TeleCheck-AF for COVID-19. European Heart Journal, 41(21), 1954-1955. https://doi.org/10.1093/eurheartj/ehaa404
    • Pluymaekers, N. A. H. A., Hermans, A. N. L., van der Velden, R. M. J., den Uijl, D. W., Vorstermans, B., Buskes, S., Hendriks, J. M., Vernooy, K., Crijns, H. J. G. M., & Linz, D. (2020). On-demand app-based rate and rhythm monitoring to manage atrial fibrillation through teleconsultations during COVID-19. IJC Heart & Vasculature, 28, Article 100533. https://doi.org/10.1016/j.ijcha.2020.100533
    • Linz, B., Hohl, M., Mishima, R., Saljic, A., Lau, D. H., Jespersen, T., Schotten, U., Sanders, P., & Linz, D. (2020). Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats. IJC Heart & Vasculature, 28, Article 100534. https://doi.org/10.1016/j.ijcha.2020.100534
    • Linz, D., Linz, B., & Heijman, J. (2020). Sleep Apnea, Intermittent Hypoxemia, and Effects on Ischemic Myocardial Damage: Friend or Foe?Canadian Journal of Cardiology, 36(6), 809-812. https://doi.org/10.1016/j.cjca.2020.02.075
    • Linz, D., & Crijns, H. J. G. M. (2020). Alcohol Abstinence in Drinkers with Atrial Fibrillation. New England Journal of Medicine, 382(18), 1768-1768. https://doi.org/10.1056/NEJMc2001512
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