Werner Mess

Professor

Prof. Werner Mess received his medical degree in 1989 at the University of Düsseldorf, whereafter he was a resident in neurology in Mannheim/Heidelberg and Düsseldorf until 1994. As a certified neurologist he went to Nieuwegein (NL), where he worked as a clinical neurophysiologist for two years. In 1997, he became staff member and subsequently (2006) chairman of the Department of Clinical Neurophysiology at Maastricht University. In 2003, he received his PhD in Medicine at Maastricht University on the physical properties of microembolus detection and in 2007 became professor of clinical neurophysiology.

He has been involved in ultrasound since his first scientific activities resulting in a thesis based on CW Doppler measurements of the carotid and vertebral arteries in patients with an asymptomatic vascular disease. Since then, he has performed and participated in multiple studies on plaque morphology as well as microembolus detection. The latter led to his PhD degree and focussed on the physical aspects of the method. Currently, he focusses on long-term embolus detection, as well as the combined evaluation of functional, and anatomical properties of the carotid artery by means of ultrasound. He is an internationally recognised expert in this field and a member of the ESNCH and board member of the Neurosonology Research Group.

Department of Clinical Neurophysiology
P. Debyelaan 25, 6229 HX Maastricht
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 387 52 73

2024
- Kassem, M., Crombag, G. A. J. C., Stegers, J., Liem, M. I., Koornstra, E., Schreuder, F. H. B. M., van Dam-Nolen, D. H. K., Lucci, C., van der Geest, R. J., Daemen, M. J., van der Steen, A. F. W., Hendrikse, J., Mess, W. H., Bos, D., Wildberger, J. E., van Oostenbruggeb, R. J., Nederkoorn, P. J., & Kooi, M. E. (2024). Association between Antiplatelet Therapy and Changes in Intraplaque Hemorrhage in Patients with Mild to Moderate Symptomatic Carotid Stenosis: a longitudinal MRI study. Cerebrovascular Diseases, 53(5), 598-606. https://doi.org/10.1159/000535274
- Fandler-Höfler, S., Eppinger, S., Ambler, G., Nash, P., Kneihsl, M., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martínez-Domeño, A., Inamura, S., Yoshifuji, K., ... Microbleeds International Collaborative Network (2024). Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds. Jama network open, 7(10), Article e2439571. https://doi.org/10.1001/jamanetworkopen.2024.39571
- Nies, K. P. H., Aizaz, M., van Dam-Nolen, D. H. K., Goring, T. C. D., Schreuder, T. A. H. C. M. L., van Orshoven, N. P., Postma, A. A., Bos, D., Hendrikse, J., Nederkoorn, P., van der Geest, R., van Oostenbrugge, R. J., Mess, W. H., & Kooi, M. E. (2024). Signal intensity and volume of carotid intraplaque hemorrhage on magnetic resonance imaging and the risk of ipsilateral cerebrovascular events: the Plaque At RISK (PARISK) study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 26(2), Article 101049. https://doi.org/10.1016/j.jocmr.2024.101049
- Hodzelmans, J. J. A., Janssen, M. L. F., Reulen, J. P. H., Blijham, P. J., Koster, A., Stehouwer, C. D. A., Mess, W. H., & Sutedja, N. A. (2024). Reference values for nerve conduction studies of the peroneal, tibial, and sural nerve derived from a large population-based cohort: Associations with demographic and anthropometric characteristics-The Maastricht study. Muscle & nerve, 69(5), 588-596. https://doi.org/10.1002/mus.28076
- Prats-Sanchez, L., Camps-Renom, P., Nash, P. S., Wilson, D., Ambler, G., Best, J. G., Guasch-Jiménez, M., Ramos-Pachón, A., Martinez-Domeño, A., Lambea-Gil, Á., Díaz, G. E., Guisado-Alonso, D., Du, H., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y., Ay, H., Jung, S., Bornstein, N. M., ... Microbleeds International Collaborative Network (MICON) (2024). Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. Neurology, 102(7), Article e209173. https://doi.org/10.1212/WNL.0000000000209173
