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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Jan-Willem Sels

Assistant Professor

Dr Jan-Willem Sels received his medical degree from the University of Utrecht in 2002. He started clinical work at the Catharina Hospital Eindhoven where he started his training in cardiology in 2004. During this training he obtained his PhD at the Technical University Eindhoven in 2013. His dissertation was entitled: ”Markers of inducible myocardial ischemia in the systemic circulation”. After completion of his training in cardiology, he was additionally trained as an intensivist at the Maastricht UMC+. He currently works as a cardiologist and cardiologist-intensivist at both the Cardiology and Intensive Care Medicine departments of Maastricht UMC+.

Dr Sels is mainly involved in clinical work and management in a way that fosters collaboration within in various research projects. The research focus is on improving clinical cardiovascular care for critically ill patients, including topics such as extracorporeal life support and optimizing hemostasis in critical care. Dr Sels will therefore participate within the HEMOSUM community platform. As state above, he is a team player that likes to involve students, junior physicians and nurses in bedside teaching and critical appraisal of clinical science. He thereby aims to translate relevant clinical issues into practical science to improve patient monitoring and support. Dr Sels will therefore operate mainly on projects within advanced monitoring care, while providing careful clinical assistance for the PI group’s big data projects. 

Jan willem sels

Departments of Cardiology and Intensive Care
T: +31(0)43 387 6543

  • 2024
    • Ghossein, M. A., de Kok, J. W. T. M., Eerenberg, F., van Rosmalen, F., Boereboom, R., Duisberg, F., Verharen, K., Sels, J. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., Meex, S. J. R., van Kuijk, S. M. J., van Stipdonk, A. M. W., Ghossein, C., Prinzen, F. W., van der Horst, I. C. C., Vernooy, K., van Bussel, B. C. T., & Driessen, R. G. H. (2024). Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort. Annals of Noninvasive Electrocardiology, 29(5), Article e70001. https://doi.org/10.1111/anec.70001
    • Cox, E. G. M., van Bussel, B. C. T., Llamazares, N. C., Sels, J.-W. E. M., Onrust, M., van der Horst, I. C. C., Koeze, J., & SICS Study Group (2024). Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study. Critical Care, 28(1), Article 106. https://doi.org/10.1186/s13054-024-04891-6
    • Hulshof, A. M., Nab, L., van Rosmalen, F., de Kok, J., Mulder, M. M. G., Hellenbrand, D., Sels, J. W. E. M., ten Cate, H., Cannegieter, S. C., Henskens, Y. M. C., & van Bussel, B. C. T. (2024). Rotational thromboelastometry as a biomarker for mortality — The Maastricht Intensive Care COVID cohort. Thrombosis Research, 234, 51-58. https://doi.org/10.1016/j.thromres.2023.12.010
    • de Kok, J. W. T. M., van Rosmalen, F., Koeze, J., Keus, F., van Kuijk, S. M. J., Castela Forte, J., Schnabel, R. M., Driessen, R. G. H., van Herpt, T. T. W., Sels, J.-W. E. M., Bergmans, D. C. J. J., Lexis, C. P. H., van Doorn, W. P. T. M., Meex, S. J. R., Xu, M., Borrat, X., Cavill, R., van der Horst, I. C. C., & van Bussel, B. C. T. (2024). Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts. Scientific Reports, 14(1), Article 1045. https://doi.org/10.1038/s41598-024-51699-z
