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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Otto Bekers

Professor

Prof. Otto Bekers studied Pharmacy at the University of Leiden and graduated in 1987 with honour. He recieved his PhD degree in 1991 at the Utrecht University, title of his dissertation was 'Inclusion comlexation of cyclodextrins with some cytostatic drugs'. After this he specialised in Clinical Chemistry at the Leyenburg Hospital (now Haga Hospital) in The Hague.

Since 1997 he is working as a Clinical Chemist at the Maastricht UMC+. First as head of the unit General Clinical Chemistry and from 2014 he is professor in Clinical Chemistry and head of the Central Diagnostic Laboratory (CDL).

He is heading the cardiac marker research at the CDL and also focussed on personalised medice.

Otto-bekers

Central Diagnostic Laboratory
P. Debyelaan 25, 6229 HX Maastricht
PO Box 5800, 6202 AZ Maastricht
Room number: 5.E2.004
T: +31 (0)43 387 646 94

  • 2010
    • de Boer, D., Houben, C., Bekers, O., & Menheere, P. P. C. A. (2010). Gelofusine (R) affects the quality control performance of QuickVue (R) point-of-care human chorionic gonadotropin test devices. Clinical Biochemistry, 43(16-17), 1371-1372. https://doi.org/10.1016/j.clinbiochem.2010.08.017
    • Cranenburg, E. C. M., Koos, R., Schurgers, L. J., Magdeleyns, E. J. P., Schoonbrood, T. H. M., Landewe, R. B., Brandenburg, V. M., Bekers, O., & Vermeer, C. (2010). Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thrombosis and Haemostasis, 104(4), 811-822. https://doi.org/10.1160/TH09-11-0786
    • Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2010). Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms.Current Opinion in Pulmonary Medicine, 16(5), 496-502. https://doi.org/10.1097/MCP.0b013e32833c06f1
    • Lind, J. S., Dingemans, A. M., Groen, H. J., Thunnissen, F. B., Bekers, O., Heideman, D. A., Honeywell, R. J., Giovannetti, E., Peters, G. J., Postmus, P. E., van Suylen, R. J., & Smit, E. F. (2010). A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer. Clinical Cancer Research, 16(11), 3078-3087. https://doi.org/10.1158/1078-0432.CCR-09-3033
    • Wijnen, P. A., Nelemans, P. J., Verschakelen, J. A., Bekers, O., Voorter, C. E., & Drent, M. (2010). The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis.Tissue Antigens, 75(3), 262-268. https://doi.org/10.1111/j.1399-0039.2009.01437.x
    • Wijnen, P. A. H. M., Bekers, O., & Drent, M. (2010). 'Drug'-induced pneumonitis associated with CYP and VKORC1 variants.The Bulletin of contemporary clinical medicine, 3, 15-17. https://doi.org/10.20969/VSKM.2010.3(4).15-17
    • Wijnen, P. A., Bekers, O., van Dieijen-Visser, M. P., & Drent, M. (2010). Pharmacogenetic testing after a simple DNA isolation method.The Bulletin of contemporary clinical medicine, 3, 9-14. https://doi.org/10.20969/VSKM.2010.3(4).9-14
    • Wijnen, P. A., Linssen, C. F., Haenen, G. R., Bekers, O., & Drent, M. (2010). Variant VKORC1 and CYP2C9 Alleles in Patients with Diffuse Alveolar Hemorrhage Caused by Oral Anticoagulants. Molecular Diagnosis & Therapy, 14(1), 23-30. https://doi.org/10.1007/BF03256350
  • 2009
    • Wijnen, P. A., Limantoro, I., Drent, M., Bekers, O., Kuijpers, P. M., & Koek, G. H. (2009). Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity. Annals of Clinical Biochemistry, 46(Pt 6), 527-30. https://doi.org/10.1258/acb.2009.009003
    • Wolfs, J. L., Comfurius, P., Bekers, O., Zwaal, R. F., Balasubramanian, K., Schroit, A. J., Lindhout, T., & Bevers, E. M. (2009). Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions. Cellular and Molecular Life Sciences, 66(2), 314-23. https://doi.org/10.1007/s00018-008-8566-4
    • Lind, J. S., Postmus, P. E., Heideman, D. A., Thunnissen, E. B., Bekers, O., & Smit, E. F. (2009). Dramatic response to low-dose erlotinib of epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer after severe cutaneous toxicity. Journal of Thoracic Oncology, 4(12), 1585-6. https://doi.org/10.1097/JTO.0b013e3181bbb2b9
    • Wijnen, P. A. H. M., Drent, M., van Dieijen-Visser, M. P., & Bekers, O. (2009). Pharmacogenetic testing after a simple DNA isolation method on buccal swab samples. Pharmacogenomics, 10(6), 983-7. https://doi.org/10.2217/pgs.09.4
  • 2008
    • Linssen, C. F. M., Bekers, O., Drent, M., & Jacobs, J. A. (2008). C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia. Annals of Clinical Biochemistry, 45(Pt 3), 293-8. https://doi.org/10.1258/acb.2007.007133
    • van Schaik, R. H. N., Grandia, L., de Goede, A., Bet, P. M., Bekers, O., Guchelaar, H. J., Goldschmidt, H. M. J., Meijer, M. M. C., Mulder, H., van der Weide, J., & Deneer, V. H. M. (2008). CYP2D6 genotype `1-0' ingedeeld als intermediaire metaboliseerder.Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 33(1), 52.
