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ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

ZonMw grant Middellange termijn effecten van COVID-19 maatregelen

20 August 2024

The project 'Impact of COVID-19 protective measures and shielding in vulnerable patients with kidney failure', coordinated by Prof. Marc Hemmelder and Drs Pim Bouwmans (Dept of Internal Medicine), has been granted by ZonMw. 

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Professorship Henri Spronk

Professorship Henri Spronk

12 August 2024

Dr Henri Spronk (Dept of Biochemistry) has been appointed as professor of ‘Biochemistry of Atherothrombosis’ as of 1 May 2024.

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Carim Maastricht
Carim Maastricht

Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Iwanvdhorst1

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2024
    • van de Koolwijk, A. F., Delnoij, T. S. R., Suverein, M. M., Essers, B. A. B., Hermanides, R. C., Otterspoor, L. C., Elzo Kraemer, C. V., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C. A., Dos Reis Miranda, D., Akin, S., de Metz, J., van der Horst, I. C. C., Winkens, B., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial. Resuscitation Plus, 19, Article 100669. https://doi.org/10.1016/j.resplu.2024.100669
    • Heines, S. J. H., de Jongh, S. A. M., de Jongh, F. H. C., Segers, R. P. J., Gilissen, K. M. H., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2024). A novel positive end-expiratory pressure titration using electrical impedance tomography in spontaneously breathing acute respiratory distress syndrome patients on mechanical ventilation: an observational study from the MaastrICCht cohort. Journal of Clinical Monitoring and Computing. Advance online publication. https://doi.org/10.1007/s10877-024-01212-8
    • Heuts, S., Bova, R., Romeo, J. L. R., Vriesendorp, P. A., Van Der Horst, I. C. C., Segers, P., Maessen, J. G., Gollman-Tepeköylü, C., Van 't Hof, A. W. J., Bidar, E., & Lux, A. (2024). The prognostic impact of unplanned invasive coronary angiography following coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery, 66(2), Article ezae304. https://doi.org/10.1093/ejcts/ezae304
    • Mencke, R., Al Ali, L., de Koning, M.-S. L. Y., Pasch, A., Minnion, M., Feelisch, M., van Veldhuisen, D. J., van der Horst, I. C. C., Gansevoort, R. T., Bakker, S. J. L., de Borst, M. H., van Goor, H., van der Harst, P., Lipsic, E., & Hillebrands, J.-L. (2024). Serum Calcification Propensity Is Increased in Myocardial Infarction and Hints at a Pathophysiological Role Independent of Classical Cardiovascular Risk Factors. Arteriosclerosis Thrombosis and Vascular Biology, 44(8), 1884-1894. https://doi.org/10.1161/ATVBAHA.124.320974
    • de Kok, J. W. T. M., van Bussel, B. C. T., Schnabel, R., van Herpt, T. T. W., Driessen, R. G. H., Meijs, D. A. M., Goossens, J. A., Mertens, H. J. M. M., van Kuijk, S. M. J., Wynants, L., van der Horst, I. C. C., & van Rosmalen, F. (2024). Corrigendum to Table 0; documenting the steps to go from clinical database to research dataset Journal of Clinical Epidemiology Volume 170 (2024) 111342. Journal of Clinical Epidemiology, 172, Article 111436. https://doi.org/10.1016/j.jclinepi.2024.111436
    • Heuts, S., Ubben, J. F. H., Kawczynski, M. J., Gabrio, A., Suverein, M. M., Delnoij, T. S. R., Kavalkova, P., Rob, D., Komárek, A., van der Horst, I. C. C., Maessen, J. G., Yannopoulos, D., Belohlávek, J., Lorusso, R., & van de Poll, M. C. G. (2024). Extracorporeal cardiopulmonary resuscitation versus standard treatment for refractory out-of-hospital cardiac arrest: a Bayesian meta-analysis. Critical Care, 28(1), Article 217. https://doi.org/10.1186/s13054-024-05008-9
    • Delnoij, T. S. R., Suverein, M. M., Essers, B. A. B., Hermanides, R. C., Otterspoor, L., Elzo Kraemer, C. V., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C., Akin, S., de Metz, J., van der Horst, I. C. C., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Cost-effectiveness of extracorporeal cardiopulmonary resuscitation vs. conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: A pre-planned, trial-based economic evaluation. European Heart Journal: Acute Cardiovascular Care, 13(6), 484-492. https://doi.org/10.1093/ehjacc/zuae050
    • Ubben, J. F. H., Heuts, S., Delnoij, T. S. R., Suverein, M. M., Hermanides, R. C., Otterspoor, L. C., Kraemer, C. V. E., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C., Dos Reis Miranda, D., Akin, S., de Metz, J., van der Horst, I. C. C., Winkens, B., Maessen, J. G., Lorusso, R., & van de Poll, M. C. G. (2024). Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial. Resuscitation Plus, 18, Article 100657. https://doi.org/10.1016/j.resplu.2024.100657
    • van der Knaap, N., de Vreeze, F., van Rosmalen, F., Wintjens, M. S. J. N., van Santen, S., Linden, D. E. J., Staals, J., van Mook, W. N. K. A., Jansen, J. F. A., van der Horst, I. C. C., van Bussel, B. C. T., & Ariës, M. J. H. (2024). The incidence of neurological complications in mechanically ventilated COVID-19 ICU patients: An observational single-center cohort study in three COVID-19 periods. Clinical Neurology and Neurosurgery, 241, Article 108311. https://doi.org/10.1016/j.clineuro.2024.108311
    • de Kok, J. W. T. M., van Bussel, B. C. T., Schnabel, R., van Herpt, T. T. W., Driessen, R. G. H., Meijs, D. A. M., Goossens, J. A., Mertens, H. J. M. M., van Kuijk, S. M. J., Wynants, L., van der Horst, I. C. C., & van Rosmalen, F. (2024). Table 0; documenting the steps to go from clinical database to research dataset. Journal of Clinical Epidemiology, 170, Article 111342. https://doi.org/10.1016/j.jclinepi.2024.111342
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