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ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

20 August 2024

The project 'Impact of COVID-19 protective measures and shielding in vulnerable patients with kidney failure', coordinated by Prof. Marc Hemmelder and Drs Pim Bouwmans (Dept of Internal Medicine), has been granted by ZonMw. 

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Professorship Henri Spronk

Professorship Henri Spronk

12 August 2024

Dr Henri Spronk (Dept of Biochemistry) has been appointed as professor of ‘Biochemistry of Atherothrombosis’ as of 1 May 2024.

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Carim Maastricht
Carim Maastricht

Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Iwanvdhorst1

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2022
    • Ghossein-Doha, C., Wintjens, M. S. J. N., Janssen, E. B. N. J., Klein, D., Heemskerk, S. C. M., Asselbergs, F. W., Birnie, E., Bonsel, G. J., van Bussel, B. C. T., Cals, J. W. L., Ten Cate, H., Haagsma, J., Hemmen, B., van der Horst, I. C. C., Kietselaer, B. L. J. H., Klok, F. A., de Kruif, M. D., Linschoten, M., van Santen, S., ... van Kuijk, S. M. J. (2022). Prevalence, pathophysiology, prediction and health-related quality of life of long COVID: study protocol of the longitudinal multiple cohort CORona Follow Up (CORFU) study. BMJ Open, 12(11), Article e065142. https://doi.org/10.1136/bmjopen-2022-065142
    • Eck, R. J., van de Leur, J. J. C. M., Wiersema, R., Cox, E. G. M., Bult, W., Spanjersberg, A. J., van der Horst, I. C. C., Lukens, M. V., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Trough anti-Xa activity after intermediate dose nadroparin for thrombosis prophylaxis in critically ill patients with COVID-19 and acute kidney injury. Scientific Reports, 12(1), Article 17408. https://doi.org/10.1038/s41598-022-21560-2
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in Cardiovascular Medicine, 9, Article 929284. https://doi.org/10.3389/fcvm.2022.929284
    • Vos, M. E., Cox, E. G. M., Schagen, M. R., Hiemstra, B., Wong, A., Koeze, J., van der Horst, I. C. C., Wiersema, R., & SICS Study Group (2022). Right ventricular strain measurements in critically ill patients: an observational SICS sub-study. Annals of Intensive Care, 12(1), Article 92. https://doi.org/10.1186/s13613-022-01064-y
    • Ganushchak, Y. M., Kurniawati, E. R., van der Horst, I. C. C., van Kuijk, S. M. J., Weerwind, P. W., Lorusso, R., & Maessen, J. G. (2022). Patterns of oxygen debt repayment in cardiogenic shock patients sustained with extracorporeal life support: A retrospective study. Journal of Critical Care, 71, Article 154044. https://doi.org/10.1016/j.jcrc.2022.154044
    • Wolbrink, D. R. J., van de Poll, M. C. G., Termorshuizen, F., de Keizer, N. F., van der Horst, I. C. C., Schnabel, R., Dejong, C. H. C., van Santvoort, H. C., Besselink, M. G., van Goor, H., Bouwense, S. A. W., van Bussel, B. C. T., Dutch Pancreatitis Study Group, & Dutch National Intensive Care Evaluation (NICE) Collaborators (2022). Trends in Early and Late Mortality in Patients With Severe Acute Pancreatitis Admitted to ICUs: A Nationwide Cohort Study. Critical Care Medicine, 50(10), 1513-1521. https://doi.org/10.1097/CCM.0000000000005629
    • van der Horst, I. C. C. (2022). Forecast with eyes wide open – a perspective on the upcoming winter. Netherlands Journal of Critical Care, 30(5), 150-151. https://de-intensivist.nl/forecast-with-eyes-wide-open-a-perspective-on-the-upcoming-winter/
    • Tas, J., Bos, K. D. J., le Feber, J., Beqiri, E., Czosnyka, M., Haeren, R., van der Horst, I. C. C., van Kuijk, S. M. J., Strauch, U., Brady, K. M., Smielewski, P., & Aries, M. J. H. (2022). Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury. Journal of Applied Physiology, 133(3), 585-592. https://doi.org/10.1152/japplphysiol.00199.2022
