Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2023
    • Kendall, H. J., van Kuijk, S. M., van der Horst, I. C., Dings, J. T., Aries, M. J., & Haeren, R. H. (2023). Difference between brain temperature and core temperature in severe traumatic brain injury: a systematic review. Journal of Neurosurgical Sciences, 67(1), 46-54. https://doi.org/10.23736/S0390-5616.21.05519-3
    • Al Ali, L., Groot, H. E., Assa, S., Lipsic, E., Hummel, Y. M., van Veldhuisen, D. J., Voors, A. A., van der Horst, I. C. C., Lam, C. S., & van der Harst, P. (2023). Predictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction. BMC Cardiovascular disorders, 23(1), Article 44. https://doi.org/10.1186/s12872-023-03064-7
    • Heuts, S., Gollmann-Tepeköylü, C., Denessen, E. J. S., Olsthoorn, J. R., Romeo, J. L. R., Maessen, J. G., van 't Hof, A. W. J., Bekers, O., Hammarsten, O., Pölzl, L., Holfeld, J., Bonaros, N., van der Horst, I. C. C., Davidson, S. M., Thielmann, M., & Mingels, A. M. A. (2023). Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications. European Heart Journal, 44(2), 100-112. https://doi.org/10.1093/eurheartj/ehac604
    • de Jongh, S. A. M., Heines, S. J. H., de Jongh, F. H. C., Segers, R. P. J., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2023). Regional peak flow as a novel approach to assess regional pulmonary mechanics by electrical impedance tomography: an observational validation study. Annals of translational medicine. Advance online publication. https://doi.org/10.21037/atm-22-3420
    • Volbeda, M., Oord, M., Koeze, J., Keus, E., van der Horst, I. C. C., & Franssen, C. F. M. (2023). Criteria for Continuous Kidney Replacement Therapy Cessation in ICU Patients. Blood Purification, 52(1), 32-40. https://doi.org/10.1159/000524180
    • Cox, E. G. M., Wiersema, R., Eck, R. J., Kaufmann, T., Granholm, A., Vaara, S. T., Møller, M. H., van Bussel, B. C. T., Snieder, H., Pleijhuis, R. G., van der Horst, I. C. C., & Keus, F. (2023). External Validation of Mortality Prediction Models for Critical Illness Reveals Preserved Discrimination but Poor Calibration. Critical Care Medicine, 51(1), 80-90. https://doi.org/10.1097/CCM.0000000000005712
  • 2022
    • Denessen, E. J., Heuts, S., Daemen, J. H., van Doorn, W. P., Vroemen, W. H., Sels, J.-W., Segers, P., Van't Hof, A. W., Maessen, J. G., Bekers, O., Van Der Horst, I. C., & Mingels, A. M. (2022). High-Sensitivity Cardiac Troponin I and T Kinetics Differ following Coronary Bypass Surgery: A Systematic Review and Meta-Analysis. Clinical Chemistry, 68(12), 1564-1575. Article hvac152. https://doi.org/10.1093/clinchem/hvac152
    • Tas, J., Czosnyka, M., van der Horst, I. C. C., Park, S., van Heugten, C., Sekhon, M., Robba, C., Menon, D. K., Zeiler, F. A., & Aries, M. J. H. (2022). Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury: A narrative review. Frontiers in physiology, 13, Article 1071161. https://doi.org/10.3389/fphys.2022.1071161
    • Meijs, D. A. M., van Kuijk, S. M. J., Wynants, L., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Bergmans, D. C. J. J., Bickenbach, J., Vander Laenen, M., Smits, L. J. M., van der Horst, I. C. C., Marx, G., Mesotten, D., van Bussel, B. C. T., CoDaP Investigators, Mulder, M., Bels, J., Wilmes, N., ... Ghossein, C. (2022). Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort. Journal of Clinical Epidemiology, 152, 257-268. https://doi.org/10.1016/j.jclinepi.2022.10.015