    • Simons, J., Di Mauro, M., Mariani, S., Ravaux, J., van der Horst, I. C. C., Driessen, R. G. H., Sels, J. W., Delnoij, T., Brodie, D., Abrams, D., Mueller, T., Taccone, F. S., Belliato, M., Broman, M. L., Malfertheiner, M. V., Boeken, U., Fraser, J., Wiedemann, D., Belohlavek, J., ... Lorusso, R. (2024). Bilateral Femoral Cannulation Is Associated With Reduced Severe Limb Ischemia-Related Complications Compared With Unilateral Femoral Cannulation in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation: Results From the Extracorporeal Life Support Registry. Critical Care Medicine, 52(1), 80-91. https://doi.org/10.1097/CCM.0000000000006040
  • 2023
    • Mulder, M. M. G., Schellens, J., Sels, J.-W. E. M., van Rosmalen, F., Hulshof, A.-M., de Vries, F., Segers, R., Mihl, C., van Mook, W. N. K. A., Bast, A., Spronk, H. M. H., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Schurgers, L. J., Drent, M., & van Bussel, B. C. T. (2023). Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort. Journal of Intensive Care, 11(1), Article 63. https://doi.org/10.1186/s40560-023-00712-0
    • Schultinge, L., Hulshof, A. M., van Neerven, D., Mulder, M. M. G., Sels, J. W. E. M., Hulsewe, H. P. M. G., Kuiper, G. J. A. J. M., Olie, R. H., ten Cate, H., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2023). Applications of rotational thromboelastometry in heparin monitoring in critical COVID-19 disease: Observations in the Maastricht Intensive Care COVID cohort. Thrombosis Update, 12(1), Article 100140. https://doi.org/10.1016/j.tru.2023.100140
  • 2022
    • Denessen, E. J., Heuts, S., Daemen, J. H., van Doorn, W. P., Vroemen, W. H., Sels, J.-W., Segers, P., Van't Hof, A. W., Maessen, J. G., Bekers, O., Van Der Horst, I. C., & Mingels, A. M. (2022). High-Sensitivity Cardiac Troponin I and T Kinetics Differ following Coronary Bypass Surgery: A Systematic Review and Meta-Analysis. Clinical Chemistry, 68(12), 1564-1575. Article hvac152. https://doi.org/10.1093/clinchem/hvac152
    • Bol, M. E., Huckriede, J. B., van de Pas, K. G. H., Delhaas, T., Lorusso, R., Nicolaes, G. A. F., Sels, J. E. M., & van de Poll, M. C. G. (2022). Multimodal measurement of glycocalyx degradation during coronary artery bypass grafting. Frontiers in medicine, 9, 1045728. Article 1045728. https://doi.org/10.3389/fmed.2022.1045728
    • Bol, M. E., Broddin, B. E. K., Delhaas, T., Sels, J. E. M., & van de Poll, M. C. G. (2022). Variability of microcirculatory measurements in healthy volunteers. Scientific Reports, 12(1), Article 19887. https://doi.org/10.1038/s41598-022-22947-x
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in Cardiovascular Medicine, 9, Article 929284. https://doi.org/10.3389/fcvm.2022.929284
    • Ghossein, M. A., Driessen, R. G. H., van Rosmalen, F., Sels, J.-W. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., van Stipdonk, A. M. W., Prinzen, F. W., Ghossein-Doha, C., van Kuijk, S. M. J., van der Horst, I. C. C., Vernooy, K., & van Bussel, B. C. T. (2022). Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort). American Journal of Cardiology, 170, 118-127. https://doi.org/10.1016/j.amjcard.2022.01.030
    • Heuts, S., Denessen, E. J. S., Daemen, J. H. T., Vroemen, W. H. M., Sels, J. W., Segers, P., Bekers, O., Hof, A. W. J. V., Maessen, J. G., van der Horst, I. C. C., & Mingels, A. M. A. (2022). Meta-Analysis Evaluating High-Sensitivity Cardiac Troponin T Kinetics after Coronary Artery Bypass Grafting in Relation to the Current Definitions of Myocardial Infarction. American Journal of Cardiology, 163, 25-31. https://doi.org/10.1016/j.amjcard.2021.09.049