    • Heines, S. J. H., van Bussel, B. C. T., Jong, M. J. A., Bennis, F. C., van Gassel, R. J. J., Groven, R. V. M., Heijnen, N. F. L., Hermans, B. J. M., Hounjet, R., van Koll, J., Mulder, M. M. G., van de Poll, M. C. G., van Rosmalen, F., Segers, R., Steyns, S., Strauch, U., Tas, J., van der Horst, I. C. C., van Kuijk, S. M. J., & Bergmans, D. C. J. J. (2022). Pulmonary pathophysiology development of COVID-19 assessed by serial Electrical Impedance Tomography in the MaastrICCht cohort. Scientific Reports, 12(1), Article 14517. https://doi.org/10.1038/s41598-022-18843-z
    • Heines, S. J. H., de Jongh, S. A. M., Strauch, U., van der Horst, I. C. C., van de Poll, M. C. G., & Bergmans, D. C. J. J. (2022). The global inhomogeneity index assessed by electrical impedance tomography overestimates PEEP requirement in patients with ARDS: an observational study. BMC Anesthesiology, 22(1), Article 258. https://doi.org/10.1186/s12871-022-01801-7
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., Soultana, O., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... van Royen, N. (2022). Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis. European Heart Journal: Acute Cardiovascular Care, 11(7), 535-543. https://doi.org/10.1093/ehjacc/zuac060
    • Eck, R. J., Elling, T., Sutton, A. J., Wetterslev, J., Gluud, C., van der Horst, I. C. C., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis. BMJ, 378, Article e070022. https://doi.org/10.1136/bmj-2022-070022
    • Tas, J., Eleveld, N., Borg, M., Bos, K. D. J., Langermans, A. P., van Kuijk, S. M. J., van der Horst, I. C. C., Elting, J. W. J., & Aries, M. J. H. (2022). Cerebral Autoregulation Assessment Using the Near Infrared Spectroscopy 'NIRS-Only' High Frequency Methodology in Critically Ill Patients: A Prospective Cross-Sectional Study. Cells, 11(14), Article 2254. https://doi.org/10.3390/cells11142254
    • Raafs, A. G., Ghossein, M. A., Brandt, Y., Henkens, M. T. H. M., Kooi, M. E., Vernooy, K., Spaanderman, M. E. A., Gerretsen, S., van Santen, S., Driessen, R. G. H., Knackstedt, C., van der Horst, I. C. C., van Bussel, B. C. T., Heymans, S. R. B., Ghossein-Doha, C., & MaastrICCht Collaborators (2022). Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection. Journal of Hypertension, 40(7), 1278-1287. https://doi.org/10.1097/hjh.0000000000003110
    • Martens, B., Driessen, R. G. H., Brandts, L., Hoitinga, P., van Veen, F., Driessen, M., Weberndörfer, V., Kietselaer, B., Ghossein-Doha, C., Gietema, H. A., Vernooy, K., van der Horst, I. C. C., Wildberger, J. E., van Bussel, B. C. T., Mihl, C., & MaastrICCht Collaborators (2022). Coronary Artery Calcifications Are Associated With More Severe Multiorgan Failure in Patients With Severe Coronavirus Disease 2019 Infection: Longitudinal Results of the Maastricht Intensive Care COVID Cohort. Journal of Thoracic Imaging, 37(4), 217-224. https://doi.org/10.1097/RTI.0000000000000648
    • Cuijpers, A. C. M., Coolsen, M. M. E., Schnabel, R. M., Lubbers, T., van der Horst, I. C. C., van Santen, S., Damink, S. W. M. O., & van de Poll, M. C. G. (2022). Self-perceived recovery and quality of life in elderly patients surviving ICU-admission for abdominal sepsis. Journal of Intensive Care Medicine, 37(7), 970-978. Article 08850666211052460. https://doi.org/10.1177/08850666211052460
    • Mariani, S., De Piero, M. E., Ravaux, J. M., Saelmans, A., Kawczynski, M. J., van Bussel, B. C. T., Di Mauro, M., Willers, A., Swol, J., Kowalewski, M., Li, T., Delnoij, T. S. R., van der Horst, I. C. C., Maessen, J., & Lorusso, R. (2022). Temporary mechanical circulatory support for COVID-19 patients: A systematic review of literature. Artificial Organs, 46(7), 1249-1267. https://doi.org/10.1111/aor.14261