2023
- Kassem, M., Nies, K. P. H., Boswijk, E., van der Pol, J., Aizaz, M., Gijbels, M. J. J., Li, D., Bucerius, J., Mess, W. H., Wildberger, J. E., van Oostenbrugge, R. J., Moonen, R. P. M., Fan, Z., & Kooi, M. E. (2023). Quantification of carotid plaque composition with a multi-contrast atherosclerosis characterization (MATCH) MRI sequence. Frontiers in Cardiovascular Medicine, 10, Article 1227495. https://doi.org/10.3389/fcvm.2023.1227495
- Hazenberg, L., Aries, M. J. H., Beqiri, E., Mess, W. H., van Mook, W. N. K. A., Delnoij, T., Zeiler, F. A., van Kuijk, S., & Tas, J. (2023). Are NIRS-derived cerebral autoregulation and ABPopt values different between hemispheres in hypoxic-ischemic brain injury patients following cardiac arrest?Journal of Clinical Monitoring and Computing, 37(5), 1427–1430. https://doi.org/10.1007/s10877-023-01008-2
- Malik, A. E. F., Giudici, A., van der Laan, K. W. F., Op 't Roodt, J., Mess, W. H., Delhaas, T., Spronck, B., & Reesink, K. D. (2023). Detectable Bias between Vascular Ultrasound Echo-Tracking Systems: Relevance Depends on Application. Journal of Clinical Medicine, 12(1), Article 69. https://doi.org/10.3390/jcm12010069
2022
- van Dam-Nolen, D. H. K., Truijman, M. T. B., van der Kolk, A. G., Liem, M. I., Schreuder, F. H. B. M., Boersma, E., Daemen, M. J. A. P., Mess, W. H., van Oostenbrugge, R. J., van der Steen, A. F. W., Bos, D., Koudstaal, P. J., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Kooi, M. E., & PARISK Study Group (2022). Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA: The PARISK (Plaque At RISK) Study. JACC-Cardiovascular Imaging, 15(10), 1715-1726. https://doi.org/10.1016/j.jcmg.2022.04.003
- Lukas, A., Theunissen, M., de Korte-de Boer, D., van Kuijk, S., Van Noyen, L., Magerl, W., Mess, W., Buhre, W., & Peters, M. (2022). AMAZONE: prevention of persistent pain after breast cancer treatment by online cognitive behavioral therapy-study protocol of a randomized controlled multicenter trial. Trials, 23(1), Article 595. https://doi.org/10.1186/s13063-022-06549-6
- Sijben, L. C. J., Mess, W. H., Walter, U., Janssen, A. M. L., L Kuijf, M., Oosterloo, M., Weber, W. E. J., & Janssen, M. L. F. (2022). The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients. eNeurologicalSci, 27, Article 100400. https://doi.org/10.1016/j.ensci.2022.100400
- Crombag, G. A. J. C., Aizaz, M., Schreuder, F. H. B. M., Benali, F., Van Dam-Nolen, D. H. K., Liem, M. I. L., Lucci, C., van der Steen, A. F., Daemen, M. J. A. P., Mess, W. H., van der Lugt, A., Nederkoorn, P. J., Hendrikse, J., Hofman, P. A. M., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2022). Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage: The Plaque at Risk Study. American Journal of Neuroradiology, 43(2), 265-271. https://doi.org/10.3174/ajnr.A7384
2021
- Malik, A. E. F., Delhaas, T., Spronck, B., Henry, R. M. A., Joseph, J., Stehouwer, C. D. A., Mess, W. H., & Reesink, K. D. (2021). Single M-Line Is as Reliable as Multiple M-Line Ultrasound for Carotid Artery Screening. Frontiers in physiology, 12, Article 787083. https://doi.org/10.3389/fphys.2021.787083
- Weise, D., Groiss, S. J., Klinker, F., Mess, W. H., Milnik, V., & Zeller, D. (2021). Evozierte Potenziale – Reminder und Update. Klinische Neurophysiologie, 52(03), 195-211. https://doi.org/10.1055/a-1416-3874
- Stevens, R. R. F., Gommer, E. D., Aries, M. J. H., Ertl, M., Mess, W. H., Huberts, W., & Delhaas, T. (2021). Optic nerve sheath diameter assessment by neurosonology: A review of methodologic discrepancies. Journal of Neuroimaging, 31(5), 814-825. https://doi.org/10.1111/jon.12906
- Best, J. G., Ambler, G., Wilson, D., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Li, L. X., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sanchez, L., Martinez-Domeno, A., Inamura, S., Yoshifuji, K., Arsava, E. M., Horstmann, S., ... Werring, D. J. (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurology, 20(4), 294-303. https://doi.org/10.1016/S1474-4422(21)00024-7