  • 2021
    • Heuts, S., Ubben, J. F., Banks-Gonzales, V., Sels, J.-W., Lorusso, R., van Mook, W. N. K. A., & Delnoij, T. S. R. (2021). Nitric Oxide Ventilation Improves Recirculation and Right Ventricular Function During Veno-Venous Extracorporeal Membrane Oxygenation in a COVID-19 Patient. Journal of Cardiothoracic and Vascular Anesthesia, 35(9), 2763-2767. https://doi.org/10.1053/j.jvca.2020.09.137
    • Huckriede, J., Anderberg, S. B., Morales, A., de Vries, F., Hultstrom, M., Bergqvist, A., Ortiz-Perez, J. T., Sels, J. W., Wichapong, K., Lipcsey, M., van de Poll, M., Larsson, A., Luther, T., Reutelingsperger, C., Garcia de Frutos, P., Frithiof, R., & Nicolaes, G. A. F. (2021). Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Scientific Reports, 11(1), Article 15701. https://doi.org/10.1038/s41598-021-95209-x
    • Hulshof, A. M., Braeken, D. C. W., Ghossein-Doha, C., van Santen, S., Sels, J. W. E. M., Kuiper, G. J. A. J. M., van der Horst, I. C. C., ten Cate, H., van Bussel, B. C. T., Olie, R. H., & Henskens, Y. M. C. (2021). Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge. Research and practice in thrombosis and haemostasis, 5(6), Article e12579. https://doi.org/10.1002/rth2.12579
    • Mulder, M. M. G., Brandts, LI., Brüggemann, R. A. G., Koelmann, M., Streng, A. S., Olie, R. H., Gietema, H. A., Spronk, H. M. H., van der Horst, I. C. C., Sels, J.-W. E. M., Wildberger, J. E., van Kuijk, S. M. J., Schnabel, R. M., Ten Cate, H., Henskens, Y. M. C., & van Bussel, B. C. T. (2021). Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort. Thrombosis Journal, 19(1), Article 35. https://doi.org/10.1186/s12959-021-00286-7
    • Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Weijs, B., Vernooy, K., Hartgerink, D. E. J., Jacobs, J. S., Erkuner, O., Marcks, N. G. H. M., van Cauteren, Y. J. M., Dinh, T., ter Bekke, R. M. A., Sels, J. E. M. W., Delnoij, T. S. R., Geyik, Z., Driessen, R. G. H., Linz, D. K., den Uijl, D. W., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2021). Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation. Netherlands Heart Journal, 29(5), 255-261. https://doi.org/10.1007/s12471-020-01528-5
    • Willers, A., Swol, J., Kowalewski, M., Raffa, G. M., Meani, P., Jiritano, F., Matteucci, M., Fina, D., Heuts, S., Bidar, E., Natour, E., Sels, J. W., Delnoij, T., & Lorusso, R. (2021). Extracorporeal Life Support in Hemorrhagic Conditions: A Systematic Review. Asaio Journal, 67(5), 476-484. https://doi.org/10.1097/mat.0000000000001216
    • van de Berg, T. W., Hulshof, A.-M. M., Nagy, M., van Oerle, R., Sels, J.-W., van Bussel, B., Ten Cate, H., Henskens, Y., Spronk, H. M. H., & Dutch Covid-19 and Thrombosis Coalition (2021). Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability. Thrombosis Research, 201, 84-89. https://doi.org/10.1016/j.thromres.2021.02.026
    • Hulshof, A.-M., Brüggemann, R. A. G., Mulder, M. M. G., van de Berg, T. W., Sels, J.-W. E. M., Olie, R. H., Spaetgens, B., Streng, A. S., Verhezen, P., van der Horst, I. C. C., Ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Henskens, Y. M. C. (2021). Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort-Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation. Frontiers in Cardiovascular Medicine, 8, Article 654174. https://doi.org/10.3389/fcvm.2021.654174