    • Cox, E. G. M., Koeze, J., van der Horst, I. C. C., & Wiersema, R. (2022). Calculated left ventricular outflow tract diameter for critically ill patients. Journal of Intensive Care, 10(1), Article 31. https://doi.org/10.1186/s40560-022-00623-6
    • Reijrink, M., van Ark, J., Lexis, C. P. H., Visser, L. M., Lodewijk, M. E., van der Horst, I. C. C., Zeebregts, C. J., van Goor, H., de Jager, S. C. A., Pasterkamp, G., Wolffenbuttel, B. H. R., & Hillebrands, J. L. (2022). Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus. Cardiovascular Diabetology, 21(1), Article 72. https://doi.org/10.1186/s12933-022-01497-6
    • Ghossein, M. A., Driessen, R. G. H., van Rosmalen, F., Sels, J.-W. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., van Stipdonk, A. M. W., Prinzen, F. W., Ghossein-Doha, C., van Kuijk, S. M. J., van der Horst, I. C. C., Vernooy, K., & van Bussel, B. C. T. (2022). Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort). American Journal of Cardiology, 170, 118-127. https://doi.org/10.1016/j.amjcard.2022.01.030
    • van Herpt, T. T. W., Timmermans, S. A. M. E. G., van Mook, W. N. K. A., van Bussel, B. C. T., van der Horst, I. C. C., Maessen, J. G., Natour, E., van Paassen, P., & Heuts, S. (2022). Postsurgical Thrombotic Microangiopathy and Deregulated Complement. Journal of Clinical Medicine, 11(9), Article 2501. https://doi.org/10.3390/jcm11092501
    • Mesotten, D., Meijs, D. A. M., van Bussel, B. C. T., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Strauch, U., van de Poll, M. C. G., Ghossein-Doha, C., Buhre, W. F. F. A., Bickenbach, J., Vander Laenen, M., Marx, G., van der Horst, I. C. C., & COVID Data Platform (CoDaP) Investigators (2022). Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort Study. Critical Care Medicine, 50(4), 595-606. https://doi.org/10.1097/CCM.0000000000005314
    • Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., ... Raafs, A. (2022). Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries. European Heart Journal, 43(11), 1104-1120. https://doi.org/10.1093/eurheartj/ehab656
    • Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., Ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., Heymans, S. R. B., & CAPACITY-COVID collaborative consortium (2022). Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. BMC Geriatrics, 22(1), Article 184. https://doi.org/10.1186/s12877-021-02673-1
    • Camaro, C., Bonnes, J. L., Adang, E. M., Spoormans, E. M., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J., van der Harst, P., van der Horst, I. C., Voskuil, M., ... van Royen, N. (2022). Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest. Journal of the American Heart Association, 11(5), Article e022238. https://doi.org/10.1161/JAHA.121.022238
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., Girbes, A. R. J., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... Elbers, P. W. G. (2022). Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial. Critical Care Medicine, 50(2), e129-e142. https://doi.org/10.1097/CCM.0000000000005271
    • Heuts, S., Denessen, E. J. S., Daemen, J. H. T., Vroemen, W. H. M., Sels, J. W., Segers, P., Bekers, O., Hof, A. W. J. V., Maessen, J. G., van der Horst, I. C. C., & Mingels, A. M. A. (2022). Meta-Analysis Evaluating High-Sensitivity Cardiac Troponin T Kinetics after Coronary Artery Bypass Grafting in Relation to the Current Definitions of Myocardial Infarction. American Journal of Cardiology, 163, 25-31. https://doi.org/10.1016/j.amjcard.2021.09.049
    • Meijs, D. A. M., van Bussel, B. C. T., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Peters, S. A. E., van Mook, W. N. K. A., van der Horst, I. C. C., Marx, G., Mesotten, D., Ghossein-Doha, C., CoDaP Investigators, Heijnen, N. F. L., Raafs, A., van Kuijk, S. M. J., Smits, L. J. M., Janssen, E. B. N. J., Mulder, M. M. G., ... Florack, M. C. D. M. (2022). Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment. Scientific Reports, 12(1), Article 734. https://doi.org/10.1038/s41598-021-04531-x