- Florea, A., Kooi, M. E., Mess, W., Schurgers, L. J., Bucerius, J., & Mottaghy, F. M. (2021). Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[18F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design. Nutrients, 13(3), Article 994. https://doi.org/10.3390/nu13030994
- Maalmi, H., Wouters, K., Savelberg, H. H. C. M., van der Velde, J. H. P. M., Reulen, J. P. H., Mess, W., Schalkwijk, C. G., Stehouwer, C. D. A., Roden, M., Ziegler, D., Herder, C., & Schaper, N. C. (2021). Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study. BMJ Open Diabetes Research & Care, 9(1), Article 001698. https://doi.org/10.1136/bmjdrc-2020-001698
- Stevens, R. R. F., Huberts, W., Gommer, E. D., Ertl, M., Aries, M., Mess, W. H., & Delhaas, T. (2021). An Automated Algorithm for Optic Nerve Sheath Diameter Assessment from B-mode Ultrasound Images. Journal of Neuroimaging, 31(4), 724–732. https://doi.org/10.1111/jon.12851
2020
- van der Velde, J. H. P. M., Koster, A., Strotmeyer, E. S., Mess, W. H., Hilkman, D., Reulen, J. P. H., Stehouwer, C. D. A., Henry, R. M. A., Schram, M. T., van der Kallen, C. J. H., Schalkwijk, C. G., Savelberg, H. H. C. M., & Schaper, N. C. (2020). Cardiometabolic risk factors as determinants of peripheral nerve function: the Maastricht Study. Diabetologia, 63(8), 1648-1658. https://doi.org/10.1007/s00125-020-05194-5
- Gombert, A., Ruckbeil, M. V., Kotelis, D., Burger, S., Brugmayer, T., Mess, W. H., & Jacobs, M. J. (2020). Assessment of Neurone-Specific Enolase, Glial Fibrillary Acidic Protein and S100 B as Spinal Cord Ischemia Biomarkers in Patients Undergoing Open and Endovascular Complex Aortic Surgery: A Single-Center Experience. Annals of Vascular Surgery, 66, 424-433. https://doi.org/10.1016/j.avsg.2020.01.003
- Stevens, R. R. F., Donders, W. P., Quicken, S., van de Vosse, F. N., Mess, W. H., Delhaas, T., & Huberts, W. (2020). The Role of One-Dimensional Model-Generated Inter-Subject Variations in Systemic Properties on Wall Shear Stress Indices of Intracranial Aneurysms. Ieee Transactions on Biomedical Engineering, 67(4), 1030-1039. https://doi.org/10.1109/TBME.2019.2928416
- Oostveen, C. N., Weerwind, P. W., Bergs, P. P. E., Schmidli, J., Buhlmann, R., Schefold, J. C., Eberle, B., Consiglio, J., Schaelte, G., Kotelis, D., Hollands, A. W. H., Buhre, W. F. F. A., Schurink, G. W. H., Jacobs, M. J., van Mook, W. N. K. A., Mess, W. H., & Sutedja, N. A. (2020). Neurophysiological and paraspinal oximetry monitoring to detect spinal cord ischemia in patients during and after descending aortic repair: An international multicenter explorative study. Contemporary Clinical Trials Communications, 17, Article 100545. https://doi.org/10.1016/j.conctc.2020.100545
2019
- Crombag, G. A. J. C., van Hoof, R. H. M., Holtackers, R. J., Schreuder, F. H. B. M., Truijman, M. T. B., Schreuder, T. A. H. C. M. L., van Orshoven, N. P., Mess, W. H., Hofman, P. A. M., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2019). Symptomatic Carotid Plaques Demonstrate Less Leaky Plaque Microvasculature Compared With the Contralateral Side: A Dynamic Contrast-Enhanced Magnetic Resonance Imaging Study. Journal of the American Heart Association, 8(8), Article 011832. https://doi.org/10.1161/JAHA.118.011832
- Crombag, G. A. J. C., Schreuder, F. H. B. M., van Hoof, R. H. M., Truijman, M. T. B., Wijnen, N. J. A., Voo, S. A., Nelemans, P. J., Heeneman, S., Nederkoorn, P. J., Daemen, J.-W. H., Daemen, M. J. A. P., Mess, W. H., Wildberger, J. E., van Oostenbrugge, R. J., & Kooi, M. E. (2019). Microvasculature and intraplaque hemorrhage in atherosclerotic carotid lesions: a cardiovascular magnetic resonance imaging study. Journal of Cardiovascular Magnetic Resonance, 21(1), Article 15. https://doi.org/10.1186/s12968-019-0524-9
2018