    • Wijnen, P. A. H. M., op den Buijsch, R. A., Cheung, S. C., van der Heijden, J., Hoogtanders, K., Stolk, L. M. L., van Dieijen-Visser, M., Neef, C. K., Drent, M., & Bekers, O. (2008). Genotyping with a dried blood spot method: a useful technique for application in pharmacogenetics. Clinica Chimica Acta, 388(1-2), 189-91. https://doi.org/10.1016/j.cca.2007.10.001
    • Wijnen, P. A. H. M., Drent, M., Nelemans, P. J., Kuijpers, P. M., Koek, G. H., Neef, C. K., Haenen, G. R., & Bekers, O. (2008). Role of cytochrome p450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands. Drug Safety, 31(12), 1125-34. https://doi.org/10.2165/0002018-200831120-00008
    • Ramakers, I. H. G. B., Visser, P. J., Aalten, P., Bekers, O., Sleegers, K., van Broeckhoven, C. L., Jolles, J., & Verhey, F. R. (2008). The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology. Dementia and Geriatric Cognitive Disorders, 26(2), 101-8. https://doi.org/10.1159/000144072
  • 2007
    • op den Buijsch, R. A., van de Plas, A., Stolk, L. M. L., Christiaans, M. H., van Hooff, J. P., Undre, N. A., van Dieijen-Visser, M. P., & Bekers, O. (2007). Evaluation of limited sampling strategies for tacrolimus. European Journal of Clinical Pharmacology, 63(11), 1039-1044. https://doi.org/10.1007/s00228-007-0354-9
    • Veltkamp, M., Wijnen, P. A. H. M., Moorsel, C. H., Rijkers, G. T., Ruven, H. J., Heron, M., Bekers, O., Claessen, A. M., Drent, M., Van den Bosch, J. M. M., & Grutters, J. C. (2007). Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.Clinical and Experimental Immunology, 149(3), 453-462. https://doi.org/10.1111/j.1365-2249.2007.03428.x
    • Wijnen, P. A. H. M., Op den Buisch, R., Drent, M., Kuipers, P. M. J. C., Neefs, C., Bast, A., Bekers, O., & Koek, G. H. (2007). Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms.Alimentary Pharmacology & Therapeutics, 26(2), 211-219. https://doi.org/10.1111/j.1365-2036.2007.03490.x
    • op den Buijsch, R. A., Christiaans, M. H., Stolk, L. M. L., de Vries, J. E., Cheung, C. Y., Undre, N. A., van Hooff, J. P., van Dieijen-Visser, M. P., & Bekers, O. (2007). Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundamental & Clinical Pharmacology, 21(4), 427-435. https://doi.org/10.1111/j.1472-8206.2007.00504.x
    • Llerena, A., Michel, G., Jeannesson, E., Wong, S., Manolopoulos, V. G., Hockett, R. D., Boubekeur, K., Siest, G., Beaune, P., Haefliger, C., Arnold, H. P., Junien, C., Petrovic, N., Molloy, R., Bekers, O., Donnelly, C., Arens, H. J., Kaput, J., & McComb, J. (2007). Third Santorini conference pharmacogenomics workshop report: "Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?". Clinical Chemistry and Laboratory Medicine, 45(7), 843-850. https://doi.org/10.1515/CCLM.2007.182
  • 2005
    • Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740. https://doi.org/10.1515/CCLM.2005.125
    • op den Buijsch, R. A., de Vries, J. E., Loots, W. J., Landt, O., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., & Bekers, O. (2005). Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes. Pharmacogenomics, 5(2), 72-74. https://doi.org/10.1038/sj.tpj.6500299
    • Beerenhout, C. H., Luik, A. J., Jeuken Mertens, S. G., Bekers, O., Menheere, P. P., Hover, L., Klaassen, L., van der Sande, F. M., Cheriex, E. C., Meert, N., Leunissen, K. M. L., & Kooman, J. P. (2005). Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study. Nephrology Dialysis Transplantation, 20(6), 1155-1163. https://doi.org/10.1093/ndt/gfh775
    • op den Buijsch, R. A., Wijnen, P. A. H. M., van Dieijen-Visser, M. P., de Vries, J. E., & Bekers, O. (2005). Rapid genotyping of the OATP1B1 polymorphisms A388G and T521C with real-time PCR FRET assays. Pharmacogenomics, 6(4), 393-397. https://doi.org/10.1517/14622416.6.4.393
  • 2004
    • Beerenhout, C., Noris, M., Kooman, J. P., Porrati, F., Binda, E., Morigi, M., Bekers, O., van der Sande, F. M., Todeschini, M., Macconi, D., Leunissen, K. M. L., & Remuzzi, F. R. C. P. (2004). Nitric oxide synthetic capacity in relation to dialysate temperature. Blood Purification, 22(2), 203-209. https://doi.org/10.1159/000076854
    • van Boxtel, M. P. J., Menheere, P. P. C. A., Bekers, O., Hogervorst, E., & Jolles, J. (2004). Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology, 29(7), 891-898. https://doi.org/10.1016/j.psyneuen.2003.08.002
  • 2003
    • Rothkrantz-Kos, S., Bekers, O., Gubbels, A., Drent, M., Schmitz, M. P., & van Dieijen-Visser, M. P. (2003). Evaluation of two new high-sensitivity methods for C-reactive protein. Annals of Clinical Biochemistry, 40(Pt 4), 398-405. https://doi.org/10.1258/000456303766477057
  • 2002
    • Rothkrantz-Kos, S., Schmitz, M. P. J., Bekers, O., Menheere, P. P. C. A., & van Dieijen-Visser, M. P. (2002). High-sensitivity C-reactive protein methods examined. Clinical Chemistry, 48(2), 359-362. https://doi.org/10.1093/CLINCHEM/48.2.359
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