    • Heijnen, N. F. L., Hagens, L. A., van Schooten, F.-J., Bos, L. D. J., van der Horst, I. C. C., Mommers, A., Schultz, M. J., Smit, M. R., Bergmans, D. C. J. J., Smolinska, A., & Schnabel, R. M. (2022). Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia. ERJ Open Research, 8(1), Article 00624-2021. https://doi.org/10.1183/23120541.00624-2021
    • Heuts, S., van der Horst, I. C. C., & Mingels, A. (2022). Towards an improved definition of periprocedural myocardial infarction: The role of high-sensitivity cardiac troponins. Journal of Cardiac Surgery, 37(1), 162-164. https://doi.org/10.1111/jocs.16107
  • 2021
    • Amer, A. Y. A., Wouters, F., Vranken, J., Dreesen, P., Boer, D. D., van Rosmalen, F., van Bussel, B. C. T., Smit-Fun, V., Duflot, P., Guiot, J., van der Horst, I. C. C., Mesotten, D., Vandervoort, P., Aerts, J. M., & Vanrumste, B. (2021). Vital Signs Prediction for COVID-19 Patients in ICU. Sensors, 21(23), Article 8131. https://doi.org/10.3390/s21238131
    • Cox, E. G. M., Onrust, M., Vos, M. E., Paans, W., Dieperink, W., Koeze, J., van der Horst, I. C. C., Wiersema, R., SICS Study Group, & SOCCS Student Team (2021). The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality. Critical Care, 25(1), Article 393. https://doi.org/10.1186/s13054-021-03809-w
    • Driessen, R. G. H., Groven, R. V. M., van Koll, J., Oudhuis, G. J., Posthouwer, D., van der Horst, I. C. C., Bergmans, D. C. J. J., & Schnabel, R. M. (2021). Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU. Infectious Diseases, 53(11), 830-838. https://doi.org/10.1080/23744235.2021.1942543
    • Strauch, U., Florack, M. C. D. M., Jansen, J., van Bussel, B. C. T., Beckers, S. K., Habers, J., Winkens, B., van der Horst, I. C. C., van Mook, W. N. K. A., & Bergmans, D. C. J. J. (2021). The QUality of Interhospital Transportation in the Euregion Meuse-Rhine (QUIT-EMR) score: a cross-validation study. BMJ Open, 11(11), Article e051100. https://doi.org/10.1136/bmjopen-2021-051100
    • Tas, J., Beqiri, E., van Kaam, R. C., Czosnyka, M., Donnelly, J., Haeren, R. H., van der Horst, I. C. C., Hutchinson, P. J., van Kuijk, S. M. J., Liberti, A. L., Menon, D. K., Hoedemaekers, C. W. E., Depreitere, B., Smielewski, P., Meyfroidt, G., Ercole, A., & Aries, M. J. H. (2021). Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial. Journal of Neurotrauma, 38(20), 2790-2800. https://doi.org/10.1089/neu.2021.0197
    • van Gassel, R. J. J., Bels, J., Remij, L., van Bussel, B. C. T., Posthuma, R., Gietema, H. A., Verbunt, J., van der Horst, I. C. C., Damink, S. W. M. O., van Santen, S., & van de Poll, M. C. G. (2021). Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study. Critical Care Medicine, 49(10), 1726-1738. https://doi.org/10.1097/CCM.0000000000005089
    • Boekel, M. F., Venema, C. S., Kaufmann, T., van der Horst, I. C. C., Vos, J. J., & Scheeren, T. W. L. (2021). The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study. Journal of Clinical Monitoring and Computing, 35(5), 1193-1202. https://doi.org/10.1007/s10877-020-00585-w
    • Hulshof, A. M., Braeken, D. C. W., Ghossein-Doha, C., van Santen, S., Sels, J. W. E. M., Kuiper, G. J. A. J. M., van der Horst, I. C. C., ten Cate, H., van Bussel, B. C. T., Olie, R. H., & Henskens, Y. M. C. (2021). Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge. Research and practice in thrombosis and haemostasis, 5(6), Article e12579. https://doi.org/10.1002/rth2.12579
    • Beldhuis, I. E., Marapin, R. S., Jiang, Y. Y., de Souza, N. F. S., Georgiou, A., Kaufmann, T., Forte, J. C., & van der Horst, I. C. C. (2021). Cognitive biases, environmental, patient and personal factors associated with critical care decision making: A scoping review. Journal of Critical Care, 64, 144-153. https://doi.org/10.1016/j.jcrc.2021.04.012