- Hilkman, D. M. W., van Mook, W. N. K. A., Mess, W. H., & van Kranen-Mastenbroek, V. H. J. M. (2018). The Use of Continuous EEG Monitoring in Intensive Care Units in The Netherlands: A National Survey. Neurocritical Care, 29(2), 195-202. https://doi.org/10.1007/s12028-018-0525-9
- Crombag, G. A. J. C., Spronk, H. M., Nelemans, P., Schreuder, F. H. B. M., Truijman, M. T. B., van Dijk, A. C., de Rotte, A. A. J., Liem, M. I., Daemen, M. J. A. P., van der Steen, A. F. W., Mess, W. H., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Wildberger, J. E., ten Cate, H., van Oostenbrugge, R. J., & Kooi, M. E. (2018). No Association between Thrombin Generation and Intra-Plaque Haemorrhage in Symptomatic Carotid Atherosclerotic Plaques: The Plaque at RISK (PARISK) Study. Thrombosis and Haemostasis, 118(8), 1461-1469. https://doi.org/10.1055/s-0038-1666858
- Steinbuch, J., Schreuder, F. H. B. M., Reesink, K. D., Hoeks, A. P. G., & Mess, W. H. (2018). ORTHOGONAL B-MODE EVALUATION OF COMMON CAROTID ARTERY PLAQUES REVEALS THE ABSENCE OF OUTWARD REMODELING. Ultrasound in Medicine and Biology, 44(5), 986-994. https://doi.org/10.1016/j.ultrasmedbio.2017.12.013
- Leunissen, T., van Vriesland, D., den Ruijter, H., Moll, F., Mess, W., & de Borst, G. J. (2018). Validation of the Automated Electronic Microemboli Detection System in Patients Undergoing Carotid Endarterectomy. Ultraschall in der Medizin (Stuttgart, Germany : 1980), 39(2), 198-205. https://doi.org/10.1055/s-0043-106737
- Gombert, A., Grommes, J., Hilkman, D., Kotelis, D., Mess, W. H., & Jacobs, M. J. (2018). Recovery of lost motor evoked potentials in open thoracoabdominal aortic aneurysm repair using intercostal artery bypass. Journal of Vascular Surgery Cases and Innovative Techniques, 4(1), 54-57. https://doi.org/10.1016/j.jvscit.2017.12.004
2017
- Steinbuch, J., van Dijk, A. C., Schreuder, F. H. B. M., Truijman, M. T. B., de Rotte, A. A. J., Nederkoorn, P. J., van der Lugt, A., Hermeling, E., Hoeks, A. P. G., & Mess, W. H. (2017). High Spatial Inhomogeneity in the Intima-Media Thickness of the Common Carotid Artery is Associated with a Larger Degree of Stenosis in the Internal Carotid Artery: The PARISK Study. Ultraschall in der Medizin - European Journal of Ultrasound, 38(5), 523-529. https://doi.org/10.1055/s-0042-112220
- van Hoof, R. H. M., Voo, S. A., Sluimer, J. C., Wijnen, N. J. A., Hermeling, E., Schreuder, F. H. B. M., Truijman, M. T. B., Cleutjens, J. P. M., Daemen, M. J. A. P., Daemen, J.-W. H., van Oostenbrugge, R. J., Mess, W. H., Wildberger, J. E., Heeneman, S., & Kooi, M. E. (2017). Vessel Wall and Adventitial DCE-MRI Parameters Demonstrate Similar Correlations With Carotid Plaque Microvasculature on Histology. Journal of Magnetic Resonance Imaging, 46(4), 1053-1059. https://doi.org/10.1002/jmri.25648
- Steinbuch, J., van Dijk, A. C., Schreuder, F. H. B. M., Truijman, M. T. B., Hendrikse, J., Nederkoorn, P. J., van der Lugt, A., Hermeling, E., Hoeks, A. P. G., & Mess, W. H. (2017). Definition of common carotid wall thickness affects risk classification in relation to degree of internal carotid artery stenosis: the Plaque At RISK (PARISK) study. Cardiovascular Ultrasound, 15(1), Article 9. https://doi.org/10.1186/s12947-017-0097-4
- van Hoof, R. H. M., Schreuder, F. H. B. M., Nelemans, P., Truijman, M. T. B., van Orshoven, N. P., Schreuder, T. H., Mess, W. H., Heeneman, S., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2017). Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients. Cerebrovascular Diseases, 44(5-6), 297-303. https://doi.org/10.1159/000481146
2016
- Klooster, D. C. W., de Louw, A. J. A., Aldenkamp, A. P., Besseling, R. M. H., Mestrom, R. M. C., Carrette, S., Zinger, S., Bergmans, J. W. M., Mess, W. H., Vonck, K., Carrette, E., Breuer, L. E. M., Bernas, A., Tijhuis, A. G., & Boon, P. (2016). Technical aspects of neurostimulation: Focus on equipment, electric field modeling, and stimulation protocols. Neuroscience and Biobehavioral Reviews, 65, 113-141. https://doi.org/10.1016/j.neubiorev.2016.02.016