    • Ghossein-Doha, C., Wintjens, M. S. J. N., Janssen, E. B. N. J., Klein, D., Heemskerk, S. C. M., Asselbergs, F. W., Birnie, E., Bonsel, G. J., van Bussel, B. C. T., Cals, J. W. L., Ten Cate, H., Haagsma, J., Hemmen, B., van der Horst, I. C. C., Kietselaer, B. L. J. H., Klok, F. A., de Kruif, M. D., Linschoten, M., van Santen, S., ... van Kuijk, S. M. J. (2022). Prevalence, pathophysiology, prediction and health-related quality of life of long COVID: study protocol of the longitudinal multiple cohort CORona Follow Up (CORFU) study. BMJ Open, 12(11), Article e065142. https://doi.org/10.1136/bmjopen-2022-065142
    • Eck, R. J., van de Leur, J. J. C. M., Wiersema, R., Cox, E. G. M., Bult, W., Spanjersberg, A. J., van der Horst, I. C. C., Lukens, M. V., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Trough anti-Xa activity after intermediate dose nadroparin for thrombosis prophylaxis in critically ill patients with COVID-19 and acute kidney injury. Scientific Reports, 12(1), Article 17408. https://doi.org/10.1038/s41598-022-21560-2
    • van de Berg, T. W., Mulder, M. M. G., Alnima, T., Nagy, M., van Oerle, R., Beckers, E. A. M., Hackeng, T. M., Hulshof, A. M., Sels, J. W. E. M., Henskens, Y. M. C., van der Horst, I. C. C., ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Dutch COVID & Thrombosis Coalition (2022). Serial thrombin generation and exploration of alternative anticoagulants in critically ill COVID-19 patients: Observations from Maastricht Intensive Care COVID Cohort. Frontiers in Cardiovascular Medicine, 9, Article 929284. https://doi.org/10.3389/fcvm.2022.929284
    • Vos, M. E., Cox, E. G. M., Schagen, M. R., Hiemstra, B., Wong, A., Koeze, J., van der Horst, I. C. C., Wiersema, R., & SICS Study Group (2022). Right ventricular strain measurements in critically ill patients: an observational SICS sub-study. Annals of Intensive Care, 12(1), Article 92. https://doi.org/10.1186/s13613-022-01064-y
    • Ganushchak, Y. M., Kurniawati, E. R., van der Horst, I. C. C., van Kuijk, S. M. J., Weerwind, P. W., Lorusso, R., & Maessen, J. G. (2022). Patterns of oxygen debt repayment in cardiogenic shock patients sustained with extracorporeal life support: A retrospective study. Journal of Critical Care, 71, Article 154044. https://doi.org/10.1016/j.jcrc.2022.154044
    • Wolbrink, D. R. J., van de Poll, M. C. G., Termorshuizen, F., de Keizer, N. F., van der Horst, I. C. C., Schnabel, R., Dejong, C. H. C., van Santvoort, H. C., Besselink, M. G., van Goor, H., Bouwense, S. A. W., van Bussel, B. C. T., Dutch Pancreatitis Study Group, & Dutch National Intensive Care Evaluation (NICE) Collaborators (2022). Trends in Early and Late Mortality in Patients With Severe Acute Pancreatitis Admitted to ICUs: A Nationwide Cohort Study. Critical Care Medicine, 50(10), 1513-1521. https://doi.org/10.1097/CCM.0000000000005629
    • van der Horst, I. C. C. (2022). Forecast with eyes wide open – a perspective on the upcoming winter. Netherlands Journal of Critical Care, 30(5), 150-151. https://de-intensivist.nl/forecast-with-eyes-wide-open-a-perspective-on-the-upcoming-winter/
    • Tas, J., Bos, K. D. J., le Feber, J., Beqiri, E., Czosnyka, M., Haeren, R., van der Horst, I. C. C., van Kuijk, S. M. J., Strauch, U., Brady, K. M., Smielewski, P., & Aries, M. J. H. (2022). Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury. Journal of Applied Physiology, 133(3), 585-592. https://doi.org/10.1152/japplphysiol.00199.2022