    • Kurniawati, E. R., Rutjens, V. G. H., Vranken, N. P. A., Delnoij, T. S. R., Lorusso, R., van der Horst, I. C. C., Maessen, J. G., & Weerwind, P. W. (2021). Quality of life following adult veno-venous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review. Quality of Life Research, 30(8), 2123-2135. https://doi.org/10.1007/s11136-021-02834-0
    • Forte, C., Voinea, A., Chichirau, M., Yeshmagambetova, G., Albrecht, L. M., Erfurt, C., Freundt, L. A., Carmo, L. O. E., Henning, R. H., van der Horst, I. C. C., Sundelin, T., Wiering, M. A., Axelsson, J., & Epema, A. H. (2021). Deep Learning for Identification of Acute Illness and Facial Cues of Illness. Frontiers in medicine, 8, Article 661309. https://doi.org/10.3389/fmed.2021.661309
    • Barbateskovic, M., Koster, T. M., Eck, R. J., Maagaard, M., Afshari, A., Blokzijl, F., Cronhjort, M., Dieperink, W., Fabritius, M. L., Feinberg, J., French, C., Gareb, B., Geisler, A., Granholm, A., Hiemstra, B., Hu, R. X., Imberger, G., Jensen, B. T., Jonsson, A. B., ... Wetterslev, J. (2021). A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions. Journal of Clinical Epidemiology, 135, 29-41. https://doi.org/10.1016/j.jclinepi.2021.01.023
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), Article BSR20210954. https://doi.org/10.1042/BSR20210954
    • Lemkes, J. S., Spoormans, E. M., Demirkiran, A., Leutscher, S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., ... van Royen, N. (2021). The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial. Resuscitation, 164, 93-100. https://doi.org/10.1016/j.resuscitation.2021.04.020
    • Donkers, M. A., Gilissen, V. J. H. S., Candel, M. J. J. M., van Dijk, N. M., Kling, H., Heijnen-Panis, R., Pragt, E., van der Horst, I., Pronk, S. A., & van Mook, W. N. K. A. (2021). Moral distress and ethical climate in intensive care medicine during COVID-19: a nationwide study. BMC Medical Ethics, 22(1), Article 73. https://doi.org/10.1186/s12910-021-00641-3
    • Heijnen, N. F. L., Hagens, L. A., Smit, M. R., Cremer, O. L., Ong, D. S. Y., van der Poll, T., van Vught, L. A., Scicluna, B. P., Schnabel, R. M., van der Horst, I. C. C., Schultz, M. J., Bergmans, D. C. J. J., Bos, L. D. J., & MARD Consortium (2021). Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 203(12), 1503-1511. https://doi.org/10.1164/rccm.202006-2522OC
    • Forte, J. C., Yeshmagambetova, G., van der Grinten, M. L., Hiemstra, B., Kaufmann, T., Eck, R. J., Keus, F., Epema, A. H., Wiering, M. A., & van der Horst, I. C. C. (2021). Identifying and characterizing high-risk clusters in a heterogeneous ICU population with deep embedded clustering. Scientific Reports, 11(1), Article 12109. https://doi.org/10.1038/s41598-021-91297-x
    • Blokzijl, F., Onrust, M., Dieperink, W., Keus, F., van der Horst, I. C. C., Paans, W., Mariani, M. A., & Reneman, M. F. (2021). Barriers That Obstruct Return to Work After Coronary Bypass Surgery: A Qualitative Study. Journal of Occupational Rehabilitation, 31(2), 316-322. https://doi.org/10.1007/s10926-020-09919-6
    • Driessen, R. G. H., Latten, B. G. H., Bergmans, D. C. J. J., Hulsewe, R. P. M. G., Holtkamp, J. W. M., van der Horst, I. C. C., Kubat, B., & Schnabel, R. M. (2021). Clinical diagnoses vs. autopsy findings in early deceased septic patients in the intensive care: a retrospective cohort study. Virchows Archiv, 478(6), 1173-1178. https://doi.org/10.1007/s00428-020-02984-5
    • Bosveld, M. H., van Doorn, D. P. C., Stassen, P. M., Westerman, D., Bergmans, D. C. J. J., van der Horst, I. C. C., & van Mook, W. N. K. A. (2021). Lessons learned: Contribution to healthcare by medical students during COVID-19. Journal of Critical Care, 63, 113-116. https://doi.org/10.1016/j.jcrc.2020.09.015
Overview