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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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New CARIM initiative: Anna Maria van Schurman Stipend - call for proposals

New CARIM initiative: Anna Maria van Schurman Stipend - call for proposals

1 October 2024

In 2024, CARIM introduces the Anna Maria van Schurman Stipend, aimed at encouraging and supporting female researchers, named after the acknowledged ‘first female Dutch student’.

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Carim Maastricht
Carim Maastricht

Sébastien Foulquier

Assistant Professor

Sébastien Foulquier studied pharmaceutical sciences at the Faculty of Pharmacy of Nancy, France from 2002 until 2008 where he specialized in R&D. He joined the Cardiovascular division of the Servier Research Institute in Suresnes for his senior internship before graduating with a Pharm.D. thesis awarded as “Best experimental Pharm.D. thesis”. He pursued his studies with a Master in Cardiovascular physiopathology and pharmacology in Lyon, France and a PhD in Cardiovascular Pharmacology at Nancy University, France. During his PhD, he studied the impact of hypertension and the renin angiotensin system on the structure and function of the cerebral circulation in vivo. He completed his PhD in 3 years and got awarded with a prize for the best PhD thesis from the Faculty of Pharmacy. He joined Maastricht University in July 2012 as post-doctoral researcher.

Since 2012, Sebastien is leading research projects on cerebral small vessel disease, the most common form of Vascular Cognitive Impairment, with a focus on the contribution of vascular risk factors to Blood Brain Barrier dysfunction, microglial activation and cognitive dysfunction. He has obtained research grants from the European Society of Hypertension and Servier in 2015, from the Young Talent Program of the Dutch Heart Foundation-CVON 'Heart-Brain Connection' in 2016, from the European Foundation for the Study of Diabetes EFSD-Boehringer Ingelheim in 2018 together with Prof C. Schalkwijk and Prof R. van Oostenbrugge. He has participated in several EU projects and is currently involved as PI in the H2020-ITN-MINDSHIFT consortium and as WP leader in the H2020-CRUCIAL project. Since July 2018, he is affiliated at both Cardiovascular (CARIM) and Neuroscience (MHeNS) Institutes in Maastricht. Sebastien got promoted to Assistant Professor in 2020 and is now leading an experimental research group studying the vascular-glial interplay and its relevance for Cerebral Small Vessel Disease (cSVD). Beyond gaining more insights into cSVD pathobiology, he strives to identify key molecular and cellular targets to prevent and/or delay cSVD progression.

Sebastien-foulquier

Department of Pharmacology & Toxicology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G4.222
T: +31(0)43 388 14 09