    • Heines, S. J. H., van Bussel, B. C. T., Jong, M. J. A., Bennis, F. C., van Gassel, R. J. J., Groven, R. V. M., Heijnen, N. F. L., Hermans, B. J. M., Hounjet, R., van Koll, J., Mulder, M. M. G., van de Poll, M. C. G., van Rosmalen, F., Segers, R., Steyns, S., Strauch, U., Tas, J., van der Horst, I. C. C., van Kuijk, S. M. J., & Bergmans, D. C. J. J. (2022). Pulmonary pathophysiology development of COVID-19 assessed by serial Electrical Impedance Tomography in the MaastrICCht cohort. Scientific Reports, 12(1), Article 14517. https://doi.org/10.1038/s41598-022-18843-z
    • Heines, S. J. H., de Jongh, S. A. M., Strauch, U., van der Horst, I. C. C., van de Poll, M. C. G., & Bergmans, D. C. J. J. (2022). The global inhomogeneity index assessed by electrical impedance tomography overestimates PEEP requirement in patients with ARDS: an observational study. BMC Anesthesiology, 22(1), Article 258. https://doi.org/10.1186/s12871-022-01801-7
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., Soultana, O., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... van Royen, N. (2022). Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis. European Heart Journal: Acute Cardiovascular Care, 11(7), 535-543. https://doi.org/10.1093/ehjacc/zuac060
    • Eck, R. J., Elling, T., Sutton, A. J., Wetterslev, J., Gluud, C., van der Horst, I. C. C., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis. BMJ, 378, Article e070022. https://doi.org/10.1136/bmj-2022-070022
    • Tas, J., Eleveld, N., Borg, M., Bos, K. D. J., Langermans, A. P., van Kuijk, S. M. J., van der Horst, I. C. C., Elting, J. W. J., & Aries, M. J. H. (2022). Cerebral Autoregulation Assessment Using the Near Infrared Spectroscopy 'NIRS-Only' High Frequency Methodology in Critically Ill Patients: A Prospective Cross-Sectional Study. Cells, 11(14), Article 2254. https://doi.org/10.3390/cells11142254
    • Raafs, A. G., Ghossein, M. A., Brandt, Y., Henkens, M. T. H. M., Kooi, M. E., Vernooy, K., Spaanderman, M. E. A., Gerretsen, S., van Santen, S., Driessen, R. G. H., Knackstedt, C., van der Horst, I. C. C., van Bussel, B. C. T., Heymans, S. R. B., Ghossein-Doha, C., & MaastrICCht Collaborators (2022). Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection. Journal of Hypertension, 40(7), 1278-1287. https://doi.org/10.1097/hjh.0000000000003110
    • Martens, B., Driessen, R. G. H., Brandts, L., Hoitinga, P., van Veen, F., Driessen, M., Weberndörfer, V., Kietselaer, B., Ghossein-Doha, C., Gietema, H. A., Vernooy, K., van der Horst, I. C. C., Wildberger, J. E., van Bussel, B. C. T., Mihl, C., & MaastrICCht Collaborators (2022). Coronary Artery Calcifications Are Associated With More Severe Multiorgan Failure in Patients With Severe Coronavirus Disease 2019 Infection: Longitudinal Results of the Maastricht Intensive Care COVID Cohort. Journal of Thoracic Imaging, 37(4), 217-224. https://doi.org/10.1097/RTI.0000000000000648
    • Cuijpers, A. C. M., Coolsen, M. M. E., Schnabel, R. M., Lubbers, T., van der Horst, I. C. C., van Santen, S., Damink, S. W. M. O., & van de Poll, M. C. G. (2022). Self-perceived recovery and quality of life in elderly patients surviving ICU-admission for abdominal sepsis. Journal of Intensive Care Medicine, 37(7), 970-978. Article 08850666211052460. https://doi.org/10.1177/08850666211052460
    • Mariani, S., De Piero, M. E., Ravaux, J. M., Saelmans, A., Kawczynski, M. J., van Bussel, B. C. T., Di Mauro, M., Willers, A., Swol, J., Kowalewski, M., Li, T., Delnoij, T. S. R., van der Horst, I. C. C., Maessen, J., & Lorusso, R. (2022). Temporary mechanical circulatory support for COVID-19 patients: A systematic review of literature. Artificial Organs, 46(7), 1249-1267. https://doi.org/10.1111/aor.14261