    • Kowalewski, M., Zielinski, K., Gozdek, M., Raffa, G. M., Pilato, M., Alanazi, M., Gilbers, M., Heuts, S., Natour, E., Bidar, E., Schreurs, R., Delnoij, T., Driessen, R., Sels, J. W., van de Poll, M., Roekaerts, P., Pasierski, M., Meani, P., Maessen, J., ... Lorusso, R. (2021). Veno-Arterial Extracorporeal Life Support in Heart Transplant and Ventricle Assist Device Centres. Meta-analysis. Esc heart failure, 8(2), 1064-1075. https://doi.org/10.1002/ehf2.13080
  • 2020
    • Schiffer, V. M. M. M., Janssen, E. B. N. J., van Bussel, B. C. T., Jorissen, L. L. M., Tas, J., Sels, J.-W. E. M., Bergmans, D. C. J. J., Dinh, T. H. T., van Kuijk, S. M. J., Hana, A., Mehagnoul-Schipper, J., Scheeren, C. I. E., Mesotten, D., Stessel, B., Marx, G., Hof, A. W. J. V. T., Spaanderman, M. E. A., van Mook, W. N. K. A., van der Horst, I. C. C., & Ghossein-Doha, C. (2020). The "sex gap" in COVID-19 trials: a scoping review. EClinicalMedicine, 29-30, Article 100652. https://doi.org/10.1016/j.eclinm.2020.100652
    • Streng, A. S., Delnoij, T. S. R., Mulder, M. M. G., Sels, J. W. E. M., Wetzels, R. J. H., Verhezen, P. W. M., Olie, R. H., Kooman, J. P., van Kuijk, S. M. J., Brandts, L., Ten Cate, H., Lorusso, R., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2020). Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO. TH open : companion journal to thrombosis and haemostasis, 4(4), e365-e375. https://doi.org/10.1055/s-0040-1719083
    • Bol, M. E., Beurskens, D. M. H., Delnoij, T. S. R., Roekaerts, P. M. H. J., Reutelingsperger, C. P. M., Delhaas, T., van de Poll, M. C. G., Sels, J.-W. E. M., & Nicolaes, G. A. F. (2020). Variability of Microcirculatory Measurements in Critically Ill Patients. Shock, 54(1), 9-14. https://doi.org/10.1097/SHK.0000000000001470
    • Beurskens, D. M. H., Bol, M. E., Delhaas, T., van de Poll, M. C. G., Reutelingsperger, C. P. M., Nicolaes, G. A. F., & Sels, J.-W. E. M. (2020). Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis. Anaesthesia and Intensive Care, 48(3), 221-228. https://doi.org/10.1177/0310057X20916471
    • Kowalewski, M., Raffa, G., Zielinski, K., Meani, P., Alanazi, M., Gilbers, M., Heuts, S., Natour, E., Bidar, E., Schreurs, R., Delnoij, T., Driessen, R., Sels, J. W., van de Poll, M., Roekaerts, P., Maessen, J., Suwalski, P., & Lorusso, R. (2020). Baseline surgical status and short-term mortality after extracorporeal membrane oxygenation for post-cardiotomy shock: a meta-analysis. Perfusion, 35(3), 246-254. Article 0267659119865122. https://doi.org/10.1177/0267659119865122
    • Kowalewski, M., Raffa, G. M., Zielinski, K., Alanazi, M., Gilbers, M., Heuts, S., Natour, E., Bidar, E., Schreurs, R., Delnoij, T., Driessen, R., Sels, J.-W., van de Poll, M., Roekaerts, P., Meani, P., Maessen, J., Suwalski, P., & Lorusso, R. (2020). The impact of Centre's heart transplant status and volume on in-hospital outcomes following extracorporeal membrane oxygenation for refractory post-cardiotomy cardiogenic shock: a meta-analysis. BMC Cardiovascular disorders, 20(1), Article 10. https://doi.org/10.1186/s12872-019-01317-y
    • Tas, J., van Gassel, R. J. J., Heines, S. J. H., Mulder, M. M. G., Heijnen, N. F. L., Acampo-de Jong, M. J., Bels, J. L. M., Bennis, F. C., Koelmann, M., Groven, R. V. M., Donkers, M. A., van Rosmalen, F., Hermans, B. J. M., Meex, S. J. R., Mingels, A., Bekers, O., Savelkoul, P., Oude Lashof, A. M. L., Wildberger, J., ... van Bussel, B. C. T. (2020). Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht). BMJ Open, 10(9), Article 040175. https://doi.org/10.1136/bmjopen-2020-040175
  • 2019