  • 2025
    • Manukjan, N., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2025). Vascular endothelial growth factor: a double-edged sword in the development of white matter lesions. Neural Regeneration Research, 20(1), 191-192. https://doi.org/10.4103/NRR.NRR-D-23-01843
  • 2024
    • Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2024). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology. Advance online publication. https://doi.org/10.1007/s12035-024-04552-3
    • Manukjan, N., Chau, S., Caiment, F., van Herwijnen, M., Smeets, H. J., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2024). Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation. Molecular Neurobiology, 61(7), 4854-4867. https://doi.org/10.1007/s12035-023-03872-0
    • van der Laan, K. W. F., Reesink, K. D., Lambrichts, S., Bitsch, N. J. J. E., van der Taelen, L., Foulquier, S., Delhaas, T., Spronck, B., & Giudici, A. (2024). Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta. Journal of Biomechanics, 171, Article 112190. https://doi.org/10.1016/j.jbiomech.2024.112190
    • Berends, E., Pencheva, M. G., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2024). Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes. Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP286723
  • 2023
    • Nelissen, E., Schepers, M., Ponsaerts, L., Foulquier, S., Bronckaers, A., Vanmierlo, T., Sandner, P., & Prickaerts, J. (2023). Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?Pharmacological Research, 197(1), Article 106970. https://doi.org/10.1016/j.phrs.2023.106970
    • Berends, E., van Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2023). Methylglyoxal, a highly reactive dicarbonyl compound, as a threat for blood brain barrier integrity. Fluids and barriers of the CNS, 20(1), Article 75. https://doi.org/10.1186/s12987-023-00477-6
    • Giudici, A., van der Laan, K. W. F., van der Bruggen, M. M., Parikh, S., Berends, E., Foulquier, S., Delhaas, T., Reesink, K. D., & Spronck, B. (2023). Constituent-based quasi-linear viscoelasticity: a revised quasi-linear modelling framework to capture nonlinear viscoelasticity in arteries. Biomechanics and modeling in mechanobiology, 22(5), 1607–1623. https://doi.org/10.1007/s10237-023-01711-8
    • Manukjan, N., Majcher, D., Leenders, P., Caiment, F., van Herwijnen, M., Smeets, H. J. J., Suidgeest, E., van der Weerd, L., Vanmierlo, T., Jansen, J. F. A., Backes, W. H. H., van Oostenbrugge, R. J. J., Staals, J., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023). Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment. Acta neuropathologica communications, 11(1), Article 128. https://doi.org/10.1186/s40478-023-01627-5
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Colin, M., Delaitre, C., Foulquier, S., & Dupuis, F. (2023). The AT(1)/AT(2) Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System. Molecules, 28(14), Article 5481. https://doi.org/10.3390/molecules28145481
  • 2022
    • Kemps, H., Dessy, C., Dumas, L., Sonveaux, P., Alders, L., Van Broeckhoven, J., Font, L. P., Lambrichts, S., Foulquier, S., Hendrix, S., Brône, B., Lemmens, R., & Bronckaers, A. (2022). Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow. Journal of Cerebral Blood Flow and Metabolism, 42(6), 979-996. Article 0271678X221084410. https://doi.org/10.1177/0271678X221084410
  • 2021
    • Laukkanen, L., Diniz, C. R. A. F., Foulquier, S., Prickaerts, J., Castren, E., & Casarotto, P. C. (2021). Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21. Pharmaceuticals, 14(8), Article 773. https://doi.org/10.3390/ph14080773
  • 2020
    • Reinhold, S., Blankesteijn, W. M., & Foulquier, S. (2020). The Interplay of WNT and PPARγ Signaling in Vascular Calcification. Cells, 9(12), Article 2658. https://doi.org/10.3390/cells9122658
    • Kerkhofs, D., van Hagen, B. T., Milanova, I. V., Schell, K. J., van Essen, H., Wijnands, E., Goossens, P., Blankesteijn, W. M., Unger, T., Prickaerts, J., Biessen, E. A., van Oostenbrugge, R. J., & Foulquier, S. (2020). Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension. Theranostics, 10(21), 9512-9527. https://doi.org/10.7150/thno.44394
    • Manukjan, N., Ahmed, Z., Fulton, D., Blankesteijn, W. M., & Foulquier, S. (2020). A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease. Cells, 9(6), Article 1545. https://doi.org/10.3390/cells9061545
    • Foulquier, S. (2020). Brain perivascular macrophages: connecting inflammation to autonomic activity in hypertension. Hypertension Research, 43(2), 148-150. https://doi.org/10.1038/s41440-019-0359-7
  • 2019
    • Koizumi, T., Kerkhofs, D., Mizuno, T., Steinbusch, H. W. M., & Foulquier, S. (2019). Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia. Frontiers in Neuroscience, 13, Article 1291. https://doi.org/10.3389/fnins.2019.01291
    • Foulquier, S., Caolo, V., Swennen, G., Milanova, I., Reinhold, S., Recarti, C., Alenina, N., Bader, M., Steckelings, U. M., Vanmierlo, T., Post, M. J., Jones, E. A., van Oostenbrugge, R. J., & Unger, T. (2019). The role of receptor MAS in microglia-driven retinal vascular development. Angiogenesis, 22(4), 481-489. https://doi.org/10.1007/s10456-019-09671-3
    • Koizumi, T., Taguchi, K., Mizuta, I., Toba, H., Ohigashi, M., Onishi, O., Ikoma, K., Miyata, S., Nakata, T., Tanaka, M., Foulquier, S., Steinbusch, H. W. M., & Mizuno, T. (2019). Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model. Journal of Neuroinflammation, 16(1), Article 79. https://doi.org/10.1186/s12974-019-1467-7
  • 2018
    • Meyer, M., Foulquier, S., Dupuis, F., Flament, S., Grimaud, L., Henrion, D., Lartaud, I., Monard, G., Grillier-Vuissoz, I., & Boisbrun, M. (2018). Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor. European Journal of Medicinal Chemistry, 158, 334-352. https://doi.org/10.1016/j.ejmech.2018.08.082
    • Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J., & Unger, T. (2018). Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice. Hypertension Research, 41(10), 817-827. https://doi.org/10.1038/s41440-018-0090-9
    • Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2018). WNT Signaling in Cardiac and Vascular Disease. Pharmacological Reviews, 70(1), 68-141. https://doi.org/10.1124/pr.117.013896
  • 2016
    • Paulis, L., Foulquier, S., Namsolleck, P., Recarti, C., Steckelings, U. M., & Unger, T. (2016). Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders. Drugs, 76(1), 1-12. https://doi.org/10.1007/s40265-015-0509-4
  • 2014
    • Foulquier, S., Boehm, M., Schmieder, R., Sleight, P., Teo, K., Yusuf, S., Schumacher, H., & Unger, T. (2014). Impact of telmisartan on cardiovascular outcome in hypertensive patients at high risk: a Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease subanalysis. Journal of Hypertension, 32(6), 1334-1341. https://doi.org/10.1097/HJH.0000000000000154
    • Namsolleck, P., Recarti, C., Foulquier, S., Steckelings, U. M., & Unger, T. (2014). AT(2) Receptor and Tissue Injury: Therapeutic Implications. Current Hypertension Reports, 16(2), Article 416. https://doi.org/10.1007/s11906-013-0416-6
  • 2012
    • Foulquier, S., Steckelings, U. M., & Unger, T. (2012). Impact of the AT(2) Receptor Agonist C21 on Blood Pressure and Beyond. Current Hypertension Reports, 14(5), 403-409. https://doi.org/10.1007/s11906-012-0291-6
Overview