- Bouwmans, A. E. P., Weber, W. E. J., Leentjens, A. F. G., & Mess, W. H. (2016). Transcranial sonography findings related to depression in parkinsonian disorders: cross-sectional study in 126 patients. PEERJ, 4(5), Article e2037. https://doi.org/10.7717/peerj.2037
- Koppen, H., Palm-Meinders, I. H., Mess, W. H., Keunen, R. W., Terwindt, G. M., Launer, L. J., van Buchem, M. A., Kruit, M. C., & Ferrari, M. D. (2016). Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity. Neurology, 86(18), 1668-1675. https://doi.org/10.1212/WNL.0000000000002538
- Breuer, L. E. M., Boon, P., Bergmans, J. W. M., Mess, W. H., Besseling, R. M. H., de Louw, A., Tijhuis, A. G., Zinger, S., Bernas, A., Klooster, D. C. W., & Aldenkamp, A. P. (2016). Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?Neuroscience and Biobehavioral Reviews, 64, 1-11. https://doi.org/10.1016/j.neubiorev.2016.02.004
- Steinbuch, J., Hoeks, A. P. G., Hermeling, E., Truijman, M. T. B., Schreuder, F. H. B. M., & Mess, W. (2016). Standard B-Mode Ultrasound Measures Local Carotid Artery Characteristics as Reliably as Radiofrequency Phase Tracking in Symptomatic Carotid Artery Patients. Ultrasound in Medicine and Biology, 42(2), 586-595. https://doi.org/10.1016/j.ultrasmedbio.2015.07.030
- Bouwmans, A. E. P., Leentjens, A. F. G., Mess, W. H., & Weber, W. E. J. (2016). Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson's Disease, 2016, Article 4058580. https://doi.org/10.1155/2016/4058580
2015
- Severdija, E. E., Gommer, E. D., Weerwind, P. W., Reulen, J. P. H., Mess, W. H., & Maessen, J. G. (2015). Assessment of dynamic cerebral autoregulation and cerebral carbon dioxide reactivity during normothermic cardiopulmonary bypass. Medical & Biological Engineering & Computing, 53(3), 195-203. https://doi.org/10.1007/s11517-014-1225-z
2014
- Gommer, E. D., Bogaarts, G., Martens, E. G. H. J., Mess, W. H., & Reulen, J. P. H. (2014). Visually evoked blood flow responses and interaction with dynamic cerebral autoregulation: Correction for blood pressure variation. Medical Engineering & Physics, 36(5), 613-619. https://doi.org/10.1016/j.medengphy.2014.01.006
2013
- Goedee, H. S., Brekelmans, G. J. F., van Asseldonk, J. T. H., Beekman, R., Mess, W. H., & Visser, L. H. (2013). High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy - a review of the literature. European Journal of Neurology, 20(10), 1342-1351. https://doi.org/10.1111/ene.12182
- Schurink, G. W. H., De Haan, M. W., Peppelenbosch, A. G., Mess, W., & Jacobs, M. (2013). Spinal cord function monitoring during endovascular treatment of thoracoabdominal aneurysms: implications for staged procedures. Journal of Cardiovascular Surgery, 54(1), 117-124.
- Bouwmans, A. E. P., Vlaar, A. M. M., Mess, W. H., Kessels, A. G., & Weber, W. E. J. (2013). Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients. BMJ Open, 3(4), Article e002613. https://doi.org/10.1136/bmjopen-2013-002613
2012
- Greiner, A., Mess, W. H., Schmidli, J., Debus, E. S., Grommes, J., Dick, F., & Jacobs, M. J. (2012). Cyber medicine enables remote neuromonitoring during aortic surgery. Journal of Vascular Surgery, 55(5), 1227-1233. https://doi.org/10.1016/j.jvs.2011.11.121
- Gommer, E. D., Martens, E. G. H. J., Aalten, P., Shijaku, E., Verhey, F. R. J., Mess, W. H., Ramakers, I. H. G. B., & Reulen, J. P. H. (2012). Dynamic Cerebral Autoregulation in Subjects with Alzheimer's Disease, Mild Cognitive Impairment, and Controls: Evidence for Increased Peripheral Vascular Resistance with Possible Predictive Value. Journal of Alzheimer's Disease, 30(4), 805-813. https://doi.org/10.3233/JAD-2012-111628

Overview

Latest news & events

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

ZonMw grant on appropriate palliative care

10 December 2024

Werner Mess

Professor