    • Meani, P., Delnoij, T., Raffa, G. M., Morici, N., Viola, G., Sacco, A., Oliva, F., Heuts, S., Sels, J.-W., Driessen, R., Roekaerts, P., Gilbers, M., Bidar, E., Schreurs, R., Natour, E., Veenstra, L., Kats, S., Maessen, J., & Lorusso, R. (2019). Protracted aortic valve closure during peripheral veno-arterial extracorporeal life support: is intra-aortic balloon pump an effective solution?Perfusion, 34(1), 35-41. https://doi.org/10.1177/0267659118787426
  • 2017
    • Keustermans, G. C., Kofink, D., Eikendal, A., de Jager, W., Meerding, J., Nuboer, R., Waltenberger, J., Kraaijeveld, A. O., Jukema, J. W., Sels, J. W., Garssen, J., Prakken, B. J., Asselbergs, F. W., Kalkhoven, E., Hoefer, I. E., Pasterkamp, G., & Schipper, H. S. (2017). Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults. Scientific Reports, 7(1), Article 16826. https://doi.org/10.1038/s41598-017-17195-3
    • Gietler, A., Pragt, E., Sels, J. W. E. M., Hannemann, P. F. W., Bouman, E. A., Bergmans, D. C. J. J., & van Mook, W. N. K. A. (2017). Coma and haemodynamic instability in the context of trauma. Netherlands Journal of Critical Care, 25(6), 210-214. https://www.njcc.nl/sites/nvic.nl/files/pdf/case-report_26.pdf
    • Raffa, G. M., Gelsomino, S., Sluijpers, N., Meani, P., Alenizy, K., Natour, E., Bidar, E., Johnson, D. M., Makhoul, M., Heuts, S., Lozekoot, P., Kats, S., Schreurs, R., Delnoij, T., Montalti, A., Sels, J. W., Poll, M. V. D., Roekaerts, P., Maessen, J., & Lorusso, R. (2017). In-hospital outcome of post-cardiotomy extracorporeal life support in adult patients: the 2007-2017 Maastricht experience. Critical Care and Resuscitation, 19(Suppl 1), 53-61. http://cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR%20Journal/Previous%20Editions/October%20Supplement%202017/ccr_19_OctSupp_011017-S53-S61.pdf
    • Meani, P., Gelsomino, S., Natour, E., Johnson, D. M., Rocca, H.-P. B. L., Pappalardo, F., Bidar, E., Makhoul, M., Raffa, G., Heuts, S., Lozekoot, P., Kats, S., Sluijpers, N., Schreurs, R., Delnoij, T., Montalti, A., Sels, J. W., van de Poll, M., Roekaerts, P., ... Lorusso, R. (2017). Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature. European journal of heart failure, 19 Suppl 2, 84-91. https://doi.org/10.1002/ejhf.850
  • 2016
    • Claes, G. R. F., van Tienen, F. H. J., Lindsey, P., Krapels, I. P. C., van den Enden, A., Hoos, M., Barrois, Y. E. G., Janssen, J., Paulussen, A. D. C., Sels, J.-W. E. M., Kuijpers, S. H. H., van Tintelen, J. P., van den Berg, M. P., Heesen, W. F., Garcia-Pavia, P., Perrot, A., Christiaans, I., Salemink, S., Marcelis, C. L. M., ... van den Wijngaard, A. (2016). Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers. European Heart Journal, 37(23), 1815-1822. https://doi.org/10.1093/eurheartj/ehv522
    • Rutten, B., Roest, M., McClellan, E. A., Sels, J. W., Stubbs, A., Jukema, J. W., Doevendans, P. A., Waltenberger, J., van Zonneveld, A.-J., Pasterkamp, G., de Groot, P. G., & Hoefer, I. E. (2016). Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention. Thrombosis and Haemostasis, 115(2), 353-360. https://doi.org/10.1160/TH15-03-0227
  • 2013
    • Hoefer, I. E., Sels, J.-W., Jukema, J. W., Bergheanu, S., Biessen, E., McClellan, E., Daemen, M., Doevendans, P., de Groot, P., Hillaert, M., Horsman, S., Ilhan, M., Kuiper, J., Pijls, N., Redekop, K., van der Spek, P., Stubbs, A., van de Veer, E., Waltenberger, J., ... Pasterkamp, G. (2013). Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the CIRCULATING CELLS study. Clinical research in cardiology, 102(11), 847-856. https://doi.org/10.1007/s00392-013-0607-9
Overview