    • Cox, E. G. M., Koeze, J., van der Horst, I. C. C., & Wiersema, R. (2022). Calculated left ventricular outflow tract diameter for critically ill patients. Journal of Intensive Care, 10(1), Article 31. https://doi.org/10.1186/s40560-022-00623-6
    • Reijrink, M., van Ark, J., Lexis, C. P. H., Visser, L. M., Lodewijk, M. E., van der Horst, I. C. C., Zeebregts, C. J., van Goor, H., de Jager, S. C. A., Pasterkamp, G., Wolffenbuttel, B. H. R., & Hillebrands, J. L. (2022). Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus. Cardiovascular Diabetology, 21(1), Article 72. https://doi.org/10.1186/s12933-022-01497-6
    • Ghossein, M. A., Driessen, R. G. H., van Rosmalen, F., Sels, J.-W. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., van Stipdonk, A. M. W., Prinzen, F. W., Ghossein-Doha, C., van Kuijk, S. M. J., van der Horst, I. C. C., Vernooy, K., & van Bussel, B. C. T. (2022). Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort). American Journal of Cardiology, 170, 118-127. https://doi.org/10.1016/j.amjcard.2022.01.030
    • van Herpt, T. T. W., Timmermans, S. A. M. E. G., van Mook, W. N. K. A., van Bussel, B. C. T., van der Horst, I. C. C., Maessen, J. G., Natour, E., van Paassen, P., & Heuts, S. (2022). Postsurgical Thrombotic Microangiopathy and Deregulated Complement. Journal of Clinical Medicine, 11(9), Article 2501. https://doi.org/10.3390/jcm11092501
    • Mesotten, D., Meijs, D. A. M., van Bussel, B. C. T., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Strauch, U., van de Poll, M. C. G., Ghossein-Doha, C., Buhre, W. F. F. A., Bickenbach, J., Vander Laenen, M., Marx, G., van der Horst, I. C. C., & COVID Data Platform (CoDaP) Investigators (2022). Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort Study. Critical Care Medicine, 50(4), 595-606. https://doi.org/10.1097/CCM.0000000000005314
    • Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., ... Raafs, A. (2022). Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries. European Heart Journal, 43(11), 1104-1120. https://doi.org/10.1093/eurheartj/ehab656
    • Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., Ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., Heymans, S. R. B., & CAPACITY-COVID collaborative consortium (2022). Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. BMC Geriatrics, 22(1), Article 184. https://doi.org/10.1186/s12877-021-02673-1
    • Camaro, C., Bonnes, J. L., Adang, E. M., Spoormans, E. M., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J., van der Harst, P., van der Horst, I. C., Voskuil, M., ... van Royen, N. (2022). Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest. Journal of the American Heart Association, 11(5), Article e022238. https://doi.org/10.1161/JAHA.121.022238
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., Girbes, A. R. J., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... Elbers, P. W. G. (2022). Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial. Critical Care Medicine, 50(2), e129-e142. https://doi.org/10.1097/CCM.0000000000005271
    • Heuts, S., Denessen, E. J. S., Daemen, J. H. T., Vroemen, W. H. M., Sels, J. W., Segers, P., Bekers, O., Hof, A. W. J. V., Maessen, J. G., van der Horst, I. C. C., & Mingels, A. M. A. (2022). Meta-Analysis Evaluating High-Sensitivity Cardiac Troponin T Kinetics after Coronary Artery Bypass Grafting in Relation to the Current Definitions of Myocardial Infarction. American Journal of Cardiology, 163, 25-31. https://doi.org/10.1016/j.amjcard.2021.09.049
    • Meijs, D. A. M., van Bussel, B. C. T., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Peters, S. A. E., van Mook, W. N. K. A., van der Horst, I. C. C., Marx, G., Mesotten, D., Ghossein-Doha, C., CoDaP Investigators, Heijnen, N. F. L., Raafs, A., van Kuijk, S. M. J., Smits, L. J. M., Janssen, E. B. N. J., Mulder, M. M. G., ... Florack, M. C. D. M. (2022). Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment. Scientific Reports, 12(1), Article 734. https://doi.org/10.1038/s41598-021-04531-x
    • Heijnen, N. F. L., Hagens, L. A., van Schooten, F.-J., Bos, L. D. J., van der Horst, I. C. C., Mommers, A., Schultz, M. J., Smit, M. R., Bergmans, D. C. J. J., Smolinska, A., & Schnabel, R. M. (2022). Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia. ERJ Open Research, 8(1), Article 00624-2021. https://doi.org/10.1183/23120541.00624-2021
    • Heuts, S., van der Horst, I. C. C., & Mingels, A. (2022). Towards an improved definition of periprocedural myocardial infarction: The role of high-sensitivity cardiac troponins. Journal of Cardiac Surgery, 37(1), 162-164. https://doi.org/10.1111/jocs.16107
  • 2021
    • Amer, A. Y. A., Wouters, F., Vranken, J., Dreesen, P., Boer, D. D., van Rosmalen, F., van Bussel, B. C. T., Smit-Fun, V., Duflot, P., Guiot, J., van der Horst, I. C. C., Mesotten, D., Vandervoort, P., Aerts, J. M., & Vanrumste, B. (2021). Vital Signs Prediction for COVID-19 Patients in ICU. Sensors, 21(23), Article 8131. https://doi.org/10.3390/s21238131
    • Cox, E. G. M., Onrust, M., Vos, M. E., Paans, W., Dieperink, W., Koeze, J., van der Horst, I. C. C., Wiersema, R., SICS Study Group, & SOCCS Student Team (2021). The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality. Critical Care, 25(1), Article 393. https://doi.org/10.1186/s13054-021-03809-w
    • Driessen, R. G. H., Groven, R. V. M., van Koll, J., Oudhuis, G. J., Posthouwer, D., van der Horst, I. C. C., Bergmans, D. C. J. J., & Schnabel, R. M. (2021). Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU. Infectious Diseases, 53(11), 830-838. https://doi.org/10.1080/23744235.2021.1942543
    • Strauch, U., Florack, M. C. D. M., Jansen, J., van Bussel, B. C. T., Beckers, S. K., Habers, J., Winkens, B., van der Horst, I. C. C., van Mook, W. N. K. A., & Bergmans, D. C. J. J. (2021). The QUality of Interhospital Transportation in the Euregion Meuse-Rhine (QUIT-EMR) score: a cross-validation study. BMJ Open, 11(11), Article e051100. https://doi.org/10.1136/bmjopen-2021-051100
    • Tas, J., Beqiri, E., van Kaam, R. C., Czosnyka, M., Donnelly, J., Haeren, R. H., van der Horst, I. C. C., Hutchinson, P. J., van Kuijk, S. M. J., Liberti, A. L., Menon, D. K., Hoedemaekers, C. W. E., Depreitere, B., Smielewski, P., Meyfroidt, G., Ercole, A., & Aries, M. J. H. (2021). Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial. Journal of Neurotrauma, 38(20), 2790-2800. https://doi.org/10.1089/neu.2021.0197
    • van Gassel, R. J. J., Bels, J., Remij, L., van Bussel, B. C. T., Posthuma, R., Gietema, H. A., Verbunt, J., van der Horst, I. C. C., Damink, S. W. M. O., van Santen, S., & van de Poll, M. C. G. (2021). Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study. Critical Care Medicine, 49(10), 1726-1738. https://doi.org/10.1097/CCM.0000000000005089
    • Boekel, M. F., Venema, C. S., Kaufmann, T., van der Horst, I. C. C., Vos, J. J., & Scheeren, T. W. L. (2021). The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study. Journal of Clinical Monitoring and Computing, 35(5), 1193-1202. https://doi.org/10.1007/s10877-020-00585-w
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